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Adjuvants in EAE

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Experimental Models of Multiple Sclerosis

Abstract

Adjuvants enhance autoantigens’ immunogenicity and play a major role in the induction of EAE. Complete Freund’s adjuvant (CFA) is the key adjuvant for cell-mediated immunity, including EAE. An additional adjuvant, pertussis toxin, is necessary for active EAE in mice. The mechanisms of action of adjuvants are multiple, but important actions are stimulation of proinflammatory cytokines and costimulatory molecules.

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Author information

Authors and Affiliations

  1. Division of Clinical Neurology, University of Nottingham, UK

    Cris S Constantinescu & Brendan A Hilliard

  2. Depertment of Molecular and Celluar Engineering, University of Pennsylvania, Philadelphia, USA

    Cris S Constantinescu & Brendan A Hilliard

Authors
  1. Cris S Constantinescu
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  2. Brendan A Hilliard
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Editor information

Editors and Affiliations

  1. Weill Medical College of Cornell University, New York

    Ehud Lavi

  2. Queen’s Medical Centre, University Hospital, Nottingham, UK

    Cris S. Constantinescu

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Constantinescu, C.S., Hilliard, B.A. (2005). Adjuvants in EAE. In: Lavi, E., Constantinescu, C.S. (eds) Experimental Models of Multiple Sclerosis. Springer, Boston, MA. https://doi.org/10.1007/0-387-25518-4_5

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