Skip to main content
SpringerLink
Log in

Depression and Antidepressant-Associated Erectile Dysfunction

  • Chapter
Oral Pharmacotherapy for Male Sexual Dysfunction

Part of the book series: Current Clinical Urology ((CCU))

  • 567 Accesses

Abstract

Erectile dysfunction (ED) is a highly prevalent disorder in aging men, with multiple associated risk factors and comorbidities (1–4).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 159.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Rosen R, Fisher W, Eardley I, Niederber C, Nadel A, Sand M. (2004) The multinational men’s attitudes of life events and sexuality (MALES) study: prevalence of erectile dysfunction and related health concerns in the general population. Curr Med Res Opin 20:607–617.

    Article  PubMed  Google Scholar 

  2. Braun M, Wassmer G, Klotz T, Reifenrath B, Mathers M, Engelmann U. (2000) Epidemiology of erectile dysfunction: results of the ‘Cologne Male Survey.’ Int J Impot Res 12:305–311.

    Article  PubMed  CAS  Google Scholar 

  3. Mak R, De Backer G, Kornitzer M, De Meyer JM. (2002) Prevalence and correlates of erectile dysfunction in a population-based study in Belgium. Eur Urol 41:132–138.

    Article  PubMed  Google Scholar 

  4. Nicolosi A, Moreira ED, Shirai M, Ismail Bin Mohd Tambi M, Glasser DB. (2003) Epidemiology of erectile dysfunction in four countries: cross-national study of the prevalence and correlates of erectile dysfunction. Urology 61:201–206.

    Article  PubMed  Google Scholar 

  5. Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB. (1994) Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. J Urol 151:54–61.

    PubMed  CAS  Google Scholar 

  6. Araujo AB, Durante R, Feldman HA, et al. (1998) The relationship between depressive symptoms and male erectile dysfunction: cross-sectional results from the Massachusetts Male Aging Study. Psychosom Med 60:458–465.

    PubMed  CAS  Google Scholar 

  7. Laumann EO, Paik A, Rosen RC. (1999) Sexual dysfunction in the United States: prevalence and predictors. JAMA 281:537–544.

    Article  PubMed  CAS  Google Scholar 

  8. Mathew RJ, Weinman ML. (1982) Sexual dysfunctions in depression. Arch Sex Behav 11:323–328.

    Article  PubMed  CAS  Google Scholar 

  9. Margolese HC, Assalian P. (1996) Sexual side effects of antidepressants: a review. J Sex Marital Ther 22:209–217.

    PubMed  CAS  Google Scholar 

  10. Rosen R, Lane R, Menza M. (1999) Effects of SSRIs on sexual function: a critical review. J Clin Psychopharmacol 19:67–85.

    Article  PubMed  CAS  Google Scholar 

  11. Rosen R, Marin H. (2003) Prevalence of antidepressant-associated erectile dysfunction. J Clin Psych 64:5–10.

    Google Scholar 

  12. Roose SP, Glassman AH, Walsh BT, et al. (1982) Reversible loss of nocturnal penile tumescence during depression: a preliminary report. Neuropsychobiology 8:284–288.

    PubMed  CAS  Google Scholar 

  13. Moreira ED Jr, Abdo CH, Torres EB, Lobo CF, Fittipaldi JA. (2001) Prevalence and correlates of erectile dysfunction: results of the Brazilian study of sexual behavior. Urology 58:583–588.

    Article  PubMed  Google Scholar 

  14. Kennedy SH, Dickens SE, Eisfeld BS, et al. (1999) Sexual dysfunction before antidepressant therapy in major depression. J Affect Disord 56:201–208.

    Article  PubMed  CAS  Google Scholar 

  15. Zajecka J, Dunner DL, Gelenberg A, et al. (2002) Sexual function and satisfaction in the treatment of chronic major depression with nefazodone, sychotherapy, and their combination. J Clin Psychiat 63:709–716.

    CAS  Google Scholar 

  16. Nurnberg HG, Hensley PL, Gelenberg AJ, et al. (2003) Treatment of antidepressant-associated sexual dysfunction with sildenafil: a randomized controlled trial. JAMA 289:56–64.

    Article  PubMed  CAS  Google Scholar 

  17. Ashton AK, Hamer R, Rosen RC. (1997) Serotonin reuptake inhibitor-induced sexual dysfunction and its treatment: a large-scale retrospective study of 596 psychiatric outpatients. J Sex Marital Ther 23:165–175.

    Google Scholar 

  18. Jacobsen FM. (1992) Fluoxetine-induced sexual dysfunction and an open trial of yohimbine. J Clin Psychiatry 53:119–122.

    PubMed  CAS  Google Scholar 

  19. Montejo-Gonzalez AL, Llorca G, Izquierdo JA, et al. (1997) SSRI-induced sexual dysfunction: fluoxetine, paroxetine, sertraline, and fluvoxamine in a prospective, multicenter, and descriptive clinical study of 344 patients. J Sex Marital Ther 23:176–194.

    PubMed  CAS  Google Scholar 

  20. Labbate LA, Grimes J, Hines A, et al. (1998) Sexual dysfunction induced by serotonin reuptake antidepressants. J Sex Marital Ther 24:3–12.

    PubMed  CAS  Google Scholar 

  21. Fava M, Amsterdam JD, Deltito JA, et al. (1998) A double-blind study of paroxetine, fluoxetine, and placebo in outpatients with major depression. Ann Clin Psychiatry 10:145–150.

    Article  PubMed  CAS  Google Scholar 

  22. Clayton AH, Pradko JF, Croft HA, et al. (2002) Prevalence of sexual dysfunction among newer antidepressants. J Clin Psychiatry 63:357–366.

    PubMed  Google Scholar 

  23. Haensel SM, Klem TM, Hop WC, et al. (1998) Fluoxetine and premature ejaculation: a double-blind, crossover, placebo-controlled study. J Clin Psychopharmacol 18:72–77.

    Article  PubMed  CAS  Google Scholar 

  24. Halaris A. (2003) Neurochemical aspects of the sexual response cycle. CNS Spectr 8:211–216.

    PubMed  Google Scholar 

  25. Segraves RT. (1989) Effects of psychotropic drugs on human erection and ejaculation. Arch Gen Psychiatry 46:275–284.

    PubMed  CAS  Google Scholar 

  26. Hyttel J.(1994) Pharmacological characterization of selective serotonin reuptake inhibitors (SSRIs). Int Clin Psychopharmacol 9(Suppl 1):19–26.

    Article  PubMed  Google Scholar 

  27. Kugaya A, Seneca NM, Snyder PJ, et al. (2003) Changes in human in vivo serotonin and dopamine transporter availabilities during chronic antidepressant administration. Neuropsychopharmacology 28:413–420.

    Article  PubMed  CAS  Google Scholar 

  28. Bitran D, Hull EM. (1987) Pharmacological analysis of male rat sexual behavior. Neurosci Biobehav Rev 11:365–389.

    Article  PubMed  CAS  Google Scholar 

  29. Sullivan G, Lukoff D. (1990) Sexual side effects of antipsychotic medication: evaluation and interventions. Hosp Community Psychiatry 41:1238–1341.

    PubMed  CAS  Google Scholar 

  30. Richelson E. (1994) The pharmacology of antidepressants at the synapse: focus on newer compounds. J Clin Psychiatry 55(Suppl A):34–39.

    PubMed  Google Scholar 

  31. Stanton T, Bolden-Watson C, Cusack B, et al. (1993) Antagonism of the five cloned human muscarinic cholinergic receptors expressed in CHO-K1 cells by antidepressants and antihistaminics. Biochem Pharmacol 45:2352–2354.

    Article  PubMed  CAS  Google Scholar 

  32. Davies PH. (1997) Drug-related hyperprolactinaemia. Adverse Drug React Toxicol Rev 16:83–94.

    PubMed  CAS  Google Scholar 

  33. Cowen PJ, Sargent PA. (1997) Changes in plasma prolactin during SSRI treatment: evidence for a delayed increase in 5-HT neurotransmission. J Psychopharmacol 11:345–348.

    PubMed  CAS  Google Scholar 

  34. Amsterdam JD, Garcia-Espana F, Goodman D, et al. (1997) Breast enlargement during chronic antidepressant therapy. J Affect Disord 46:151–156.

    Article  PubMed  CAS  Google Scholar 

  35. Finkel MS, Laghrissi-Thode F, Pollock BG, et al. (1996) Paroxetine is a novel nitric oxide synthase inhibitor. Psychopharmacol Bull 32:653–658.

    PubMed  CAS  Google Scholar 

  36. Seidman SN, Roose SP, Menza MA, et al. (2001) Treatment of erectile dysfunction in men with depressive symptoms: results of a placebo-controlled trial with sildenafil citrate. Am J Psychiatry 158:1623–1630.

    Article  PubMed  CAS  Google Scholar 

  37. Tignol JL, Benkert O. (2001) Sildenafil citrate effectively treats erectile dysfunction in men who have been successfully treated for depression. New Orleans, LA: American Psychiatric Association Annual Meeting, 2001.

    Google Scholar 

  38. Nurnberg HG, Hensley P, Lauriello J, et al. (2001) Sildenafil citrate for the treatment of sexual dysfunction associated with serotonergic reuptake inhibitors. Int J Impot Res 13:S49.

    Article  Google Scholar 

  39. Nurnberg HG, Gelenberg A, Hargreave TB, et al. (2001) Efficacy of sildenafil citrate for the treatment of erectile dysfunction in men taking serotonin reuptake inhibitors. Am J Psychiatry 158:1926–1928.

    Article  PubMed  CAS  Google Scholar 

  40. American Psychiatric Association. (2000) Practice guideline for the treatment of patients with major depressive disorder. Am J Psychiatry 157:1–45.

    Google Scholar 

  41. Greden JF. (2001) The burden of disease for treatment-resistant depression. J Clin Psychiatry 62:26–31.

    PubMed  Google Scholar 

  42. Slag MF, Morley JE, Elson MK, et al. (1983) Impotence in medical clinic outpatients. JAMA 249:1736–1740.

    Article  PubMed  CAS  Google Scholar 

  43. Benet AE, Melman A. (1995) The epidemiology of erectile dysfunction. Urol Clin North Am 22:699–709.

    PubMed  CAS  Google Scholar 

  44. Keene LC, Davies PH. (1999) Drug-related erectile dysfunction. Adverse Drug React Toxicol Rev 18:5–24.

    PubMed  CAS  Google Scholar 

  45. Katon W, von Korff M, Lin E, et al. (1992) Adequacy and duration of antidepressant treatment in primary care. Med Care 30:67–76.

    Article  PubMed  CAS  Google Scholar 

  46. Lin EH, Von Korff M, Katon W, et al. (1995) The role of the primary care physician in patients’adherence to antidepressant therapy. Med Care 33:67–74.

    Article  PubMed  CAS  Google Scholar 

  47. American Psychiatric Association. (1994) Diagnostic and Statistical Manual of Mental Disorders. Washington, DC: American Psychiatric Association.

    Google Scholar 

  48. Hamilton MA. (1960) A rating scale for depression. J Neurol Neurosurg Psychiatry 23:56–62.

    Article  PubMed  CAS  Google Scholar 

  49. Montgomery S, Asberg M. (1979) A new depression scale designed to be sensitive to change. Brit J Psychiatry 134:382–389.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Psychiatry, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ

    Raymond C. Rosen PhD

  2. Department of Medicine, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ

    Raymond C. Rosen PhD

Authors
  1. Raymond C. Rosen PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Urology, Mayo Clinic College of Medicine, Jacksonville, FL

    Gregory A. Broderick MD

Rights and permissions

Reprints and permissions

Copyright information

© 2005 Humana Press Inc., Totowa, NJ

About this chapter

Cite this chapter

Rosen, R.C. (2005). Depression and Antidepressant-Associated Erectile Dysfunction. In: Broderick, G.A. (eds) Oral Pharmacotherapy for Male Sexual Dysfunction. Current Clinical Urology. Humana Press. https://doi.org/10.1385/1-59259-871-4:237

Download citation

  • DOI: https://doi.org/10.1385/1-59259-871-4:237

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-451-7

  • Online ISBN: 978-1-59259-871-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation