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Cerebral Disease Other than Stroke and Transient Ischemic Attack in Antiphospholipid Syndrome

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Hughes Syndrome

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References

  1. Hughes GRV. Thrombosis, abortion, cerebral disease and the lupus anticoagulant. BMJ 1983;287:1088–1089.

    Article  PubMed  CAS  Google Scholar 

  2. Harris EN, Englert H, Derue G, Hughes GRV, Gharavi A. Antiphospholipid antibodies in acute Guillain-Barré syndrome. Lancet 1983;ii:1361–1362.

    Article  Google Scholar 

  3. Hughes GRV. The Prosser-White oration 1983. Connective tissue disease and the skin. Clin Exp Dermatol 1984;9:535–544.

    Article  PubMed  CAS  Google Scholar 

  4. Harris EN, Gharavi AE, Mackworth-Young CG, Patel BM, Derue G, Hughes GRV. Lupoid sclerosis: a possible pathogenetic role for antiphospholipid antibodies. Ann Rheum Dis 1985;44:281–283.

    PubMed  CAS  Google Scholar 

  5. Asherson R, Mercey D, Phillips G, et al. Recurrent stroke and multi-infarct dementia in systemic lupus erythematosus: association with antiphospholipid antibodies. Ann Rheum Dis 1987;46:605–611.

    PubMed  CAS  Google Scholar 

  6. Hughes GR. Migraine, memory loss, and “multiple sclerosis.” Neurological features of the antiphospholipid (Hughes’) syndrome. Postgrad Med J 2003;79:81–83.

    Article  PubMed  CAS  Google Scholar 

  7. Levine SR, Deegan MJ, Futrell N, Welch KM. Cerebrovascular and neurologic disease associated with antiphospholipid antibodies: 48 cases. Neurology 1990;40:1181–1189.

    PubMed  CAS  Google Scholar 

  8. Brey RL, Escalante A. Neurological manifestations of antiphospholipid antibody syndrome. Lupus 1998;7(suppl 2):S67–S74.

    Article  PubMed  Google Scholar 

  9. Cervera R, Piette JC, Font J, et al. Antiphospholipid syndrome: clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients. Arthritis Rheum 2002;46:1019–1027.

    Article  PubMed  Google Scholar 

  10. Sanna G, Bertolaccini ML, Cuadrado MJ, Khamashta MA, Hughes, GR. Central nervous system involvement in the antiphospholipid (Hughes) syndrome. Rheumatology (Oxford) 2003;42:200–213.

    Article  PubMed  CAS  Google Scholar 

  11. Katzav A, Chapman J, Shoenfeld Y. CNS dysfunction in the antiphospholipid syndrome. Lupus 2003;12:903–907.

    Article  PubMed  CAS  Google Scholar 

  12. Sastre-Garriga J, Montalban X. APS and the brain. Lupus 2003;12:877–882.

    Article  PubMed  CAS  Google Scholar 

  13. Chapman J, Rand JH, Brey RL, et al. Non-stroke neurological syndromes associated with antiphospholipid antibodies: evaluation of clinical and experimental studies. Lupus 2003;12:514–517.

    Article  PubMed  CAS  Google Scholar 

  14. Shoenfeld Y, Lev S, Blatt I, et al. Features associated with epilepsy in the antiphospholipid syndrome. J Rheumatol 2004;31:1344–1348.

    PubMed  Google Scholar 

  15. Sun KH, Liu WT, Tsai CY, et al. Inhibition of astrocyte proliferation and binding to brain tissue of anticardiolipin antibodies purified from lupus serum. Ann Rheum Dis 1992;51:707–712.

    Article  PubMed  CAS  Google Scholar 

  16. Khalili A, Cooper RC. A study of immune responses to myelin and cardiolipin in patients with systemic lupus erythematosus (SLE). Clin Exp Immunol 1991;85:365–372.

    Article  PubMed  CAS  Google Scholar 

  17. Oosting JD, Derksen RH, Blokzijl L, Sixma JJ, de Groot PG. Antiphospholipid antibody positive sera enhance endothelial cell procoagulant activity — studies in a thrombosis model. Thromb Haemost 1992;68:278–284.

    PubMed  CAS  Google Scholar 

  18. Simantov R, LaSala JM, Lo SK, et al. Activation of cultured vascular endothelial cells by antiphospholipid antibodies. J Clin Invest 1995;96:2211–2219.

    PubMed  CAS  Google Scholar 

  19. Del Papa N, Guidali L, Sala A, et al. Endothelial cells as target for antiphospholipid antibodies. Human polyclonal and monoclonal anti-beta 2-glycoprotein I antibodies react in vitro with endothelial cells through adherent beta 2-glycoprotein I and induce endothelial activation. Arthritis Rheum 1997;40:551–561.

    PubMed  Google Scholar 

  20. Meroni P, Tincani A, Sepp N, et al. Endothelium and the brain in CNS lupus. Lupus 2003;12:919–928.

    Article  PubMed  CAS  Google Scholar 

  21. Lai NS, Lan JL. Evaluation of cerebrospinal anticardiolipin antibodies in lupus patients with neuropsychiatric manifestations. Lupus 2000;9:353–357.

    Article  PubMed  CAS  Google Scholar 

  22. Blank M, Krause I, Fridkin M, et al. Bacterial induction of autoantibodies to beta2-glycoprotein-I accounts for the infectious etiology of antiphospholipid syndrome. J Clin Invest 2002;109:797–804.

    Article  PubMed  CAS  Google Scholar 

  23. Shrot S, Katzav A, Korczyn AD, et al. Behavioral and cognitive deficits occur only after prolonged exposure of mice to antiphospholipid antibodies. Lupus 2002;11:736–743.

    Article  PubMed  CAS  Google Scholar 

  24. Shoenfeld Y, Nahum A, Korczyn AD, et al. Neuronal-binding antibodies from patients with antiphospholipid syndrome induce cognitive deficits following intrathecal passive transfer. Lupus 2003;12:436–442.

    Article  PubMed  CAS  Google Scholar 

  25. Mackworth-Young CG, Hughes GRV. Epilepsy: an early symptom of systemic lupus erythematosus. J Neurol Neurosurg Psychiatry 1985;48:185.

    PubMed  CAS  Google Scholar 

  26. Inzelberg R, Korczyn AD. Lupus anticoagulant and the late onset seizures. Acta Neurol Scand 1989;79:114–118.

    Article  PubMed  CAS  Google Scholar 

  27. Herranz MT, Rivier G, Khamashta MA, Blaser KU, Hughes GR. Association between antiphospholipid antibodies and epilepsy in patients with systemic lupus erythematosus. Arthritis Rheum 1994;37:568–571.

    PubMed  CAS  Google Scholar 

  28. Toubi E, Khamashta MA, Panarra A, Hughes GR. Association of antiphospholipid antibodies with central nervous system disease in systemic lupus erythematosus. Am J Med 1995;99:397–401.

    Article  PubMed  CAS  Google Scholar 

  29. Liou HH, Wang CR, Chen CJ, et al. Elevated levels of anticardiolipin antibodies and epilepsy in lupus patients. Lupus 1996;5:307–312.

    PubMed  CAS  Google Scholar 

  30. Verrot D, San-Marco M, Dravet C, et al. Prevalence and signification of antinuclear and anticardiolipin antibodies in patients with epilepsy. Am J Med 1997;103:33–37.

    Article  PubMed  CAS  Google Scholar 

  31. Shrivastava A, Dwivedi S, Aggarwal A, Misra R. Anti-cardiolipin and anti-beta2 glycoprotein I antibodies in Indian patients with systemic lupus erythematosus: association with the presence of seizures. Lupus 2001;10:45–50.

    Article  PubMed  CAS  Google Scholar 

  32. Sanna G, Bertolaccini ML, Cuadrado MJ, et al. Neuropsychiatric manifestations in systemic lupus erythematosus: prevalence and association with antiphospholipid antibodies. J Rheumatol 2003;30:985–992.

    PubMed  Google Scholar 

  33. Jain KK. Systemic lupus erythematosus (SLE)-like syndromes associated with carbamazepine therapy. Drug Saf 1991;6:350–360.

    PubMed  CAS  Google Scholar 

  34. Echaniz-Laguna A, Thiriaux A, Ruolt-Olivesi I, Marescaux C, Hirsch E. Lupus anticoagulant induced by the combination of valproate and lamotrigine. Epilepsia 1999;40:1661–1663.

    Article  PubMed  CAS  Google Scholar 

  35. Peltola JT, Haapala A, Isojarvi JI, et al. Antiphospholipid and antinuclear antibodies in patients with epilepsy or new-onset seizure disorders. Am J Med 2000;109:712–717.

    Article  PubMed  CAS  Google Scholar 

  36. Eriksson K, Peltola J, Keranen T, Haapala AM, Koivikko M. High prevalence of antiphospholipid antibodies in children with epilepsy: a controlled study of 50 cases. Epilepsy Res 2001;46:129–137.

    Article  PubMed  CAS  Google Scholar 

  37. Ranua J, Luoma K, Peltola J, et al. Anticardiolipin and antinuclear antibodies in epilepsy-a population-based cross-sectional study. Epilepsy Res 2004;58:13–18.

    Article  PubMed  CAS  Google Scholar 

  38. Gibbs JW 3rd, Husain AM. Epilepsy associated with lupus anticoagulant. Seizure 2002;11:207–209.

    Article  PubMed  Google Scholar 

  39. Liou HH, Wang CR, Chou HC, et al. Anticardiolipin antisera from lupus patients with seizures reduce a GABA receptor-mediated chloride current in snail neurons. Life Sci 1994;54:1119–1125.

    Article  PubMed  CAS  Google Scholar 

  40. Chapman J, Cohen-Armon M, Shoenfeld Y, Korczyn AD. Antiphospholipid antibodies permeabilize and depolarize brain synaptoneurosomes. Lupus 1999;8:127–133.

    Article  PubMed  CAS  Google Scholar 

  41. Kent M, Alvarez F, Vogt E, Fyffe R, Ng AK, Rote N. Monoclonal antiphosphatidylserine antibodies react directly with feline and murine central nervous system. J Rheumatol 1997;24:1725–1733.

    PubMed  CAS  Google Scholar 

  42. Kent MN, Alvarez FJ, Ng AK, Rote NS. Ultrastructural localization of monoclonal antiphospholipid antibody binding to rat brain. Exp Neurol 2000;163:173–179.

    Article  PubMed  CAS  Google Scholar 

  43. Cuadrado MJ, Sanna G. Headache and systemic lupus erythematosus. Lupus 2003;12:943–946.

    Article  PubMed  CAS  Google Scholar 

  44. Levine SR, Joseph R, G, DA, Welch KM. Migraine and the lupus anticoagulant. Case reports and review of the literature. Cephalalgia 1987;7:93–99.

    Article  PubMed  CAS  Google Scholar 

  45. Hogan MJ, Brunet DG, Ford PM, Lillicrap D. Lupus anticoagulant, antiphospholipid antibodies and migraine. Can J Neurol Sci 1988;15:420–425.

    PubMed  CAS  Google Scholar 

  46. Alarcon-Segovia D, Deleze M, Oria CV, et al. Antiphospholipid antibodies and the antiphospholipid syndrome in systemic lupus erythematosus. A prospective analysis of 500 consecutive patients. Medicine (Baltimore) 1989;68:353–365.

    CAS  Google Scholar 

  47. Tzourio C, Kittner SJ, Bousser MG, Alperovitch A. Migraine and stroke in young women. Cephalalgia 2000;20:190–199.

    Article  PubMed  CAS  Google Scholar 

  48. Shuaib A, Barklay L, Lee MA, Suchowersky O. Migraine and anti-phospholipid antibodies. Headache 1989;29:42–45.

    Article  PubMed  CAS  Google Scholar 

  49. Tietjen GE. Migraine and antiphospholipid antibodies. Cephalalgia 1992;12:69–74.

    Article  PubMed  CAS  Google Scholar 

  50. Montalban J, Cervera R, Font J, et al. Lack of association between anticardiolipin antibodies and migraine in systemic lupus erythematosus. Neurology 1992;42:681–682.

    PubMed  CAS  Google Scholar 

  51. Tietjen GE, Day M, Norris L, et al. Role of anticardiolipin antibodies in young persons with migraine and transient focal neurologic events: a prospective study. Neurology 1998;50:1433–1440.

    PubMed  CAS  Google Scholar 

  52. Verrotti A, Cieri F, Pelliccia P, Morgese G, Chiarelli F. Lack of association between antiphospholipid antibodies and migraine in children. Int J Clin Lab Res 2000;30:109–111.

    Article  PubMed  CAS  Google Scholar 

  53. Cuadrado MJ, Khamashta MA, Hughes GRV. Migraine and stroke in young women. Q J Med 2000;93:317–318.

    CAS  Google Scholar 

  54. Cuadrado MJ, Khamashta MA, Hughes GR. Sticky blood and headache. Lupus 2001;10:392–393.

    Article  PubMed  CAS  Google Scholar 

  55. Hughes G, Cuadrado M, Khamashta M, Sanna G. Headache and memory loss: rapid response to heparin in the antiphospholipid syndrome. Lupus 2001;10:778.

    Article  PubMed  CAS  Google Scholar 

  56. Cuadrado MJ, Sanna G, Sharief M, Khamashta MA, Hughes GR. Double blind, crossover, randomised trial comparing low molecular weight heparin versus placebo in the treatment of chronic headache in patients with antiphospholipid antibodies [abstract]. Arthritis Rheum 2003;48:S364.

    Google Scholar 

  57. Denburg S, Denburg J. Cognitive dysfunction and antiphospholipid antibodies in systemic lupus erythematosus. Lupus 2003;12:883–890.

    Article  PubMed  CAS  Google Scholar 

  58. Hanly JG, Walsh NM, Fisk JD, et al. Cognitive impairment and autoantibodies in systemic lupus erythematosus. Br J Rheumatol 1993;32:291–296.

    PubMed  CAS  Google Scholar 

  59. Denburg SD, Carbotte RM, Ginsberg JS, Denburg JA. The relationship of antiphospholipid antibodies to cognitive function in patients with systemic lupus erythematosus. J Int Neuropsychol Soc 1997;3:377–386.

    PubMed  CAS  Google Scholar 

  60. Hanly JG, Hong C, Smith S, and Fisk JD. A prospective analysis of cognitive function and anticardiolipin antibodies in systemic lupus erythematosus. Arthritis Rheum 1999;728–734.

    Google Scholar 

  61. Menon S, Jameson-Shortall E, Newman SP, Hall-Craggs MR, Chinn R, Isenberg DA. A longitudinal study of anticardiolipin antibody levels and cognitive functioning in systemic lupus erythematosus. Arthritis Rheum 1999;42:735–741.

    Article  PubMed  CAS  Google Scholar 

  62. Asherson RA, Khamashta MA, Gil A, et al. Cerebrovascular disease and antiphospholipid antibodies in systemic lupus erythematosus, lupus-like disease, and the primary antiphospholipid syndrome. Am J Med 1989;86:391–399.

    Article  PubMed  CAS  Google Scholar 

  63. Kushner M, Simonian N. Lupus anticoagulants, anticardiolipin antibodies, and cerebral ischemia. Stroke 1989;20:225–229.

    PubMed  CAS  Google Scholar 

  64. Montalban J, Fernandez J, Arderiu A, et al. Multi-infarct dementia associated with antiphospholipid antibodies. Presentation of 2 cases. Med Clin (Barc) 1989;93:424–426.

    CAS  Google Scholar 

  65. Kurita A, Hasunuma T, Mochio S, Shimada T, Isogai Y, Kurahashi T. A young case with multiinfarct dementia associated with lupus anticoagulant. Intern Med 1994;33:373–375.

    PubMed  CAS  Google Scholar 

  66. Westerman EM, Miles JM, Backonja M, Sundstrom WR. Neuropathologic findings in multi-infarct dementia associated with anticardiolipin antibody. Evidence for endothelial injury as the primary event. Arthritis Rheum 1992;35:1038–1041.

    PubMed  CAS  Google Scholar 

  67. Hilker R, Thiel A, Geisen C, Rudolf J. Cerebral blood flow and glucose metabolism in multi-infarctdementia related to primary antiphospholipid antibody syndrome. Lupus 2000;9:311–316.

    Article  PubMed  CAS  Google Scholar 

  68. Mosek A, Yust I, Treves TA, Vardinon N, Korczyn AD, Chapman J. Dementia and antiphospholipid antibodies. Dement Geriatr Cogn Disord 2000;11:36–38.

    Article  PubMed  CAS  Google Scholar 

  69. Chapman J, Abu-Katash M, Inzelberg R, et al. Prevalence and clinical features of dementia associated with the antiphospholipid syndrome and circulating anticoagulants. J Neurol Sci 2002;203–204:81–84.

    Article  PubMed  Google Scholar 

  70. Wolkowitz OM, Reus VI, Canick J, Levin B, and Lupien S. Glucocorticoid medication, memory and steroid psychosis in medical illness. Ann N Y Acad Sci 1997;823:81–96.

    PubMed  CAS  Google Scholar 

  71. Wolkowitz OM, Reus VI, Weingartner H, et al. Cognitive effects of corticosteroids. Am J Psychiatry 1990;147:1297–1303.

    PubMed  CAS  Google Scholar 

  72. Schwartz M, Rochas M, Weller B, et al. High association of anticardiolipin antibodies with psychosis. J Clin Psychiatry 1998;59:20–23.

    PubMed  CAS  Google Scholar 

  73. Ziporen L, Shoenfeld Y, Levy Y, Korczyn AD. Neurological dysfunction and hyperactive behavior associated with antiphospholipid antibodies. A mouse model. J Clin Invest 1997;100:613–619.

    Article  PubMed  CAS  Google Scholar 

  74. Katzav A, Pick CG, Korczyn AD, et al. Hyperactivity in a mouse model of the antiphospholipid syndrome. Lupus 2001;10:496–499.

    Article  PubMed  CAS  Google Scholar 

  75. Bujanover S, Levy Y, Katz M, Leitner Y, Vinograd I, Shoenfeld Y. Lack of association between antiphospholipid antibodies (APLA) and Attention Deficit/Hyperactivity Disorder (ADHD) in children. Clin Dev Immunol 2003;10:105–109.

    Article  PubMed  CAS  Google Scholar 

  76. Fernando SJ. An attack of chorea complicating oral contraceptive therapy. Practitioner 1966;197:210–211.

    PubMed  CAS  Google Scholar 

  77. Agrawal BL, Foa RP. Collagen vascular disease appearing as chorea gravidarum. Arch Neurol 1982;39:192–193.

    PubMed  CAS  Google Scholar 

  78. Herd JK, Medhi M, Uzendoski DM, Saldivar VA. Chorea associated with systemic lupus erythematosus: report of two cases and review of the literature. Pediatrics 1978;61:308–315.

    PubMed  CAS  Google Scholar 

  79. Watanabe T, Onda H. Hemichorea with antiphospholipid antibodies in a patient with lupus nephritis. Pediatr Nephrol 2004;19:451–453.

    Article  PubMed  Google Scholar 

  80. Klawans HL, Weiner WJ. The pharmacology of choreatic movement disorders. Prog Neurobiol 1976;6:49–80.

    Article  PubMed  CAS  Google Scholar 

  81. Asherson RA, Hughes GRV. Antiphospholipid antibodies and chorea. J Rheumatol 1988;15:377–379.

    PubMed  CAS  Google Scholar 

  82. Cervera R, Asherson RA, Font J, et al. Chorea in the antiphospholipid syndrome. Clinical, radiologic, and immunologic characteristics of 50 patients from our clinics and the recent literature. Medicine (Baltimore) 1997;76:203–212.

    Article  CAS  Google Scholar 

  83. Scott TF, Hess D, and Brillman J. Antiphospholipid antibody syndrome mimicking multiple sclerosis clinically and by magnetic resonance imaging. Arch Intern Med 1994;154:917–920.

    Article  PubMed  CAS  Google Scholar 

  84. Ijdo J, Conti-Kelly AM, Greco P, et al. Anti-phospholipid antibodies in patients with multiple sclerosis and MS-like illnesses: MS or APS? Lupus 1999;8:109–115.

    Article  PubMed  CAS  Google Scholar 

  85. Cuadrado MJ, Khamashta MA, Ballesteros A, Godfrey T, Simon MJ, Hughes GRV. Can neurologic manifestations of Hughes (antiphospholipid) syndrome be distinguished from multiple sclerosis? Analysis of 27 patients and review of the literature. Medicine (Baltimore) 2000;79:57–68.

    Article  CAS  Google Scholar 

  86. Tourbah A, Clapin A, Gout O, et al. Systemic autoimmune features and multiple sclerosis: a 5-year follow-up study. Arch Neurol 1998;55:517–521.

    Article  PubMed  CAS  Google Scholar 

  87. Karussis D, Leker RR, Ashkenazi A, Abramsky O. A subgroup of multiple sclerosis patients with anticardiolipin antibodies and unusual clinical manifestations: do they represent a new nosological entity? Ann Neurol 1998;44:629–634.

    Article  PubMed  CAS  Google Scholar 

  88. Roussel V, Yi F, Jauberteau MO, et al. Prevalence and clinical significance of anti-phospholipid antibodies in multiple sclerosis: a study of 89 patients. J Autoimmun 2000;14:259–265.

    Article  PubMed  CAS  Google Scholar 

  89. Sastre-Garriga J, Reverter JC, Font J, Tintore M, Espinosa G, Montalban X. Anticardiolipin antibodies are not a useful screening tool in a nonselected large group of patients with multiple sclerosis. Ann Neurol 2001;49:408–411.

    Article  PubMed  CAS  Google Scholar 

  90. Lavalle C, Pizarro S, Drenkard C, Sanchez-Guerrero J, Alarcon-Segovia D. Transverse myelitis: a manifestation of systemic lupus erythematosus strongly associated with antiphospholipid antibodies. J Rheumatol 1990;17:34–37.

    PubMed  CAS  Google Scholar 

  91. Kovacs B, Lafferty TL, Brent LH, DeHoratius RJ. Transverse myelopathy in systemic lupus erythematosus: an analysis of 14 cases and review of the literature. Ann Rheum Dis 2000;59:120–124.

    Article  PubMed  CAS  Google Scholar 

  92. Sherer Y, Hassin S, Shoenfeld Y, et al. Transverse myelitis in patients with antiphospholipid antibodies-the importance of early diagnosis and treatment. Clin Rheumatol 2002;21:207–210.

    Article  PubMed  CAS  Google Scholar 

  93. D’Cruz D, Mellor-Pita S, Joven B, et al. Transverse myelitis as the first manifestation of systemic lupus erythematosus or lupus-like disease: good functional outcome and relevance of antiphospholipid antibodies. J Rheumatol 2004;31:280–285.

    PubMed  Google Scholar 

  94. Orefice G, De Joanna G, Coppola M, Brancaccio V, Ames PR. Benign intracranial hypertension: a non-thrombotic complication of the primary antiphospholipid syndrome? Lupus 1995;4:324–326.

    PubMed  CAS  Google Scholar 

  95. Sussman J, Leach M, Greaves M, Malia R, Davies-Jones GA. Potentially prothrombotic abnormalities of coagulation in benign intracranial hypertension. J Neurol Neurosurg Psychiatry 1997;62:229–233.

    Article  PubMed  CAS  Google Scholar 

  96. Leker RR, Steiner I. Anticardiolipin antibodies are frequently present in patients with idiopathic intracranial hypertension. Arch Neurol 1998;55:817–820.

    Article  PubMed  CAS  Google Scholar 

  97. Kesler A, Ellis MH, Reshef T, Kott E, Gadoth N. Idiopathic intracranial hypertension and anticardiolipin antibodies. J Neurol Neurosurg Psychiatry 2000;68:379–380.

    Article  PubMed  CAS  Google Scholar 

  98. Hisashi K, Komune S, Taira T, Uemura T, Sadoshima S, Tsuda, H. Anticardiolipin antibodyinduced sudden profound sensorineural hearing loss. Am J Otolaryngol 1993;14:275–277.

    Article  PubMed  CAS  Google Scholar 

  99. Casoli P, Tumiati B. Cogan’s syndrome: a new possible complication of antiphospholipid antibodies? Clin Rheumatol 1995;14:197–198.

    Article  PubMed  CAS  Google Scholar 

  100. Tumiati B, Casoli P. Sudden sensorineural hearing loss and anticardiolipin antibody. Am J Otolaryngol 1995;16:220.

    Article  PubMed  CAS  Google Scholar 

  101. Toubi E, Ben-David J, Kessel A, Podoshin L, Golan TD. Autoimmune aberration in sudden sensorineural hearing loss: association with anti-cardiolipin antibodies. Lupus 1997;6:540–542.

    PubMed  CAS  Google Scholar 

  102. Naarendorp M, Spiera H. Sudden sensorineural hearing loss in patients with systemic lupus erythematosus or lupus-like syndromes and antiphospholipid antibodies. J Rheumatol 1998;25:589–592.

    PubMed  CAS  Google Scholar 

  103. Gilburd B, Stein M, Tomer Y, et al. Autoantibodies to phospholipids and brain extract in patients with the Guillain-Barre syndrome: cross-reactive or pathogenic? Autoimmunity 1993;16:23–27.

    PubMed  CAS  Google Scholar 

  104. Montalban J, Arboix A, Staub H, et al. Transient global amnesia and antiphospholipid syndrome. Clin Exp Rheumatol 1989;7:85–87.

    PubMed  CAS  Google Scholar 

  105. Brey RL, Gharavi AE, Lockshin MD. Neurologic complications of antiphospholipid antibodies. Rheum Dis Clin North Am 1993;19:833–850.

    PubMed  CAS  Google Scholar 

  106. Frohman L, Turbin R, Bielory L, Wolansky L, Lambert WC, Cook S. Autoimmune optic neuropathy with anticardiolipin antibody mimicking multiple sclerosis in a child. Am J Ophthalmol 2003;136:358–360.

    Article  PubMed  Google Scholar 

  107. Reino S, Munoz-Rodriguez FJ, Cervera R, Espinosa G, Font J, Ingelmo M. Optic neuropathy in the “primary” antiphospholipid syndrome: report of a case and review of the literature. Clin Rheumatol 1997;16:629–631.

    Article  PubMed  CAS  Google Scholar 

  108. Giorgi D, Gabrieli CB, Bonomo L. The clinical-ophtalmological spectrum of antiphospholipid syndrome. Ocular Immunol Inflamm 1998;6:269–273.

    Article  CAS  Google Scholar 

  109. Wiechens B, Schroder JO, Potzsch B, Rochels R. Primary antiphospholipid antibody syndrome and retinal occlusive vasculopathy. Am J Ophthalmol 1997;123:848–850.

    PubMed  CAS  Google Scholar 

  110. Au A, O’Day J. Review of severe vaso-occlusive retinopathy in systemic lupus erythematosus and the antiphospholipid syndrome: associations, visual outcomes, complications and treatment. Clin Exp Ophthalmol 2004;32:87–100.

    Article  Google Scholar 

  111. Milanov IG, Rashkov R, Baleva M, Georgiev D. Antiphospholipid syndrome and parkinsonism. Clin Exp Rheumatol 1998;16:623–624.

    PubMed  CAS  Google Scholar 

  112. Milanov I, Bogdanova D. Antiphospholipid syndrome and dystonia-parkinsonism. A case report. Parkinsonism Relat Disord 2001;7:139–141.

    Article  PubMed  Google Scholar 

  113. Adhiyaman V, Meara RJ, Bhowmick BK. Antiphospholipid syndrome and dystonia-parkinsonism: need for anticoagulation. Parkinsonism Relat Disord 2002;8:215.

    Article  PubMed  CAS  Google Scholar 

  114. Aleem MA, Govindaraj K, Senthil VJ, Kanagaraj V, Jayapal V. Primary antiphopholipid syndrome presenting as pseudobulbar palsy in a young male. J Assoc Physicians India 2001;49:1036–1038.

    PubMed  CAS  Google Scholar 

  115. Reiblat T, Polishchuk I, Dorodnikov E, et al. Primary antiphospholipid antibody syndrome masquerading as progressive supranuclear palsy. Lupus 2003;12:67–69.

    Article  Google Scholar 

  116. Sanna G, Piga M, Terryberry JW, et al. Central nervous system involvement in systemic lupus erythematosus: cerebral imaging and serological profile in patients with and without overt neuropsychiatric manifestations. Lupus 2000;9:573–583.

    Article  PubMed  CAS  Google Scholar 

  117. Stimmler MM, Coletti PM, Quismorio FPJ. Magnetic resonance imaging of the brain in neuropsychiatric systemic lupus erythematosus. Semin Arthritis Rheum 1993;22:335–349.

    PubMed  CAS  Google Scholar 

  118. Vermeer SE, Hollander M, van Dijk EJ, Hofman A, Koudstaal PJ, Breteler MM. Silent brain infarcts and white matter lesions increase stroke risk in the general population: the Rotterdam Scan Study. Stroke 2003;34:1126–1129.

    Article  PubMed  Google Scholar 

  119. Vermeer SE, Prins ND, den Heijer T, Hofman A, Koudstaal PJ, Breteler MM. Silent brain infarcts and the risk of dementia and cognitive decline. N Engl J Med 2003;348:1215–1222.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Rheumatology, Homerton University Hospital NHS, Foundation Trust, London, UK

    Giovanni Sanna MD, PhD

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  1. Lupus Research Unit, St Thomas’ Hospital, London, UK

    M. A. Khamashta MD, FRCP, PhD (Deputy Head) (Deputy Head)

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© 2006 Springer-Verlag London Limited

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Sanna, G. (2006). Cerebral Disease Other than Stroke and Transient Ischemic Attack in Antiphospholipid Syndrome. In: Khamashta, M.A. (eds) Hughes Syndrome. Springer, London. https://doi.org/10.1007/1-84628-009-5_7

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  • DOI: https://doi.org/10.1007/1-84628-009-5_7

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-85233-873-2

  • Online ISBN: 978-1-84628-009-2

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