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Traumatic Brain Injury: Laboratory Studies

  • Chapter
Therapeutic Hypothermia

Part of the book series: Molecular and Cellular Biology of Critical Care Medicine ((MCCM,volume 4))

Abstract

This chapter will address the use of therapeutic hypothermia in traumatic brain injury (TBI). Hypothermia has a long-standing history of clinical use in the management of patients with severe TBI, specifically as a second tier therapy in the treatment of refractory intracranial hypertension. The resurgence in the interest in the use of mild and moderate hypothermia in experimental cerebral ischemia and cardiac arrest in the late 1980s and early 1990s (culminating in its recent successful translation to clinical use for cardiac arrest) prompted parallel investigation in TBI beginning in 1991. This chapter will focus on that work—specifically, both laboratory and clinical investigation in the use of therapeutic hypothermia in TBI since 1991.

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Authors and Affiliations

  1. Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA, USA

    Patrick M. Kochanek MD, Larry W. Jenkins PhD & Robert S. B. Clark MD

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  1. Patrick M. Kochanek MD
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  2. Larry W. Jenkins PhD
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Editors and Affiliations

  1. Department of Critical Care, University of Pittsburgh, Pittsburgh, PA, 15213, USA

    Samuel A. Tisherman MD

  2. Emergency Medicine, Medical University of Vienna, 1090, Vienna, Austria

    Fritz Sterz MD

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Kochanek, P.M., Jenkins, L.W., Clark, R.S.B. (2005). Traumatic Brain Injury: Laboratory Studies. In: Tisherman, S.A., Sterz, F. (eds) Therapeutic Hypothermia. Molecular and Cellular Biology of Critical Care Medicine, vol 4. Springer, Boston, MA. https://doi.org/10.1007/0-387-25403-X_5

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