Conclusions
Introduction of proteomic technologies has added a useful dimension to drug discovery. Proteomics technologies are useful in two important therapeutic areas: cancer and central nervous system. By helping to elucidate the pathomechanism of diseases, proteomics will help the discovery of rational medications that will fit in with the future concept of personalized medicines.
Proteomics technologies are not used alone but rather they are integrated with genomic and chemical approaches. Finally, bioinformatics plays an important role in drug discovery.
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References
Civelli, O., Saito, Y., Lin, S., et al, 2001, The orphan receptor strategy and the discovery of novel neuropeptides. Trends in Neurosciences 24: 230–237.
Ficarro, S.B., McCleland, M.L., Stukenberg, P.T., et al, 2002, Phosphoproteome analysis by mass spectrometry and its application to Saccharomyces cerevisiae. Nature Biotechnology 20: 301–305.
Gorg A., Obermaier C., Boguth G., et al, 2000, The current state of two-dimensional electrophoresis with immobilized pH gradients. Electrophoresis. 21: 1037–53.
Gygi, S.P., Rist, B., Gerber, S.A., et al, 1999, Quantitative analysis of protein mixtures using isotope coded affinity tags. Nature Biotechnology 17: 994–999.
Ideker, T., Thorsson, V., Ranish, J.A., et al, 2001, Integrated genomic and proteomic analyses of a systematically perturbed metabolic network. Science 292: 929–34.
Jain, K. K., 2003, Proteomics: Technologies, Markets and Companies. Jain Pharma Biotech Publications, Basel.
Jain, K. K., 2002a, Application of Laser Capture Microdissection to Proteomics. Methods in Enzymology. 356: 157–167.
Jain, K. K., 2002b, Proteomics-based anticancer drug discovery and development. Techn Cancer Res & Dev 1: 231–236.
Jain, K. K., 2002c, Role of Neuroproteomics in CNS Drug Discovery. Targets 1: 95–101.
Lach-Trifilieff, E., McKay, R.A., Monia, B.P., et al, 2001, In vitro and in vivo inhibition of interleukin (IL)-5-mediated eosinopoiesis by murine IL-5R alpha antisense oligonucleotide. Am J Respir Cell Mol Biol 24: 116–22.
McBeath, G., 2001, Chemical genomics: what will it take and who gets to play? Genome Biology 2: 2005.1–2005.6.
McDonald, W.H. and Yates, J.R. 3rd, 2002, Shotgun proteomics and biomarker discovery. Dis Markers. 18: 99–105.
Moseley, M.A., 2001, Current trends in differential expression proteomics: isotopically coded tags. Trends in Biotechnology 19 Suppl:S10–S16.
Nattkemper, T.W., Ritter, H.J., Schubert, W., 2001, A neural classifier enabling high-throughput topological analysis of lymphocytes in tissue sections. IEEE Trans Inf Technol Biomed. 5: 138–49.
Raamsdonk, L.M., Teusink, B., Broadhurst, D., et al, 2001, A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations. Nature Biotechnol 19: 45–50.
Resing, K. A., 2002, Analysis of signaling pathways using functional proteomics. Ann N Y Acad Sci 971: 608–14.
Rubenwolf, S., Niewohner, J., Meyer, E., et al, 2002, Functional proteomics using chromophore-assisted laser inactivation. Proteomics. 2: 241–6.
Salomon, A.R., Ficarro, S.B., Brill, L.M., et al, 2003, Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry. PNAS USA 100: 443–8.
Zheng, X.F.S., Chan., T.F., 2002, Chemical genomics in the global study of protein functions. Drug Discovery Today 7: 197–205.
Ziauddin, J. and Sabatini, D.M., 2001, Microarrays of cells expressing defined cDNAs. Nature. 411: 107–10.
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Jain, K.K. (2004). Applications of Proteomics Technologies for Drug Discovery. In: Hondermarck, H. (eds) Proteomics: Biomedical and Pharmaceutical Applications. Springer, Dordrecht. https://doi.org/10.1007/1-4020-2323-5_9
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