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Protein Aggregation in Aging and Age-Related Neurodegenerative Disorders

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Prevention and Treatment of Age-related Diseases

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Abstract

The purpose of this chapter is to provide a background on the effects of aging on proteolytic pathways and protein aggregation, and to discuss the contribution of altered protease function and protein aggregation to brain function. Studies will focus on the proteasome proteolytic pathway. Lastly, these studies will also discuss the relationship between aging and age-related neurodegenerative disorders

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Authors and Affiliations

  1. Anatomy and Neurobiology Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA

    Jeffrey N. Keller & Qunxing Ding

  2. Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40536–0203

    Jeffrey N. Keller

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  1. Jeffrey N. Keller
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Editors and Affiliations

  1. Danish Centre for Molecular Gerontology, University of Aarhus, Denmark

    Suresh I.S. Rattan

  2. University Hospital of Odense, Denmark

    Moustapha Kassem

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Keller, J.N., Ding, Q. (2006). Protein Aggregation in Aging and Age-Related Neurodegenerative Disorders. In: Rattan, S.I., Kassem, M. (eds) Prevention and Treatment of Age-related Diseases. Springer, Dordrecht. https://doi.org/10.1007/1-4020-5058-5_15

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