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Osteoarticular Manifestations of Antiphospholipid Syndrome

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Hughes Syndrome

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Conclusion

Diverse conditions associated with thrombotic lesions either in large vessels or in the microvasculature may be part of the APS clinical spectrum. Besides the classic clinical manifestations, including arterial and venous thrombosis or recurrent fetal loss, a number of other clinical conditions characterized as microangiopathic syndromes have been associated with APS. These syndromes can affect several organs including skin, brain, heart, and kidneys. Osteonecrosis may be another distinct clinical feature of APS associated with arterial or venous microthrombosis. Clinicians should be aware of the possible association between APS and osteonecrosis because early diagnosis may lead to early and proper management of this disabling disease. Patients with persistent symptoms originating from sites most susceptible to osteonecrosis should undergo MRI evaluation. A systematic screening for aPL in all cases with diagnosed osteonecrosis in the absence of precipitating factors should also be considered.

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  1. Department of Pathophysiology, Medical School, National University of Athens, Athens, Greece

    Maria G. Tektonidou MD & Haralampos M. Moutsopoulos MD, FACP, FRCP

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  1. Lupus Research Unit, St Thomas’ Hospital, London, UK

    M. A. Khamashta MD, FRCP, PhD (Deputy Head) (Deputy Head)

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Tektonidou, M.G., Moutsopoulos, H.M. (2006). Osteoarticular Manifestations of Antiphospholipid Syndrome. In: Khamashta, M.A. (eds) Hughes Syndrome. Springer, London. https://doi.org/10.1007/1-84628-009-5_12

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