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References

  1. Gharib H. Changing concepts in the diagnosis and management of thyroid nodules. Endocrinol Metab Clin North Am 1997; 26:777–800.

    Article  PubMed  CAS  Google Scholar 

  2. Weiss RE, Lado-Abeal J. Thyroid nodules: diagnosis and therapy. Cur Opin Oncol 2002; 14:46–52.

    Article  Google Scholar 

  3. Castro MR, Caraballo PJ, Morris JC. Effectiveness of thyroid hormone suppressive therapy in benign solitary thyroid nodules: a meta-analysis. J Clin Endocrinol Metab 2002; 87:4154–4159.

    Article  PubMed  CAS  Google Scholar 

  4. Lawrence W Jr, Kaplan BJ. Diagnosis and management of patients with thyroid nodules. J Surg Oncol 2002; 80(Suppl):157–170.

    Article  PubMed  Google Scholar 

  5. Vander JB, Gaston EA, Dawber TR. The significance of nontoxic thyroid nodules: Final report of a 15-year study of the incidence of thyroid malignancy. Ann Intern Med 1968; 69:537–540.

    PubMed  CAS  Google Scholar 

  6. Mazzaferri EL. Management of a solitary thyroid nodule. N Engl J Med 1993; 328:553–559.

    Article  PubMed  CAS  Google Scholar 

  7. Tunbridge WM, Evered DC, Hall R, et al. The spectrum of thyroid disease in a community: the Whickham survey. Clin Endocrinol 1977; 7:481–493.

    CAS  Google Scholar 

  8. Aghini-Lombardi F, Antonangeli L, Martino E, et al. The spectrum of thyroid disorders in an iodine-deficient community: the Pescopanano Survey. J Clin Endocrinol Metab 1999; 84:561–566.

    Article  PubMed  CAS  Google Scholar 

  9. Horlocker TT, Hay JE, James EM, Reading CC, Charboneau JW. Prevalence of incidental nodular thyroid disease detected during high resolution parathyroid ultrasonography. In: Medeiros-Neto G, Gaitan E (eds) Frontiers in thyroidology, Vol 2. New York: Plenum Medical, 1985:1309–1312.

    Google Scholar 

  10. Stark DD, Clark OH, Gooding GA, Moss AA. High resolution ultrasonography and computed tomography of thyroid lesions in patients with hyperparathyroidism. Surgery 1983; 94:863–868.

    PubMed  CAS  Google Scholar 

  11. Ezzat S, Sarti DA, Cain DR, Braunstein GD. Thyroid incidentalomas. Prevalence by palpation and ultrasonography. Arch Intern Med 1994; 154:1834–1840.

    Article  Google Scholar 

  12. Mortensen JD, Woolner LB, Bennett WA. Gross and microscopic findings in clinically normal thyroid glands. J Clin Endocrinol Metab 1955; 15:1270–1280.

    Article  PubMed  CAS  Google Scholar 

  13. Walsh RM, Watkinson JC, Franklyn J. The management of the solitary thyroid nodule: a review. Clin Otolaryngol 1999; 24:388–397.

    Article  PubMed  CAS  Google Scholar 

  14. Rojeski MT, Gharib H. Nodular thyroid disease. Evaluation and management. N Engl J Med 1985; 313:428–436.

    Article  PubMed  CAS  Google Scholar 

  15. Franklyn JA, Daykin J, Young J, Oates GD, Sheppard MC. Fine needle aspiration cytology in diffuse or multinodular goitre compared to solitary thyroid nodules. BMJ 1993; 307:240.

    PubMed  CAS  Google Scholar 

  16. Tollin SR, Mery GM, Jelveh N, et al. The use of fine-needle aspiration biopsy under ultrasound guidance to assess the risk of malignancy in patients with a multinodular goiter. Thyroid 2000; 10:235–241.

    PubMed  CAS  Google Scholar 

  17. Burch HB. Evaluation and management of the solid thyroid nodule. Endocrinol Metab Clin North Am 1995; 24:663–710.

    PubMed  CAS  Google Scholar 

  18. Gharib H, Mazzaferri EL. Thyroxine suppressive therapy in patients with nodular thyroid disease. Ann Intern Med 1998; 128:386–394.

    PubMed  CAS  Google Scholar 

  19. Boey J, Hsu C, Collins RJ. False-negative errors in fine-needle aspiration biopsy of dominant nodules: a prospective follow-up study. World J Surg 1986; 10:623–630.

    Article  PubMed  CAS  Google Scholar 

  20. Kuma K, Matsuzuka F, Kobayashi A, et al. Outcome of long standing solitary thyroid nodules. World J Surg 1992; 16:583–587.

    Article  PubMed  CAS  Google Scholar 

  21. Alexander EK, Hurwitz S, Heering JP, et al. Natural history of benign solid and cystic thyroid nodules. Ann Intern Med 2003; 138:315–318.

    PubMed  Google Scholar 

  22. Derwahl M, Studer H. Nodular goiter and goiter nodules: Where iodine deficiency falls short of explaining the facts. Exp Clin Endocrinol Diabetes 2001; 109: 250–260.

    Article  PubMed  CAS  Google Scholar 

  23. Weetman AP, McGregor AM. Autoimmune thyroid disease: further developments in our understanding. Endocr Rev 1994; 15:788–830.

    Article  PubMed  CAS  Google Scholar 

  24. Paleri V, Maroju RS, Ali MS, Ruckley RW. Spontaneous retro-and parapharyngeal haematoma caused by intrathyroid bleed. J Laryngol Otol 2002; 116:854–858.

    Article  PubMed  Google Scholar 

  25. Salabe GB. Pathogenesis of thyroid nodules: histological classification? Biomed Pharmacother 2001; 55:39–53.

    Article  PubMed  CAS  Google Scholar 

  26. Moretti F, Nanni S, Pontecorvi A. Molecular pathogenesis of thyroid nodules and cancer. Baillière’s Clin Endocrinol Metab 2000; 14:517–539.

    CAS  Google Scholar 

  27. Dremier S, Coppee F, Delange F, Vassart G, Dumont JE, Van Sande J. Thyroid autonomy. Mechanism and clinical effects. J Clin Endocrinol Metab 1996; 81:4187–4193.

    Article  PubMed  CAS  Google Scholar 

  28. Kimura ET, Nikiforova MN, Zhu Z, Knauf JA, Nikiforov YE, Fagin JA. High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signalling pathway in papillary thyroid carcinoma. Cancer Res 2003; 63:1454–1457.

    PubMed  CAS  Google Scholar 

  29. Fagin JA. Branded from the start — distinct oncogenic initiating events may determine tumor fate in the thyroid. Mol Endocrinol 2002; 16:903–911.

    Article  PubMed  CAS  Google Scholar 

  30. Schneider AB. Radiation-induced thyroid tumors. Endocrinol Metab Clin North Am 1990; 19:495–508.

    PubMed  CAS  Google Scholar 

  31. Ortiz R, Hupart KH, DeFesi CR, Surks MI. Effect of early referral to an endocrinologist on efficiency and cost of evaluation and development of treatment plan in patients with thyroid nodules. J Clin Endocrinol Metab 1998; 83:3803–3807.

    Article  PubMed  CAS  Google Scholar 

  32. Raber W, Kaserer K, Niederle B, Vierhapper H. Risk factors for malignancy of thyroid nodules initially identified as follicular neoplasia by fine-needle aspiration: results of a prospective study of one hundred and twenty patients. Thyroid 2000; 10:709–712.

    Article  PubMed  CAS  Google Scholar 

  33. Hahm JR, Lee MS, Min YK, et al. Routine measurement of serum calcitonin is useful for early detection of medullary thyroid carcinoma in patients with nodular thyroid diseases. Thyroid 2001; 11:73–80.

    Article  PubMed  CAS  Google Scholar 

  34. Elisei R, Bottici V, Luchetti F, et al. Impact of routine measurement of serum calcitonin on the diagnosis and outcome of medullary thyroid cancer: experience in 10,864 patients with nodular thyroid disorders. J Clin Endocrinol Metab 2004; 89:163–168.

    Article  PubMed  CAS  Google Scholar 

  35. Belfiore A, La Rosa GL. Fine-needle aspiration biopsy of the thyroid. Endocrinol Metab Clin North Am 2001; 30:361–400.

    Article  PubMed  CAS  Google Scholar 

  36. Caplan RH, Wester SM, Lambert PJ, Rooney BL. Efficient evaluation of thyroid nodules by primary care providers and thyroid specialists. Am J Managed Care 2000; 6:1134–1140.

    CAS  Google Scholar 

  37. Burch HB, Burman KD, Reed HL, Buckner L, Raber T, Ownbey JL. Fine needle aspiration of thyroid nodules. Determinants of insufficiency rate and malignancy yield at thyroidectomy. Acta Cytol 1996; 40:1176–1183.

    PubMed  CAS  Google Scholar 

  38. Morgan JL, Serpell JW, Cheng MSP. Fine-needle aspiration cytology of thyroid nodules: how useful is it? Aust N Z J Surg 2003; 73:480–483.

    Article  Google Scholar 

  39. Tabaqchali MA, Hanson JM, Johnson SJ, Wadehra V, Lennard TW, Proud G. Thyroid aspiration cytology in Newcastle: a six year cytology/histology correlation study. Ann R Coll Surg Eng 2000; 82:149–155.

    CAS  Google Scholar 

  40. Sclabas GM, Staerkel GA, Shapiro SE, et al. Fine-needle aspiration of the thyroid and correlation with histopathology in a contemporary series of 240 patients. Am J Surg 2003; 186:702–709.

    Article  PubMed  Google Scholar 

  41. Poller DN, Ibrahim AK, Cummings MH, Mikel JJ, Boote D, Perry M. Fine-needle aspiration of the thyroid. Cancer 2000; 90:239–244.

    Article  PubMed  CAS  Google Scholar 

  42. Chow LS, Gharib H, Goellner JR, van Heerden JA. Nondiagnostic thyroid fine-needle aspiration cytology: management dilemmas. Thyroid 2001; 11:1147.

    Article  PubMed  CAS  Google Scholar 

  43. Karstrup S, Balslev E, Juul N, Eskildsen PC, Baumbach L. US-guided fine needle aspiration versus coarse needle biopsy of thyroid nodules. Eur J Ultrasound 2001; 13:1–5.

    Article  PubMed  CAS  Google Scholar 

  44. Hatada T, Okada K, Ishii H, Ichii S, Utsunomiya J. Evaluation of ultrasound-guided fine-needle aspiration biopsy for thyroid nodules. Am J Surg 1998; 175:133–136.

    Article  PubMed  CAS  Google Scholar 

  45. Danese D, Sciacchitano S, Farsetti A, Andreoli M, Pontecorvi A. Diagnostic accuracy of conventional versus sonography-guided fine-needle aspiration biopsy of thyroid nodules. Thyroid 1998; 8:15–21.

    PubMed  CAS  Google Scholar 

  46. Kim EK, Park CS, Chung WY, et al. New sonographic criteria for recommending fine-needle aspiration biopsy of nonpalpable solid nodules of the thyroid. Am J Roentgenol 2002; 178:687–691.

    Google Scholar 

  47. Hedayati N, McHenry CR. The clinical significance of an isofunctioning thyroid nodule. Am Surg 2003; 69:311–315.

    PubMed  Google Scholar 

  48. Burch HB, Shakir F, Fitzsimmons TR, Jaques DP, Shriver CD. Diagnosis and management of the autonomously functioning thyroid nodule: the Walter Reed Army Medical Center experience, 1975–1996. Thyroid 1998; 8:871–880.

    PubMed  CAS  Google Scholar 

  49. Monzani F, Caraccio N, Goletti O, et al. Five-year follow-up of percutaneous ethanol injection for the treatment of hyperfunctioning thyroid nodules: a study of 117 patients. Clin Endocrinol 1997; 46:9–15.

    Article  CAS  Google Scholar 

  50. Del Prete S, Caraglia M, Russo D, et al. Percutaneous ethanol injection efficacy in the treatment of large symptomatic thyroid cystic nodules: ten-year follow-up of a large series. Thyroid 2002; 12:815–821.

    Article  PubMed  Google Scholar 

  51. Manders JM, Corstens FH. Radioiodine therapy of euthyroid multinodular goitres. Eur J Nucl Med Mol Imaging 2002; 29(Suppl 2):S466–470.

    Article  PubMed  CAS  Google Scholar 

  52. Bahar G, Braslavsky D, Shpitzer T, et al. The cytological and clinical value of the thyroid “follicular lesion”. Am J Otolaryngol 2003; 24:217–220.

    Article  PubMed  Google Scholar 

  53. Monzani F, Caraccio N, Iacconi P, et al. Prevalence of cancer in follicular thyroid nodules: is there still a role for intraoperative frozen section analysis? Thyroid 2003; 13:389–394.

    Article  PubMed  Google Scholar 

  54. Nabriski D, Ness-Abramof R, Brosh TO, Konen O, Shapiro MS, Shenkman L. Clinical relevance of nonpalpable thyroid nodules as assessed by ultrasound-guided fine needle aspiration biopsy. J Endocrinol Invest 2003; 26:61–64.

    PubMed  CAS  Google Scholar 

  55. Papini E, Guglielmi R, Bianchini A, et al. Risk of malignancy in nonpalpable thyroid nodules: predictive value of ultrasound and color-Doppler features. J Clin Endocrinol Metab 2002; 87:1941–1946.

    Article  PubMed  CAS  Google Scholar 

  56. Nam-Goong IS, Kim H, Gong G, et al. Ultrasonography-guided fine-needle aspiration of thyroid incidentaloma: correlation with pathological findings. Clinical endocrinology. Clin Endocrinol 2004; 60:21–28.

    Article  Google Scholar 

  57. AACE clinical practice guidelines for the diagnosis and management of thyroid nodules. http://www.aace.com/clin/guidelines/thyroid_nodules.pdf.

    Google Scholar 

  58. Hagag P, Strauss S, Weiss M. Role of ultrasound-guided fine-needle aspiration biopsy in evaluation of nonpalpable thyroid nodules. Thyroid 1998; 8:989–995.

    Article  PubMed  CAS  Google Scholar 

  59. Blum M. Why do clinicians continue to debate the use of levothyroxine in the diagnosis and management of thyroid nodules? Ann Intern Med 1995; 122:63–64.

    PubMed  CAS  Google Scholar 

  60. Bartolazzi A, Gasbarri A, Papotti M, et al. Application of an immunodiagnostic method for improving preoperative diagnosis of nodular thyroid lesions. Lancet 2001; 357:1644–1650.

    Article  PubMed  CAS  Google Scholar 

  61. Haugen BR, Woodmansee WW, McDermott MT. Towards improving the utility of fine-needle aspiration biopsy for the diagnosis of thyroid tumours. Clin Endocrinol 2002; 56:281–290.

    Article  CAS  Google Scholar 

  62. Hegedus L.Clinical practice. The thyroid nodule. N Engl J Med 2004; 351:1764–1771.

    Google Scholar 

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Perros, P. (2006). Thyroid Nodules. In: Mazzaferri, E.L., Harmer, C., Mallick, U.K., Kendall-Taylor, P. (eds) Practical Management of Thyroid Cancer. Springer, London. https://doi.org/10.1007/1-84628-013-3_7

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