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Autologous Mononuclear Bone Marrow Cell Transplantion for Myocardial Infarction: The German Experience

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Stem Cell Therapy and Tissue Engineering for Cardiovascular Repair

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8. References

  1. American Heart Association. Heart and Stroke Statistical Update. Dallas, Tex: American Heart Association 2001.

    Google Scholar 

  2. Ho KK, Anderson KM, Kannel WB, Grossman W, Levy D. Survival after the onset of congestive heart failure in Framingham Heart Study subjects. Circulation 1993; 88:107–115.

    Google Scholar 

  3. Heyndrickx GR, Baig H, Nellens P, Leusen I, Fishbein MC, Vatner SF. Depression of regional blood flow and wall thickening after brief coronary occlusions. Am J Physiol 1978; 234:H653–H659.

    Google Scholar 

  4. Reimer KA, Lowe JE, Rasmussen MM, Jennings RB. The wavefront phenomenon of ischemic cell death. 1. Myocardial infarct size vs duration of coronary occlusion in dogs. Circulation 1977; 56:786–794.

    Google Scholar 

  5. Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation 1986; 74:1124–1136.

    Google Scholar 

  6. Pfeffer MA. Left ventricular remodeling after acute myocardial infarction. Annu Rev Med 1995; 46:455–466.

    Google Scholar 

  7. Ryan TJ, Antman EM, Brooks NH, Califf RM, Hillis LD, Hiratzka LF et al. 1999 update: ACC/AHA guidelines for the management of patients with acute myocardial infarction. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Management of Acute Myocardial Infarction). J Am Coll Cardiol 1999; 34:890–911.

    Article  Google Scholar 

  8. Schwarz F, Schuler G, Katus H, Hofmann M, Manthey J, Tillmanns H et al. Intracoronary thrombolysis in acute myocardial infarction: duration of ischemia as a major determinant of late results after recanalization. Am J Cardiol 1982; 50:933–937.

    Google Scholar 

  9. Pfeffer MA, Braunwald E. Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications. Circulation 1990; 81:1161–1172.

    Google Scholar 

  10. Blau HM, Brazelton TR, Weimann JM. The evolving concept of a stem cell: entity or function? Cell 2001; 105:829–841.

    Article  Google Scholar 

  11. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999; 284:143–147.

    Article  Google Scholar 

  12. Graf T. Differentiation plasticity of hematopoietic cells. Blood 2002; 99:3089–3101.

    Article  Google Scholar 

  13. Reyes M, Lund T, Lenvik T, Aguiar D, Koodie L, Verfaillie CM. Purification and ex vivo expansion of postnatal human marrow mesodermal progenitor cells. Blood 2001; 98:2615–2625.

    Article  Google Scholar 

  14. Strauer BE, Kornowski R. Stem cell therapy in perspective. Circulation 2003; 107:929–934.

    Article  Google Scholar 

  15. Orlic D, Kajstura J, Chimenti S, Jakoniuk I, Anderson SM, Li B et al. Bone marrow cells regenerate infarcted myocardium. Nature 2001; 410:701–705.

    Article  Google Scholar 

  16. Kocher AA, Schuster MD, Szabolcs MJ, Takuma S, Burkhoff D, Wang J et al. Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function. Nat Med 2001; 7:430–436.

    Article  Google Scholar 

  17. Kawamoto A, Gwon HC, Iwaguro H, Yamaguchi JI, Uchida S, Masuda H et al. Therapeutic potential of ex vivo expanded endothelial progenitor cells for myocardial ischemia. Circulation 2001; 103:634–637.

    Google Scholar 

  18. Fuchs S, Baffour R, Zhou YF, Shou M, Pierre A, Tio FO et al. Transendocardial delivery of autologous bone marrow enhances collateral perfusion and regional function in pigs with chronic experimental myocardial ischemia. J Am Coll Cardiol 2001; 37:1726–1732.

    Article  Google Scholar 

  19. Asahara T, Masuda H, Takahashi T, Kalka C, Pastore C, Silver M et al. Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization. Circ Res 1999; 85: 221–228.

    Google Scholar 

  20. Orlic D, Kajstura J, Chimenti S, Limana F, Jakoniuk I, Quaini F et al. Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proc Natl Acad Sci U S A 2001; 98:10344–10349.

    Article  Google Scholar 

  21. Olivetti G, Quaini F, Sala R, Lagrasta C, Corradi D, Bonacina E et al. Acute myocardial infarction in humans is associated with activation of programmed myocyte cell death in the surviving portion of the heart. J Mol Cell Cardiol 1996; 28:2005–2016.

    Google Scholar 

  22. Li F, Wang X, Bunger PC, Gerdes AM. Formation of binucleated cardiac myocytes in rat heart: I. Role of actin-myosin contractile ring. J Mol Cell Cardiol 1997; 29:1541–1551.

    Google Scholar 

  23. Kajstura J, Leri A, Finato N, Di Loreto C, Beltrami CA, Anversa P. Myocyte proliferation in end-stage cardiac failure in humans. Proc Natl Acad Sci U S A 1998; 95:8801–8805.

    Article  Google Scholar 

  24. Soonpaa MH, Field LJ. Survey of studies examining mammalian cardiomyocyte DNA synthesis. Circ Res 1998; 83:15–26.

    Google Scholar 

  25. Grounds MD, White JD, Rosenthal N, Bogoyevitch MA. The role of stem cells in skeletal and cardiac muscle repair. J Histochem Cytochem 2002; 50:589–610.

    Google Scholar 

  26. Adler CP, Friedburg H, Herget GW, Neuburger M, Schwalb H. Variability of cardiomyocyte DNA content, ploidy level and nuclear number in mammalian hearts. Virchows Arch 1996; 429:159–164.

    Article  Google Scholar 

  27. Sun Y, Weber KT. Infarct scar: a dynamic tissue. Cardiovasc Res 2000; 46:250–256.

    Article  Google Scholar 

  28. Buschmann I, Schaper W. The pathophysiology of the collateral circulation (arteriogenesis). J Pathol 2000; 190:338–342.

    Article  Google Scholar 

  29. Beltrami AP, Urbanek K, Kajstura J, Yan SM, Finato N, Bussani R et al. Evidence that human cardiac myocytes divide after myocardial infarction. N Engl J Med 2001; 344:1750–1757.

    Article  Google Scholar 

  30. Jackson KA, Majka SM, Wang H, Pocius J, Hartley CJ, Majesky MW et al. Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells. J Clin Invest 2001; 107:1395–1402.

    Google Scholar 

  31. Quaini F, Urbanek K, Beltrami AP, Finato N, Beltrami CA, Nadal-Ginard B et al. Chimerism of the transplanted heart. N Engl J Med 2002; 346:5–15.

    Article  Google Scholar 

  32. Laflamme MA, Myerson D, Saffitz JE, Murry CE. Evidence for cardiomyocyte repopulation by extracardiac progenitors in transplanted human hearts. Circ Res 2002; 90:634–640.

    Article  Google Scholar 

  33. Rosenthal N. High hopes for the heart. N Engl J Med 2001; 344:1785–1787.

    Article  Google Scholar 

  34. Goodell MA, Jackson KA, Majka SM, Mi T, Wang H, Pocius J et al. Stem cell plasticity in muscle and bone marrow. Ann N Y Acad Sci 2001; 938:208–218.

    Google Scholar 

  35. Strauer BE, Brehm M, Zeus T, Gattermann N, Hernandez A, Sorg RV et al. [Intracoronary, human autologous stem cell transplantation for myocardial regeneration following myocardial infarction]. Dtsch Med Wochenschr 2001; 126:932–938.

    Article  Google Scholar 

  36. Kornowski R, Fuchs S, Leon MB, Epstein SE. Delivery strategies to achieve therapeutic myocardial angiogenesis. Circulation 2000; 101:454–458.

    Google Scholar 

  37. Tse HF, Kwong YL, Chan JK, Lo G, Ho CL, Lau CP. Angiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantation. Lancet 2003; 361:47–49.

    Article  Google Scholar 

  38. Perin EC, Dohmann HF, Borojevic R, Silva SA, Sousa AL, Mesquita CT et al. Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failure. Circulation 2003; 107:2294–2302.

    Google Scholar 

  39. Fuchs S, Satler LF, Kornowski R, Okubagzi P, Weisz G, Baffour R et al. Catheter-based autologous bone marrow myocardial injection in no-option patients with advanced coronary artery disease. A feasibility study. J Am Coll Cardiol 2003; 41:1721–1724.

    Google Scholar 

  40. Losordo DW, Vale PR, Hendel RC, Milliken CE, Fortuin FD, Cummings N et al. Phase 1/2 placebo-controlled, double-blind, dose-escalating trial of myocardial vascular endothelial growth factor 2 gene transfer by catheter delivery in patients with chronic myocardial ischemia. Circulation 2002; 105:2012–2018.

    Google Scholar 

  41. Toma C, Pittenger MF, Cahill KS, Byrne BJ, Kessler PD. Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart. Circulation 2002; 105:93–98.

    Article  Google Scholar 

  42. Aicher A, Brenner W, Zuhayra M, Badorff C, Massoudi S, Assmus B et al. Assessment of the tissue distribution of transplanted human endothelial progenitor cells by radioactive labeling. Circulation 2003; 107:2134–2139.

    Google Scholar 

  43. Menasche P, Hagege AA, Scorsin M, Pouzet B, Desnos M, Duboc D et al. Myoblast transplantation for heart failure. Lancet 2001; 357:279–280.

    Article  Google Scholar 

  44. Hamano K, Nishida M, Hirata K, Mikamo A, Li TS, Harada M et al. Local implantation of autologous bone marrow cells for therapeutic angiogenesis in patients with ischemic heart disease: clinical trial and preliminary results. Jpn Circ J 2001; 65:845–847.

    Google Scholar 

  45. Garot JJ, Unterseeh T, Teiger E, Champagne S, Chazaud BB, Gherardi R et al. Magnetic resonance imaging of targeted catheter-based implantation of myogenic precursor cells into infarcted left ventricular myocardium. J Am Coll Cardiol 2003; 41:1841–1846.

    Article  Google Scholar 

  46. Orlic D, Hill JM, Arai AE. Stem cells for myocardial regeneration. Circ Res 2002; 91:1092–1102.

    Article  Google Scholar 

  47. Zhao M, Beauregard DA, Loizou L, Davletov B, Brindle KM. Non-invasive detection of apoptosis using magnetic resonance imaging and a targeted contrast agent. Nat Med 2001; 7:1241–1244.

    Article  Google Scholar 

  48. Lederman RJ, Guttman MA, Peters DC, Thompson RB, Sorger JM, Dick AJ et al. Catheter-based endomyocardial injection with real-time magnetic resonance imaging. Circulation 2002; 105:1282–1284.

    Google Scholar 

  49. Hagege AA, Carrion C, Menasche P, Vilquin JT, Duboc D, Marolleau JP et al. Viability and differentiation of autologous skeletal myoblast grafts in ischaemic cardiomyopathy. Lancet 2003; 361:491–492.

    Article  Google Scholar 

  50. Theise ND, Nimmakayalu M, Gardner R, Illei PB, Morgan G, Teperman L et al. Liver from bone marrow in humans. Hepatology 2000; 32:11–16.

    Google Scholar 

  51. Korbling M, Katz RL, Khanna A, Ruifrok AC, Rondon G, Albitar M et al. Hepatocytes and epithelial cells of donor origin in recipients of peripheral-blood stem cells. N Engl J Med 2002; 346:738–746.

    Article  Google Scholar 

  52. Muller P, Pfeiffer P, Koglin J, Schafers HJ, Seeland U, Janzen I et al. Cardiomyocytes of noncardiac origin in myocardial biopsies of human transplanted hearts. Circulation 2002; 106:31–35.

    Article  Google Scholar 

  53. Thiele J, Varus E, Wickenhauser C, Kvasnicka HM, Metz K, Schaefer UW et al. [Chimerism of cardiomyocytes and endothelial cells after allogeneic bone marrow transplantation in chronic myeloid leukemia An autopsy study]. Pathologe 2002; 23:405–410.

    Google Scholar 

  54. Strauer BE, Brehm M, Zeus T, Kostering M, Hernandez A, Sorg RV et al. Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans. Circulation 2002; 106:1913–1918.

    Article  Google Scholar 

  55. Seiler C, Pohl T, Wustmann K, Hutter D, Nicolet PA, Windecker S et al. Promotion of collateral growth by granulocyte-macrophage colony-stimulating factor in patients with coronary artery disease: a randomized, double-blind, placebo-controlled study. Circulation 2001; 104:2012–2017.

    Google Scholar 

  56. Stamm C, Westphal B, Kleine HD, Petzsch M, Kittner C, Klinge H et al. Autologous bone-marrow stem-cell transplantation for myocardial regeneration. Lancet 2003; 361:45–46.

    Article  Google Scholar 

  57. Lee M, Lill M, Makkar R. Stem cell transplantation in myocardial infarction. Rev Cardiovasc Med. 2004; 5(2): 82–98.

    Google Scholar 

  58. Mathur A, Martin JF. Stem cells and the repair of the heart. Lancet 2004; 364:183–192.

    Article  Google Scholar 

  59. Pittenger MF, Martin BJ. Mesenchymal stem cells and their potential as cardiac therapeutics. Circulation Res. 2004; 95:9–20.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Dept. of Internal Medicine, Div. of Cardiology, Pneumology and Angiology, Heinrich-Heine-University, Moorestr. 5, 40225, Düsseldorf, Germany

    Michael Brehm & Bodo E. Strauer

  2. Heinrich Heine University, Düsseldorf, Germany

    Tobias Zeus M.D.

Authors
  1. Michael Brehm
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  2. Tobias Zeus M.D.
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  3. Bodo E. Strauer
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Editor information

Editors and Affiliations

  1. Arizona Heart Institute, 2632 North 20th Street, Phoenix, AZ, 85006, USA

    Nabil Dib MD, MSc, FACC (Director of Cardiovascular Research) & Edward B. Diethrich MD (Medical Director) (Director of Cardiovascular Research) &  (Medical Director)

  2. Center for Cardiovascular Repair, University of Minnesota, Minneapolis, MN, USA

    Doris A. Taylor PhD (Director) (Director)

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Brehm, M., Zeus, T., Strauer, B.E. (2006). Autologous Mononuclear Bone Marrow Cell Transplantion for Myocardial Infarction: The German Experience. In: Dib, N., Taylor, D.A., Diethrich, E.B. (eds) Stem Cell Therapy and Tissue Engineering for Cardiovascular Repair. Springer, Boston, MA. https://doi.org/10.1007/0-387-30939-X_11

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  • DOI: https://doi.org/10.1007/0-387-30939-X_11

  • Publisher Name: Springer, Boston, MA

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