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Types of Status Epilepticus

Definitions and Classification

  • Chapter
Status Epilepticus

Part of the book series: Current Clinical Neurology ((CCNEU))

Abstract

What is status epilepticus? For all the criticisms leveled at the now-traditional definition accepted by the International League Against Epilepsy (ILAE) and based on the 1962 Marseilles conference, “a condition characterized by an epileptic seizure which is so frequently repeated or so prolonged as to create a fixed and lasting epileptic condition” (1), this definition does capture the concepts nearly everyone wants. The condition is necessarily epileptic, i.e., related to abnormal electrical activity in the brain with a clinical, and unhealthy, alteration in neurologic function. The patient in status epilepticus (SE) is clearly in a different and worse state than one who has an individual epileptic seizure only. Shorvon notes that SE is “not simply an iterative version of ordinary epilepsy” (2). Whether it is a more serious and fulminant etiology of seizures that produces their prolongation and repetition, or whether there is a fundamentally different failure of inhibition (more than occurs between a spike and a clinical seizure), the patient in status epilepticus has entered a new and worse condition. Discrete epileptic seizures come to an end, although there may be a prolonged postictal state. In SE, however, there is a definite clinical imperative to interrupt seizures because the patient may suffer grievous harm otherwise. Not only are there extensive physiologic, and sometimes pathologic, changes occurring during SE (3), but there is also a fundamentally different and urgent clinical problem for the patient and physician.

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References

  1. Gastaut H. Classification of status epilepticus. In: Delgado-Escueta AV, Wasterlain CG, Treiman DT, Porter RJ, eds. Status Epilepticus (vol. 34 in Advances in Neurology) New York: Raven Press; 1983:15–35.

    Google Scholar 

  2. Shorvon S. The concept of status epilepticus and its history. In: Shorvon S, ed. Status epilepticus: Its Clinical Features and Treatment in Children and Adults. Cambridge: Cambridge University Press; 1994:1–20.

    Google Scholar 

  3. Lothman E. The biochemical basis and pathophysiology of status epilepticus. Neurology 1990;40(suppl 2):13–23.

    PubMed  CAS  Google Scholar 

  4. DeLorenzo RJ, Hauser WA, Towne AR, Boggs JG, Pellock JM, Penberthy L, Garnett L, Fortner CA, Ko D. A prospective, population-based epidemiologic study of status epilepticus in Richmond, Virginia. Neurology 1996;46:1029–1035.

    PubMed  CAS  Google Scholar 

  5. Meldrum BS, Brierley JB. Prolonged epileptic seizures in primates. Ischemic cell change and its relation to ictal physiological events. Arch Neurol 1973;28:10–17.

    PubMed  CAS  Google Scholar 

  6. Meldrum BS, Horton RW. Physiology of status epilepticus in primates. Arch Neurol 1973;28:1–9.

    PubMed  CAS  Google Scholar 

  7. Meldrum BS, Vigouroux RA, Brierley JB. Systemic factors and epileptic brain damage. Arch Neurol 1973;29:82–87.

    PubMed  CAS  Google Scholar 

  8. Treiman DM, Meyers PD, Walton NY, Collins JF, Colling C, Rowan AJ, Handforth A, Faught E, Calabrese VP, Uthman BM, Ramsay RE, Mamdani MB. A comparison of four treatments for generalized convulsive status epilepticus. N Engl J Med 1998;339:792–798.

    Article  PubMed  CAS  Google Scholar 

  9. Alldredge BK, Gelb AM, Isaacs SM, Corry MD, Allen F, Ulrich SK, Gottwald MD, O’Neil N, Neuhaus JM, Segal MR, Lowenstein DH. A comparison of lorazepam, diazepam, and placebo for the treatment of out-of-hospital status epilepticus. N Engl J Med 2 2001;345:631–637.

    Article  CAS  Google Scholar 

  10. Lowenstein DH, Bleck T, Macdonald RL. It’s time to revise the definition of status epilepticus. Epilepsia 1999;40:120–122.

    Article  PubMed  CAS  Google Scholar 

  11. Theodore WH, Porter RJ, Albert P, Kelley K, Bromfield E, Devinsky O, Sato S. The secondarily generalized tonic-clonic seizure: a videotape analysis. Neurology 1994;44:1403–1407.

    PubMed  CAS  Google Scholar 

  12. DeLorenzo RJ, Garnett LK, Towne AR, Waterhouse EJ, Boggs JG, Morton L, Choudhry MA, Barnes T, Ko D. Comparison of status epilepticus with prolonged seizure episodes lasting from 10 to 29 minutes. Epilepsia 1999;40:164–169.

    Article  PubMed  CAS  Google Scholar 

  13. Shinnar S, Berg AT, Moshe SL, Shinnar R. How long do new-onset seizures in children last? Ann Neurol 2001;49;659–664.

    Article  PubMed  CAS  Google Scholar 

  14. Dennis LJ, Claassen J, Hirsch LJ, Emerson RG, Connolly ES, Mayer SA. Nonconvulsive status epilepticus after subarachnoid hemorrhage. Neurosurgery 2002;51:1136–1144.

    Article  PubMed  Google Scholar 

  15. Drislane FW, Blum AS, Schomer DL. Focal status epilepticus: clinical features and significance of different EEG patterns. Epilepsia 1999;40:1254–1260.

    Article  PubMed  CAS  Google Scholar 

  16. Waterhouse EJ, Garnett LK, Towne AR, Morton LD, Barnes T, Ko D, DeLorenzo RJ. Prospective population-based study of intermittent and continuous convulsive status epilepticus in Richmond, Virginia. Epilepsia 1999;40:752–758.

    Article  PubMed  CAS  Google Scholar 

  17. Nei M, Lee JM, Shanker VL, Sperling MR. The EEG and prognosis in status epilepticus. Epilepsia 1999;40:157–163.

    Article  PubMed  CAS  Google Scholar 

  18. Granner MA, Lee SI. Nonconvulsive status epilepticus: EEG analysis in a large series. Epilepsia 1994;35:42–47.

    Article  PubMed  CAS  Google Scholar 

  19. Treiman DM, Walton NY, Kendrick C. A progressive sequence of electrographic changes during generalized convulsive status epilepticus. Epilepsy Res 1990;5:49–60.

    Article  PubMed  CAS  Google Scholar 

  20. Handforth A, Cheng JT, Mandelkern MA, Treiman DM. Markedly increased mesiotemporal lobe metabolism in a case with PLEDs: further evidence that PLEDs are a manifestation of partial status epilepticus. Epilepsia 1994;35:876–881.

    Article  PubMed  CAS  Google Scholar 

  21. Brenner RP. Is it status? Epilepsia 2002;43(suppl 3):103–113.

    Article  PubMed  Google Scholar 

  22. Drislane FW, Schomer DL. Clinical implications of generalized electrographic status epilepticus. Epilepsy Res 1994;19:111–121.

    Article  PubMed  CAS  Google Scholar 

  23. DeLorenzo RJ, Waterhouse EJ, Towne AR, Boggs JG, Ko D, DeLorenzo GA, Brown A, Garnett L. Persistent nonconvulsive status epilepticus after the control of convulsive status epilepticus. Epilepsia 1998;39:833–840.

    Article  PubMed  CAS  Google Scholar 

  24. Vespa PM, Nuwer MR, Nenov V, Ronne-Engstrom E, Hovda DA, Bergsneider M, Kelly DF, Martin NA, Becker DP. Increased incidence and impact of nonconvulsive seizures after traumatic brain injury as detected by continuous electroencephalographic monitoring. J Neurosurg 1999;91:750–760.

    PubMed  CAS  Google Scholar 

  25. Towne AR, Waterhouse EJ, Boggs JG, Garnett LK, Brown AJ, Smith JR, DeLorenzo RJ, Smith JR Jr. Prevalence of nonconvulsive status epilepticus in comatose patients. Neurology 2000;54:340–345.

    PubMed  CAS  Google Scholar 

  26. Privitera M, Hoffman M, Moore JL, Jester D. EEG detection of nontonic-clonic status epilepticus in patients with altered consciousness. Epilepsy Res 1994;18:155–166.

    Article  PubMed  CAS  Google Scholar 

  27. So EL, Ruggles KH, Ahmann PA, Trudeau SK, Weatherford KJ, Trenerry MR. Clinical significance and outcome of subclinical status epilepticus in adults. J Epilepsy 1995;8:11–15.

    Article  Google Scholar 

  28. Lowenstein DH, Aminoff MJ. Clinical and EEG features of status epilepticus in comatose patients. Neurology 1992;42:100–104.

    PubMed  CAS  Google Scholar 

  29. Krishnamurthy KB, Drislane FW. Depth of electroencephalogram suppression and outcome in pentobarbital coma for refractory status epilepticus. Epilepsia 1999;40:759–762.

    Article  PubMed  CAS  Google Scholar 

  30. Claassen J, Hirsch LJ, Emerson RG, Bates JE, Thompson TB, Mayer SA. Continuous EEG monitoring and midazolam infusion for rerfractory nonconvulsive status epilepticus. Neurology 2001;57:1036–1042.

    PubMed  CAS  Google Scholar 

  31. Chatrian GE, Shaw CM, Leffman H. The significance of periodic lateralized epileptiform discharges in EEG: An electrographic, clinical and pathological study. Electroenceph Clin Neurophysiol 1964;17:177–193.

    Article  PubMed  CAS  Google Scholar 

  32. Schwartz MS, Prior PF, Scott DR. The occurrence and evolution in the EEG of a lateralized periodic phenomenon. Brain 1973;96:613–622.

    Article  PubMed  CAS  Google Scholar 

  33. Schraeder, PL, Singh N. Seizure disorders following periodic lateralized epileptiform discharges. Epilepsia 1980;21:647–653.

    PubMed  CAS  Google Scholar 

  34. Snodgrass SM, Tsuburaya K, Ajmone-Marsan C. Clinical significance of periodic lateralized epileptiform discharges: Relationship with status epilepticus. J Clin Neurophysiol 1989;6:159–172.

    Article  PubMed  CAS  Google Scholar 

  35. Walsh JM, Brenner RP. Periodic lateralized epileptiform discharges-long-term outcome in adults. Epilepsia 1987;28:533–536.

    PubMed  CAS  Google Scholar 

  36. Terzano MG, Parrino L, Mazzucchi A, Moretti G. Confusional states with periodic lateralized epileptiform discharges (PLEDs): a peculiar epileptic syndrome in the elderly. Epilepsia 1986;27:446–457.

    PubMed  CAS  Google Scholar 

  37. Garzon E, Fernandes RMF, Sakamoto AC. Serial EEG during human status epilepticus. Evidence for PLED as an ictal pattern. Neurology 2001;57:1175–1183.

    PubMed  CAS  Google Scholar 

  38. Fagan KJ, Lee SI. Prolonged confusion following convulsions due to generalized nonconvulsive status epilepticus. Neurology 1990;40:1689–1694.

    PubMed  CAS  Google Scholar 

  39. Kaplan PW. Nonconvulsive status epilepticus in the emergency room. Epilepsia 1996;37:643–650.

    Article  PubMed  CAS  Google Scholar 

  40. Martinez-Rodriquez JE, Barriga FJ, Santamaria J, Iranzo A, Pareja JA, Revilla M, de la Rosa CR. Nonconvulsive status epilepticus associated with cephalosporins in patients with renal failure. Am J Med 2001;111:115–119.

    Article  Google Scholar 

  41. Kaplan PW. Prognosis in nonconvulsive status epilepticus. In: Jallon P, ed. Prognosis of Epilepsies. Paris: John Libbey Eurotext; 2003:311–325.

    Google Scholar 

  42. Towne AR, Garnett LK, Waterhouse EJ, Morton LD, DeLorenzo RJ. The use of topiramate in refractory status epilepticus. Neurology 2003;60:332–334.

    PubMed  CAS  Google Scholar 

  43. Prasad A, Worrall BB, Bertram EH, Bleck TP. Propofol and midazolam in the treatment of refractory status epilepticus. Epilepsia 2001;42:380–386.

    Article  PubMed  CAS  Google Scholar 

  44. Bleck TB. Refractory status epilepticus in 2001 [editorial]. Arch Neurology 2002;59:188–189.

    Article  Google Scholar 

  45. Sahin M, Menache CC, Holmes GL, Riviello JJ. Outcome of severe refractory status epilepticus in children. Epilepsia 2001;42:1461–1467.

    Article  PubMed  CAS  Google Scholar 

  46. Jagoda A, Riggio S. Refractory status epilepticus in adults. Ann Emerg Med 1993;22:1337–1348.

    Article  PubMed  CAS  Google Scholar 

  47. Mayer SA, Claassen J, Lokin J, Mendelsohn F, Dennis LJ, Fitzsimmons BF. Refractory status epilepticus. Frequency, risk factors, and impact on outcome. Arch Neurol 2002;59:205–210.

    Article  PubMed  Google Scholar 

  48. Cascino GD, Hesdorffer D, Logroscino G, Hauser WA. Treatment of non-febrile status epilepticus in Rochester, Minn, from 1965 through 1984. Mayo Clin Proc 2001;76:39–41.

    PubMed  CAS  Google Scholar 

  49. Wolf P. Of cabbages and kings: some considerations on classifications, diagnostic schemes, semiology, and concepts. Epilepsia 2003;44:1–13.

    Article  PubMed  Google Scholar 

  50. Aminoff MJ, Simon RP. Status epilepticus: causes, clinical features, and consequences in 98 patients. Am J Med 1980;69:657–666.

    Article  PubMed  CAS  Google Scholar 

  51. DeLorenzo RJ. Clinical and epidemiologic study of status epilepticus in the elderly. In: Rowan AJ, Ramsay RE, eds. Seizures and Epilepsy in the Elderly. Boston: Butterworth-Heinemann; 1997:191–205.

    Google Scholar 

  52. Towne AR, Pellock JM, Ko D, DeLorenzo, RJ. Determinants of mortality in status epilepticus. Epilepsia 1994;35:27–34.

    Article  PubMed  CAS  Google Scholar 

  53. Lothman EW, Bertram EH, Bekenstein JW, Perlin JB. Self-sustaining limbic status epilepticus induced by “continuous” hippocampal stimulation: electrographic and behavioral characteristics. Epilepsy Res 1989;3:107–119.

    Article  PubMed  CAS  Google Scholar 

  54. van Landingham KE, Lothman EW. Self-sustaining limbic status epilepticus. I. Acute and chronic cerebral metabolic studies: limbic hypermetabolism and neocortical hypometabolism. Neurology 1991;41:1942–1949.

    Google Scholar 

  55. Shinnar S, Babb TL. Long-term sequelae of status epilepticus. In: Engel J, Pedley TA, eds. Epilepsy: A Comprehensive Textbook. Philadelphia: Lippincott-Raven; 1997:755–763.

    Google Scholar 

  56. Simon R, Pellock JM, DeLorenzo RJ. Acute morbidity and mortality of status epilepticus. In: Engel J, Pedley TA, eds. Epilepsy: A Comprehensive Textbook. Philadelphia: Lippincott-Raven; 1997:741–753.

    Google Scholar 

  57. Scholtes FB, Renier WO, Meinardi H. Simple partial status epilepticus: causes, treatment, and outcome in 47 patients. J Neurol Neurosurg Psychiatry 1996;61:90–92.

    PubMed  CAS  Google Scholar 

  58. Colamaria V, Sgro V, Caraballo R, Simeone M, Zullini E, Fontana E, Zanetti R, Grimau-Merino R, Dalla Bernardina B. Status epilepticus in benign Rolandic epilepsy manifesting as anterior operculum syndrome. Epilepsia 1991;32:329–334.

    PubMed  CAS  Google Scholar 

  59. Juul-Jensen P, Denny-Brown D. Epilepsia partialis continua. A clinical, electroencephalographic, and neuropathological study of nine cases. Arch Neurol 1966;15:563–578.

    PubMed  CAS  Google Scholar 

  60. Cockerell OC, Rothwell J, Thompson PD, Marsden CD, Shorvon SD. Clinical and physiological features of eplepsia partialis continua. Cases ascertained in the UK. Brain 1996;119:393–407.

    Article  PubMed  Google Scholar 

  61. Berkovic SF, Andermann F, Carpenter S, Wolfe LS. Progressive myoclonus epilepsies: specific causes and diagnosis. N Engl J Med 1986;315:296–305.

    Article  PubMed  CAS  Google Scholar 

  62. Young GB, Gilbert JJ, Zochodne DW. The significance of myoclonic status epilepticus in postanoxic coma. Neurology 1990;40:1843–1848.

    PubMed  CAS  Google Scholar 

  63. Celesia GG, Grigg MM, Ross E. Generalized status myoclonicus in acute anoxic and toxicmetabolic encephalopathies. Arch Neurol 1988;45:781–784.

    PubMed  CAS  Google Scholar 

  64. Tomson T, Lindbom U, Nilsson BY. Nonconvulsive status epilepticus in adults: thirty-two consecutive patients from a general hospital population. Epilepsia 1992;33:829–835.

    Article  PubMed  CAS  Google Scholar 

  65. Kaplan PW. Nonconvulsive status epilepticus. Semin Neurol 1996;16:33–40.

    Article  PubMed  CAS  Google Scholar 

  66. Schwab RS. A case of status epilepticus in petit mal. Electroenceph Clin Neurophysiol 1953;5:441–442.

    Article  PubMed  CAS  Google Scholar 

  67. Thomas P, Beaumanoir A, Genton P, Dolisi C, Chatel M. “De novo” absence status of late onset: report of 11 cases. Neurology 1992;42:104–110.

    PubMed  CAS  Google Scholar 

  68. Agathonikou A, Panayiotopoulos CP, Giannakodimos S, Koutroumanidis M. Typical absence status in adults: diagnostic and syndromic considerations. Epilepsia 1998;39:1265–1276.

    Article  PubMed  CAS  Google Scholar 

  69. Kanazawa O, Kawai I. Status epilepticus characterized by repetitive asymmetrical atonia: Two cases accompanied by partial seizures. Epilepsia 1990; 31:536–543.

    PubMed  CAS  Google Scholar 

  70. Lim J, Yagnik P, Schraeder P, Wheeler S. Ictal catatonia as a manifestation of nonconvulsive status epilepticus. J Neurol Neurosurg Psychiatry 1986;49:833–836.

    PubMed  CAS  Google Scholar 

  71. Thomas P, Borg M, Suisse G, Chatel M. Opercular myoclonic-anarthric status epilepticus. Epilepsia 1995;36:281–289.

    Article  PubMed  CAS  Google Scholar 

  72. Belafsky MA, Carwille S, Miller P, Waddell G, Boxley-Johnson J, Delgado-Escueta AV. Prolonged epileptic twilight states: continuous recordings with nasopharyngeal electrodes and videotape analysis. Neurology 1978;28:239–245.

    PubMed  CAS  Google Scholar 

  73. Engel J, Ludwig, BI, Fetell M. Prolonged partial complex status epilepticus: EEG and behavioral observations. Neurology 1978;28:863–869.

    PubMed  Google Scholar 

  74. Ballenger CE, King DW, Gallagher BB. Partial complex status epilepticus. Neurology 1983;33:1545–1552.

    PubMed  Google Scholar 

  75. Treiman DM, Delgado-Escueta AV. Complex partial status epilepticus. In: Delgado-Escueta AV, Wasterlain CG, Treiman DM, Porter RJ, eds. Status Epilepticus. (Advances in Neurology; vol. 34) New York: Raven Press; 1983:69–81.

    Google Scholar 

  76. Cockerell OC, Walker MC, Sander JWAS, Shorvon SD. Complex partial status epilepticus: a recurrent problem. J Neurol Neurosurg Psychiatry 1994;57:835–837.

    PubMed  CAS  Google Scholar 

  77. Kaplan PW. Behavioral manifestations of nonconvulsive status epilepticus. Epilepsy Behav 2002;3:122–139.

    Article  PubMed  Google Scholar 

  78. Mayeux R, Lueders H. Complex partial status epilepticus: case report and proposal for diagnostic criteria. Neurology 1978;28:957–961.

    PubMed  CAS  Google Scholar 

  79. Patry G, Lyagoubi S, Tassinari A. Subclinical “electrical status epilepticus” induced by sleep in children. A clinical and electroencephalographic study of six cases. Arch Neurol 1971; 24:242–252.

    PubMed  CAS  Google Scholar 

  80. Tassinari CA, Bureau M, Dravet C, Dalla Bernardina B, Roger J. Epilepsy with continuous spikes and waves during slow sleep-otherwise described as ESES (epilepsy with electrical status epilepticus during slow sleep). In: Roger J, Bureau M, Dravet C, Dreifuss FE, Perret A, Wolf P, eds. Epileptic Syndromes in Infancy, Childhood, and Adolescence. 2nd ed. London: John Libbey and Co.; 1992:245–256.

    Google Scholar 

  81. Landau W, Kleffner FR. Syndrome of acquired aphasia with convulsive disorder in children. Neurology 1957;7:523–530.

    PubMed  CAS  Google Scholar 

  82. Bishop DVM. Age of onset and outcome in acquired aphasia with convulsive disorder (Landau-Kleffner syndrome). Dev Med Child Neurol 1985;27:705–712.

    Article  PubMed  CAS  Google Scholar 

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Drislane, F.W. (2005). Types of Status Epilepticus. In: Drislane, F.W. (eds) Status Epilepticus. Current Clinical Neurology. Humana Press. https://doi.org/10.1385/1-59259-945-1:011

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