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Bioreactors in Tissue Engineering: Scientific Challenges and Clinical Perspectives

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Bioreactor Systems for Tissue Engineering

Part of the book series: Advances in Biochemical Engineering/Biotechnology ((ABE,volume 112))

In this Chapter we discuss the role of bioreactors in the translational paradigm of Tissue Engineering approaches from basic research to streamlined tissue manufacturing. In particular, we will highlight their functions as: (1) Pragmatic tools for tissue engineers, making up for limitations of conventional manual and static techniques, enabling automation and allowing physical conditioning of the developing tissues; (2) 3D culture model systems, enabling us to recapitulate specific aspects of the actual in vivo milieu and, when properly integrated with computational modeling efforts and sensing and control techniques, to address challenging scientific questions; (3) Tissue manufacturing devices, implementing bioprocesses so as to support safe, standardized, scaleable, traceable and possibly cost-effective production of grafts for clinical use. We will provide evidences that fundamental knowledge gained through the use of well-defined and controlled bio-reactor systems at the research level will be essential to define, optimize, and moreover, streamline the key processes required for efficient manufacturing models.

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Authors and Affiliations

  1. Institute for Surgical Research and Hospital Management, University Hospital Basel, Hebelstrasse 20, Basel, 4031, Switzerland

    D. Wendt, S. A. Riboldi & I. Martin

  2. Department of Structural Engineering, Politecnico di Milano, Laboratory of Biological Structure Mechanics, Piazza Leonardo Da Vinci 32, Milano, 20133, Italy

    M. Cioffi

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  1. D. Wendt
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  2. S. A. Riboldi
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  3. M. Cioffi
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  4. I. Martin
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Editor information

Editors and Affiliations

  1. Institute of Technical Chemistry, University of Hannover, Callinstraβe 3, Hannover, 30167, Germany

    Cornelia Kasper

  2. Ludwig Boltzmann Institut für, Klinische und Experimentelle, Traumatologie Donaueschingenstr. 13, Wien, 1200, Austria

    Martijn van Griensven

  3. TU Hamburg-Harburg, Institut für Biotechnologie und Verfahrenstechnik Denickestr. 15, Hamburg, 21073, Germany

    Ralf Pörtner

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Wendt, D., Riboldi, S.A., Cioffi, M., Martin, I. (2009). Bioreactors in Tissue Engineering: Scientific Challenges and Clinical Perspectives. In: Kasper, C., van Griensven, M., Pörtner, R. (eds) Bioreactor Systems for Tissue Engineering. Advances in Biochemical Engineering/Biotechnology, vol 112. Springer, Berlin, Heidelberg. https://doi.org/10.1007/10_2008_1

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