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Leukemia Inhibitory Factor in Reproduction

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Immunology of Pregnancy

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References

  1. Hilton DJ, Gough NM. Leukemia inhibitory factor: A biological perspective. J Cell Biochem 1991; 46(1):21–26.

    PubMed  CAS  Google Scholar 

  2. Hilton DJ, Nicola NA. Kinetic analyses of the binding of leukemia inhibitory factor to receptor on cells and membranes and in detergent solution. J Biol Chem 1992; 267(15):10238–10247.

    PubMed  CAS  Google Scholar 

  3. Gearing DP, Gough NM, King JA et al. Molecular cloning and expression of cDNA encoding a murine myeloid leukaemia inhibitory factor (LIF). Embo J 1987; 6(13):3995–4002.

    PubMed  CAS  Google Scholar 

  4. Metcalf D. The leukemia inhibitory factor (LIF). Int J Cell Cloning 1991; 9(2):95–108.

    PubMed  CAS  Google Scholar 

  5. Willson TA, Metcalf D, Gough NM. Cross-species comparison of the sequence of the leukaemia inhibitory factor gene and its protein. Eur J Biochem 1992; 204(1):21–30.

    PubMed  CAS  Google Scholar 

  6. Sutherland GR, Baker E, Hyland VJ et al. The gene for human leukemia inhibitory factor (LIF) maps to 22ql2. Leukemia 1989; 3(1):9–13.

    PubMed  CAS  Google Scholar 

  7. Stahl J, Gearing DP, Willson TA et al. Structural organization of the genes for murine and human leukemia inhibitory factor. Evolutionary conservation of coding and noncoding regions. J Biol Chem 1990; 265(15):8833–8841.

    PubMed  CAS  Google Scholar 

  8. Moreau JF, Donaldson DD, Bennett F et al. Leukaemia inhibitory factor is identical to the myeloid growth factor human interleukin for DA cells. Nature 1988; 336(6200):690–692.

    PubMed  CAS  Google Scholar 

  9. Gough NM, Gearing DP, King JA et al. Molecular cloning and expression of the human homologue of the murine gene encoding myeloid leukemia-inhibitory factor. Proc Natl Acad Sci USA 1988; 85(8):2623–2627.

    PubMed  CAS  Google Scholar 

  10. Gearing DP. The leukemia inhibitory factor and its receptor. Adv Immunol 1993; 53:31–58.

    PubMed  CAS  Google Scholar 

  11. Pennica D, Shaw KJ, Swanson TA et al. Cardiotrophin-1. Biological activities and binding to the leukemia inhibitory factor receptor/gpl30 signaling complex. J Biol Chem 1995; 270(18):10915–10922.

    PubMed  CAS  Google Scholar 

  12. Piquet-Pellorce C, Grey L, Mereau A et al. Are LIF and related cytokines functionally equivalent? Exp Cell Res 1994; 213(2):340–347.

    PubMed  CAS  Google Scholar 

  13. Kishimoto T, Taga T, Akira S. Cytokine signal transduction. Cell 1994; 76(2):253–262.

    PubMed  CAS  Google Scholar 

  14. Gearing DP, Ziegler SF, Comeau MR et al. Proliferative responses and binding properties of hematopoietic cells transfected with low-affinity receptors for leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor. Proc Natl Acad Sci USA 1994; 91(3):1119–1123.

    PubMed  CAS  Google Scholar 

  15. Hilton DJ, Nicola NA, Metcalf D. Distribution and comparison of receptors for leukemia inhibitory factor on murine hemopoietic and hepatic cells. J Cell Physiol 1991; 146(2):207–215.

    PubMed  CAS  Google Scholar 

  16. Charnock-Jones DS, Sharkey AM, Fenwick P et al. Leukaemia inhibitory factor mRNA concentration peaks in human endometrium at the time of implantation and the blastocyst contains mRNA for the receptor at this time. J Reprod Fertil 1994; 101(2):421–426.

    PubMed  CAS  Google Scholar 

  17. Kojima K, Kanzaki H, Iwai M et al. Expression of leukaemia inhibitory factor (LIF) receptor in human placenta: A possible role for LIF in the growth and differentiation of trophoblasts. Hum Reprod 1995; 10(7):1907–1911.

    PubMed  CAS  Google Scholar 

  18. Cullinan EB, Abbondanzo SJ, Anderson PS et al. Leukemia inhibitory factor (LIF) and LIF receptor expression in human endometrium suggests a potential autocrine/paracrine function in regulating embryo implantation. Proc Natl Acad Sci USA 1996; 93(7):3115–3120.

    PubMed  CAS  Google Scholar 

  19. Tomida M, Yamamoto-Yamaguchi Y, Hozumi M. Purification of a factor inducing differentiation of mouse myeloid leukemic Ml cells from conditioned medium of mouse fibroblast L929 cells. J Biol Chem 1984; 259(17):10978–10982.

    PubMed  CAS  Google Scholar 

  20. Anegon I, Moreau JF, Godard A et al. Production of human interleukin for DA cells (HILDA)/ leukemia inhibitory factor (LIF) by activated monocytes. Cell Immunol 1990; 130(1):50–65.

    PubMed  CAS  Google Scholar 

  21. Wetzler M, Talpaz M, Lowe DG et al. Constitutive expression of leukemia inhibitory factor RNA by human bone marrow stromal cells and modulation by IL-1, TNF-alpha, and TGF-beta. Exp Hematol 1991; 19(5):347–351.

    PubMed  CAS  Google Scholar 

  22. Allan EH, Hilton DJ, Brown MA et al. Osteoblasts display receptors for and responses to leukemia-inhibitory factor. J Cell Physiol 1990; 145(1):110–119.

    PubMed  CAS  Google Scholar 

  23. Wesselingh SL, Gough NM, Finlay-Jones JJ et al. Detection of cytokine mRNA in astrocyte cultures using the polymerase chain reaction. Lymphokine Res 1990; 9(2):177–185.

    PubMed  CAS  Google Scholar 

  24. Murray R, Lee F, Chiu CP. The genes for leukemia inhibitory factor and interleukin-6 are expressed in mouse blastocysts prior to the onset of hemopoiesis. Mol Cell Biol 1990; 10(9):4953–4956.

    PubMed  CAS  Google Scholar 

  25. Arici A, Engin O, Attar E et al. Modulation of leukemia inhibitory factor gene expression and protein biosynthesis in human endometrium. J Clin Endocrinol Metab 1995; 80(6):1908–1915.

    PubMed  CAS  Google Scholar 

  26. Arici A, Oral E, Bahtiyar O et al. Leukaemia inhibitory factor expression in human follicular fluid and ovarian cells. Hum Reprod 1997; 12(6):1233–1239.

    PubMed  CAS  Google Scholar 

  27. Keltz MD, Attar E, Buradagunta S et al. Modulation of leukemia inhibitory factor gene expression and protein biosynthesis in the human fallopian tube. Am J Obstet Gynecol 1996; 175(6):1611–1619.

    PubMed  CAS  Google Scholar 

  28. Metcalf D, Nicola NA, Gearing DP. Effects of injected leukemia inhibitory factor on hematopoietic and other tissues in mice. Blood 1990; 76(1):50–56.

    PubMed  CAS  Google Scholar 

  29. Metcalf D, Gearing DP. Fatal syndrome in mice engrafted with cells producing high levels of the leukemia inhibitory factor. Proc Natl Acad Sci USA 1989; 86(15):5948–5952.

    PubMed  CAS  Google Scholar 

  30. Mori M, Yamaguchi K, Abe K. Purification of a lipoprotein lipase-inhibiting protein produced by a melanoma cell line associated with cancer cachexia. Biochem Biophys Res Commun 1989; 160(3):1085–1092.

    PubMed  CAS  Google Scholar 

  31. Baumann H, Wong GG. Hepatocyte-stimulating factor III shares structural and functional identity with leukemia-inhibitory factor. J Immunol 1989; 143(4):1163–1167.

    PubMed  CAS  Google Scholar 

  32. Yamamori T, Fukada K, Aebersold R et al. The cholinergic neuronal differentiation factor from heart cells is identical to leukemia inhibitory factor. Science 1989; 246(4936):1412–1416.

    PubMed  CAS  Google Scholar 

  33. Murphy M, Reid K, Hilton DJ et al. Generation of sensory neurons is stimulated by leukemia inhibitory factor. Proc Natl Acad Sci USA 1991; 88(8):3498–3501.

    PubMed  CAS  Google Scholar 

  34. Arai K, Nishida J, Hayashida K et al. Coordinate regulation of immune and inflammatory responses by cytokines. Rinsho Byori 1990; 38(4):347–353.

    PubMed  CAS  Google Scholar 

  35. Bhatt H, Brunet LJ, Stewart CL. Uterine expression of leukemia inhibitory factor coincides with the onset of blastocyst implantation. Proc Natl Acad Sci USA 1991; 88(24):11408–11412.

    PubMed  CAS  Google Scholar 

  36. Shen MM, Leder P. Leukemia inhibitory factor is expressed by the preimplantation uterus and selectively blocks primitive ectoderm formation in vitro. Proc Natl Acad Sci USA 1992; 89(17):8240–8244.

    PubMed  CAS  Google Scholar 

  37. Smith AG, Heath JK, Donaldson DD et al. Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides. Nature 1988; 336(6200):688–690.

    PubMed  CAS  Google Scholar 

  38. Williams RL, Hilton DJ, Pease S et al. Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells. Nature 1988; 336(6200):684–687.

    PubMed  CAS  Google Scholar 

  39. Stewart CL. Leukaemia inhibitory factor and the regulation of preimplantation development of the mammalian embryo. Mol Reprod Dev 1994; 39(2):233–238.

    PubMed  CAS  Google Scholar 

  40. Vogiagis D, Fry RC, Sandeman RM et al. Leukaemia inhibitory factor in endometrium during the oestrous cycle, early pregnancy and in ovariectomized steroid-treated ewes. J Reprod Fertil 1997; 109(2):279–288.

    PubMed  CAS  Google Scholar 

  41. Yue ZP, Yang ZM, Wei P et al. Leukemia inhibitory factor, leukemia inhibitory factor receptor, and glycoprotein 130 in rhesus monkey uterus during menstrual cycle and early pregnancy. Biol Reprod 2000; 63(2):508–512.

    PubMed  CAS  Google Scholar 

  42. Cooke ID. Failure of implantation and its relevance to subfertility. J Reprod Fertil Suppl 1988; 36:155–159.

    PubMed  CAS  Google Scholar 

  43. Kliman H, Feinberg R. Trophoblast differentiation. In: Barnea E, Hustin J, Jauniaux E, eds. The First Twelve Weeks of Gestation. New York: Springer-Verlag, 1992.

    Google Scholar 

  44. Simon C, Pellicer A. Regulators of Implantation. Oxford UK: Oxford University Press, 1995.

    Google Scholar 

  45. Cross JC, Werb Z, Fisher SJ. Implantation and the placenta: Key pieces of the development puzzle. Science 1994; 266:1508–1518.

    PubMed  CAS  Google Scholar 

  46. Pollard JW, Hunt JS, Wiktor-Jedrzejczak W et al. A pregnancy defect in the osteopetrotic (op/op) mouse demonstrates the requirement for CSF-1 in female fertility. Dev Biol 1991; 148(1):273–283.

    PubMed  CAS  Google Scholar 

  47. Stewart CL, Kaspar P, Brunet LJ et al. Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor. Nature 1992; 359(6390):76–79.

    PubMed  CAS  Google Scholar 

  48. Carlos S, Frances A, Piquette G et al. Embryonic implantation in mice is blocked by interleukin-1 receptor antagonist. Endocrinology 1994; 134(2):521–528.

    Google Scholar 

  49. Kauma S, Matt D, Strom S et al. Interleukin-1 beta, human leukocyte antigen HLA-DR alpha, and transforming growth factor-beta expression in endometrium, placenta, and placental membranes. Am J Obstet Gynecol 1990; 163(5 Pt 1);1430–1437.

    PubMed  CAS  Google Scholar 

  50. Simon C, Piquette GN, Frances A et al. Interleukin-1 type I receptor messenger ribonucleic acid expression in human endometrium throughout the menstrual cycle. Fertil Steril 1993; 59(4):791–796.

    PubMed  CAS  Google Scholar 

  51. Kojima K, Kanzaki H, Iwai M et al. Expression of leukemia inhibitory factor in human endometrium and placenta. Biol Reprod 1994; 50(4):882–887.

    PubMed  CAS  Google Scholar 

  52. Vogiagis D, Marsh MM, Fry RC et al. Leukaemia inhibitory factor in human endometrium through-out the menstrual cycle. J Endocrinol 1996; 148(1):95–102.

    PubMed  CAS  Google Scholar 

  53. Chen DB, Hilsenrath R, Yang ZM et al. Leukaemia inhibitory factor in human endometrium during the menstrual cycle: Cellular origin and action on production of glandular epithelial cell prostaglandin in vitro. Hum Reprod 1995; 10(4):911–918.

    PubMed  CAS  Google Scholar 

  54. Eijk MJT, Mandlebaum J, Salat-Baroux J. Expression of leukaemia receptor subunits LIFRβ and gp 130 in human oocytes and preimplantation embryos. Mol Hum Reprod 1996; 2:355–360.

    PubMed  Google Scholar 

  55. Sharkey AM, Dellow K, Blayney M et al. Stage-specific expression of cytokine and receptor messenger ribonucleic acids in human preimplantation embryos. Biol Reprod 1995; 53(4):974–981.

    PubMed  CAS  Google Scholar 

  56. Simon C, Frances A, Piquette G et al. Interleukin-1 system in the materno-trophoblast unit in human implantation: Immunohistochemical evidence for autocrine/paracrine function. J Clin Endocrinol Metab 1994; 78(4):847–854.

    PubMed  CAS  Google Scholar 

  57. Chen HL, Yang YP, Hu XL et al. Tumor necrosis factor alpha mRNA and protein are present in human placental and uterine cells at early and late stages of gestation. Am J Pathol 1991; 139(2):327–335.

    PubMed  CAS  Google Scholar 

  58. Svalander PC, Holmes PV, Olovsson M et al. Platelet-derived growth factor is detected in human blastocyst culture medium but not in human follicular fluid—a preliminary report. Fertil Steril 1991; 56(2):367–369.

    PubMed  CAS  Google Scholar 

  59. Selick CE, Horowitz GM, Gratch M et al. Immunohistochemical localization of transforming growth factor-beta in human implantation sites. J Clin Endocrinol Metab 1994; 78(3):592–596.

    PubMed  CAS  Google Scholar 

  60. Hambartsoumian E, Taupin JL, Moreau JF et al. In-vivo administration of progesterone inhibits the secretion of endometrial leukaemia inhibitory factor in vitro. Mol Hum Reprod 1998; 4(11):1039–1044.

    PubMed  CAS  Google Scholar 

  61. Piccinni MP, Scaletti C, Maggi E et al. Role of hormone-controlled Th1-and Th2-type cytokines in successful pregnancy. J Neuroimmunol 2000; 109(1):30–33.

    PubMed  CAS  Google Scholar 

  62. Giudice LC, Cataldo NA, van Dessel HJ et al. Growth factors in normal ovarian follicle development. Semin Reprod Endocrinol 1996; 14(3):179–196.

    PubMed  CAS  Google Scholar 

  63. Strickland S, Richards W. Invasion of the trophoblasts. Cell 1992; 71:355–357.

    PubMed  CAS  Google Scholar 

  64. Kliman H. Placental hormones. Infertil Reprod Med 1994; 5:591–610.

    Google Scholar 

  65. Ringler G, Kao L, Miller W et al. Effects of 8-bromo-cAMP on expression of endocrine functions by cultured human trophoblast cells. Regulation of specific mRNAs. Mol Cell Endocrinol 1989; 61:13–21.

    PubMed  CAS  Google Scholar 

  66. Feldman GM, Petricoin 3rd EF, David M et al. Cytokines that associate with the signal transducer gpl30 activate the interferon-induced transcription factor p91 by tyrosine phosphorylation. J Biol Chem 1994; 269(14):10747–10752.

    PubMed  CAS  Google Scholar 

  67. Ulloa A, August A, Golos T et al. 8-Bromo-adenosine 3′,5′-monophosphate regulates expression of chorionic gonadotropin and fibronectin in human cytotrophoblasts. J Clin Endocrinol Metab 1987; 64:1002–1009.

    Google Scholar 

  68. Maruo T, Matsuo H, Oishi T et al. Induction of differentiated trophoblast function by epidermal growth factor: Relation of histochemically detected cellular epidermal growth factor receptor levels. J Clin Endocrinol Metab 1987; 64:744–750.

    PubMed  CAS  Google Scholar 

  69. Shi Q, Lei Z, Rao C et al. Novel role of human chorionic gonadotropin in differentiation of human cytotrophoblasts. Endocrinology 1993; 132:1387–1395.

    PubMed  CAS  Google Scholar 

  70. Morrish D, Bhardwaj D, Paras M. Transforming growth factor βl inhibits placental differentiation and human chorionic gonadotropin and human placental lactogen secretion. Endocrinology 1991; 129:22–26.

    PubMed  CAS  Google Scholar 

  71. Feinberg RF, Kliman HJ, Wang CL. Transforming growth factor-beta stimulates trophoblast oncofetal fibronectin synthesis in vitro: Implications for trophoblast implantation in vivo. J Clin Endocrinol Metab 1994; 78(5):1241–1248.

    PubMed  CAS  Google Scholar 

  72. Nachtigall MJ, Kliman HJ, Feinberg RF et al. The effect of leukemia inhibitory factor (LIF) on trophoblast differentiation: A potential role in human implantation. J Clin Endocrinol Metab 1996; 81(2):801–806.

    PubMed  CAS  Google Scholar 

  73. Fisher S, Cui T, Zhang L et al. Adhesive and degradative properties of human placental cytotrophoblast cells in vitro. J Cell Biol 1989; 109:891–902.

    PubMed  CAS  Google Scholar 

  74. Milwidski A, Finci Y, Yagel S et al. Gonatropin-mediated inhibition of proteolytic enzymes pro duced by human trophoblast in culture. Journal of Clinical Endocrinology and Metabolism 1993; 76:1101–1105.

    Google Scholar 

  75. Queenan J, Kao L-C, Arboleda C et al. Regulation of urokinase-type plasminogen activator production by cultured human cytotrophoblasts. Journal of Biological Chemistry 1987; 262:10903–10906.

    PubMed  CAS  Google Scholar 

  76. Feinberg RF, Kao LC, Haimowitz JE et al. Plasminogen activator inhibitor types 1 and 2 in human trophoblasts. Laboratory Investigation 1989; 61:20–26.

    PubMed  CAS  Google Scholar 

  77. Albrecht E, Pepe G. Placental steroid hormone biosynthesis in primate pregnancy. Endocrinology Reviews 1990; 11:124–150.

    CAS  Google Scholar 

  78. Van Voorhis BJ, Syrop CH, Vincent Jr RD et al. Tubal versus uterine transfer of cryopreserved embryos: A prospective randomized trial. Fertil Steril 1995; 63(3):578–583.

    PubMed  Google Scholar 

  79. Bongso A, Ng SC, Fong CY et al. Improved pregnancy rate after transfer of embryos grown in human fallopian tubal cell coculture. Fertil Steril 1992; 58(3):569–574.

    PubMed  CAS  Google Scholar 

  80. Fry RC. The effect of leukaemia inhibitory factor (LIF) on embryogenesis. Reprod Fertil Dev 1992; 4(4):449–458.

    PubMed  CAS  Google Scholar 

  81. Toth M, Jeremias J, Ledger WJ et al. In vivo tumor necrosis factor production in women with salpingitis. Surg Gynecol Obstet 1992; 174(5):359–362.

    PubMed  CAS  Google Scholar 

  82. McGee ZA, Clemens CM, Jensen RL et al. Local induction of tumor necrosis factor as a molecular mechanism of mucosal damage by gonococci. Microb Pathog 1992; 12(5):333–341.

    PubMed  CAS  Google Scholar 

  83. Attar E, Ozsait B, Bulgurcuoglu S et al. Effect of leukaemia inhibitory factor on long-term sperm motility and survival. Reprod Biomed Online 2003; 7(1):71–74.

    PubMed  CAS  Google Scholar 

  84. Brannstrom M, Norman RJ. Involvement of leukocytes and cytokines in the ovulatory process and corpus luteum function. Human Reproduction 1993; 8:1762–1775.

    PubMed  CAS  Google Scholar 

  85. Adashi EY. Endocrinology of the ovary. Human Reproduction 1994; 9(5):815–827.

    PubMed  CAS  Google Scholar 

  86. Fakih H, Vijayakumar R. Improved pregnancy rates and outcome with gamete intrafallopian transfer when follicular fluid is used as a sperm capacitation and gamete transfer medium. Fertility and Sterility 1990; 53:515–520.

    PubMed  CAS  Google Scholar 

  87. Hemmings R, Lachapelle MH, Falcone T et al. Effect of follicular fluid supplementation on the in vitro development of human preembryos. Fertility and Sterility 1994; 62:1018–1021.

    PubMed  CAS  Google Scholar 

  88. Coskun S, Uzumcu M, Jaroudi K et al. Presence of leukemia inhibitory factor and interleukin-12 in human follicular fluid during follicular growth. Am J Reprod Immunol 1998; 40(1):13–18.

    PubMed  CAS  Google Scholar 

  89. Ozornek MH, Bielfeld P, Krussel JS et al. Epidermal growth factor and leukemia inhibitory factor levels in follicular fluid. Association with in vitro fertilization outcome. J Reprod Med 1999; 44(4):367–369.

    PubMed  CAS  Google Scholar 

  90. Dokras A, Sargent IL, Barlow DH. Human blastocyst grading: An indicator of developmental potential? Hum Reprod 1993; 8(12):2119–2127.

    PubMed  CAS  Google Scholar 

  91. Menezo Y, Hazout A, Dumont M et al. Coculture of embryos on Vero cells and transfer of blastocysts in humans. Hum Reprod 1992; 1:101–106.

    Google Scholar 

  92. Olivennes F, Hazout A, Lelaidier C et al. Four indications for embryo transfer at the blastocyst stage. Hum Reprod 1994; 9(12):2367–2373.

    PubMed  CAS  Google Scholar 

  93. Menezo YJ, Guerin JF, Czyba JC. Improvement of human early embryo development in vitro by coculture on monolayers of Vero cells. Biol Reprod 1990; 42(2):301–306.

    PubMed  CAS  Google Scholar 

  94. Gardner DK, Lane M. Amino acids and ammonium regulate mouse embryo development in culture. Biol Reprod 1993; 48(2):377–385.

    PubMed  CAS  Google Scholar 

  95. Gardner DK, Lane M, Spitzer A et al. Enhanced rates of cleavage and development for sheep zygotes cultured to the blastocyst stage in vitro in the absence of serum and somatic cells: Amino acids, vitamins, and culturing embryos in groups stimulate development. Biol Reprod 1994; 50(2):390–400.

    PubMed  CAS  Google Scholar 

  96. Harvey MB, Kaye PL. Insulin increases the cell number of the inner cell mass and stimulates morphological development of mouse blastocysts in vitro. Development 1990; 110(3):963–967.

    PubMed  CAS  Google Scholar 

  97. Gardner HG, Kaye PL. Insulin increases cell numbers and morphological development in mouse preimplantation embryos in vitro. Reprod Fertil Dev 1991; 3(1):79–91.

    PubMed  CAS  Google Scholar 

  98. Wood SA, Kaye PL. Effects of epidermal growth factor on preimplantation mouse embryos. J Reprod Fertil 1989; 85(2):575–582.

    PubMed  CAS  Google Scholar 

  99. Paria BC, Dey SK. Preimplantation embryo development in vitro: Cooperative interactions among embryos and role of growth factors. Proc Natl Acad Sci USA 1990

    Google Scholar 

  100. Pampfer S, Arceci RJ, Pollard JW. Role of colony stimulating factor-1 (CSF-1) and other lympho-hematopoietic growth factors in mouse preimplantation development. Bioessays 1991; 13(10):535–540.

    PubMed  CAS  Google Scholar 

  101. Larson RC, Ignotz GG, Currie WB. Platelet derived growth factor (PDGF) stimulates development of bovine embryos during the fourth cell cycle. Development 1992; 115(3):821–826.

    PubMed  CAS  Google Scholar 

  102. Lavranos TC, Rathjen PD, Seamark RF. Trophic effects of myeloid leukaemia inhibitory factor (LIF) on mouse embryos. J Reprod Fertil 1995; 105(2):331–338.

    PubMed  CAS  Google Scholar 

  103. Dunglison GF, Barlow DH, Sargent IL. Leukaemia inhibitory factor significantly enhances the blastocyst formation rates of human embryos cultured in serum-free medium. Hum Reprod 1996; 11(1):191–196.

    PubMed  CAS  Google Scholar 

  104. Jurisicova A, Ben-Chetrit A, Varmuza SL et al. Recombinant human leukemia inhibitory factor does not enhance in vitro human blastocyst formation. Fertil Steril 1995; 64(5):999–1002.

    PubMed  CAS  Google Scholar 

  105. Laird SM, Tuckerman EM, Dalton CF et al. The production of leukaemia inhibitory factor by human endometrium: Presence in uterine flushings and production by cells in culture. Hum Reprod 1997; 12(3):569–574.

    PubMed  CAS  Google Scholar 

  106. Mikolajczyk M, Skrzypczak J, Szymanowski K et al. The assessment of LIF in uterine flushing—a possible new diagnostic tool in states of impaired fertility. Reprod Biol 2003; 3(3):259–270.

    PubMed  Google Scholar 

  107. Olivennes F, Ledee-Bataille N, Samama M et al. Assessment of leukemia inhibitory factor levels by uterine flushing at the time of egg retrieval does not adversely affect pregnancy rates with in vitro fertilization. Fertil Steril 2003; 79(4):900–904.

    PubMed  Google Scholar 

  108. Hambartsoumian E. Endometrial leukemia inhibitory factor (LIF) as a possible cause of unexplained infertility and multiple failures of implantation. Am J Reprod Immunol 1998; 39(2):137–143.

    PubMed  CAS  Google Scholar 

  109. Steck T, Giess R, Suetterlin MW et al. Leukaemia inhibitory factor (LIF) gene mutations in women with unexplained infertility and recurrent failure of implantation after IVF and embryo transfer. Eur J Obstet Gynecol Reprod Biol 2004; 112(1):69–73.

    PubMed  CAS  Google Scholar 

  110. Danielsson KG, Swahn ML, Bygdeman M. The effect of various doses of mifepristone on endometrial leukaemia inhibitory factor expression in the midluteal phase-an immunohistochemical study. Human Reprod 1997; 12(6):1293–1297.

    CAS  Google Scholar 

  111. Hambartsoumian E. Human endometrial leukemia inhibitor factor (LIF) secretion and its relationship to sonographic endometrial appearance. Am J Reprod Immunol 1997; 37:320–325.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, Istanbul University Cerrahpasa School of Medicine, Istanbul, Turkey

    Levent M. Senturk

  2. Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut, USA

    Aydin Arid

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  1. Levent M. Senturk
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  1. Department of Obstetrics and Gynecology, Reproductive Immunology Unit, Yale University School of Medicine, New Haven, Connecticut, USA

    Gil Mor M.D., Ph.D.

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Senturk, L.M., Arid, A. (2006). Leukemia Inhibitory Factor in Reproduction. In: Mor, G. (eds) Immunology of Pregnancy. Medical Intelligence Unit. Springer, New York, NY. https://doi.org/10.1007/0-387-34944-8_11

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