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Supramolecular Polymers Based on Cyclodextrins for Drug and Gene Delivery

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Biofunctionalization of Polymers and their Applications

Part of the book series: Advances in Biochemical Engineering / Biotechnology ((ABE,volume 125))

Abstract

Supramolecular polymers based on cyclodextrins (CDs) have inspired interesting and rapid developments as novel biomaterials in a broad range of drug and gene delivery applications, due to their low cytotoxicity, controllable size, and unique architecture. This review will summarize the potential applications of polyrotaxanes in the field of drug delivery and gene delivery. Generally, cyclodextrin-based biodegradable polypseudorotaxane hydrogels could be used as a promising injectable drug delivery system for sustained and controlled drug release. Temperature-responsive, pH-sensitive, and controllable hydrolyzable polyrotaxane hydrogels have attracted much attention because of their controllable properties, and the self-assembly micelles formed by amphiphilic copolymer threaded with CDs could be used as a carrier for controlled and sustained drug release. Polyrotaxanes with drug or ligand conjugated CDs threaded on a polymer chain with a biodegradable end group could be useful for controlled and multivalent targeted delivery. In the field of gene delivery, cationic polyrotaxanes consisting of multiple OEI-grafted CDs threaded on a block copolymer chain are attractive non-viral gene carries due to the strong DNA-binding ability, low cytotoxicity, and high gene delivery capability. Furthermore, cytocleavable end-caps were introduced in the polyrotaxane systems in order to ensure efficient endosomal escape for intracellular trafficking of DNA. The development of the supramolecular approach using CD-containing polyrotaxanes is expected to provide a new paradigm for biomaterials.

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Abbreviations

CD:

Cyclodextrin

PEI:

Polyethylenimine

OEI:

Oligoethylenimine

PEG or PEO:

Poly (ethylene glycol) or poly (ethylene oxide)

P (EO-r-PO):

Poly [(ethylene oxide)-ran-(propylene oxide)]

PEO–PHB–PEO:

PEO–poly [(R)-3-hydroxybutyrate]–PEO

PCL–PTHF–PCL:

Poly (ε-caprolactone)–poly(tetrahydrofuran)–poly(ε-caprolactone)

PNIPAAm:

Poly (N-isopropylacrylamide)

PEO–PCL:

Poly (ethylene oxide)-b-poly (ε-caprolactone)

PEG-PDMAEMA:

Poly (ethylene oxide)-block poly ((dimethylamino ethylmethacrylate)

PAMAM:

Polyamidoamine

l-Phe:

l-phenylalanine

CEE:

Carboxyethylester

DMAB:

4-(N,N-dimethylamino) benzoyl

hPEPT1:

Human peptide transporter

H–l-PheGlyGly:

l-phenylalanlycylglycine

MA:

Methacrylate

LMWP:

Low molecular weight protamine

LCST:

Lower critical solution temperatures

BAEE:

N-α-benzoyl-arginine ethylesterv

AEC:

Aminoethylcarbamoyl

DMAE:

Dimethylaminoethyl

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Authors and Affiliations

  1. Division of Bioengineering, Faculty of Engineering, National University of Singapore (NUS), 7 Engineering Drive 1, Singapore, 117574, Singapore

    Jia Jing Li, Feng Zhao & Jun Li

  2. A*STAR (Agency for Science, Technology and Research), Institute of Materials Research and Engineering, 3 Research Link, Singapore, 117602, Singapore

    Jun Li

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  1. Jia Jing Li
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  2. Feng Zhao
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Correspondence to Jun Li .

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Editors and Affiliations

  1. Technical University Graz, Institut für Umweltbiotechnologie, Petersgasse 12/I, Graz, 8010, Austria

    Gibson Stephen Nyanhongo

  2. Technical University Graz, Institut für Biotechnologie und Bioproze, Petersgasse 12/I, Graz, 8010, Austria

    Walter Steiner

  3. Technical University Graz, Institut für Umweltbiotechnologie, Petersgasse 12/I, Graz, 8010, Austria

    Georg Gübitz

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Li, J.J., Zhao, F., Li, J. (2010). Supramolecular Polymers Based on Cyclodextrins for Drug and Gene Delivery. In: Nyanhongo, G., Steiner, W., Gübitz, G. (eds) Biofunctionalization of Polymers and their Applications. Advances in Biochemical Engineering / Biotechnology, vol 125. Springer, Berlin, Heidelberg. https://doi.org/10.1007/10_2010_91

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