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B-Cell Immunity in Multiple Sclerosis

  • Chapter
Multiple Sclerosis

Part of the book series: Current Clinical Neurology ((CCNEU))

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Abstract

Multiple sclerosis (MS) is the most common chronic neurological disorder in young Caucasian adults (1–3), but after more than a century of active research, its etiology remains unknown. It is a peculiar disease, because it is restricted to the central nervous system (CNS), is not associated with any other neurological or systemic disorder, and has no animal counterpart. In the typical form, MS evolves through relapses and remissions, although, in the majority of patients, a secondary progressive phase ensues (4–7). Its classic pathological hallmark is the plaque, which, in the acute form of the disease, shows perivascular infiltration and contains macrophages filled with myelin debris (8–16). This classic view is challenged by magnetic resonance imaging (MRI) and pathological studies, which reveal substantial early axonal damage.

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Authors and Affiliations

  1. Department of Neurology, University of California, Irvine, CA

    Yufen Qin MD

  2. Department of Neurology, Hospital Notré-Dame, University of Montreal, Montreal, Quebéc, Canada

    Pierre Duquette MD

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  1. Yufen Qin MD
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  2. Pierre Duquette MD
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  1. Multiple Sclerosis Center, Department of Neurology, University of California, Irvine, CA

    Michael J. Olek DO

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© 2005 Humana Press Inc., Totowa, NJ

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Qin, Y., Duquette, P. (2005). B-Cell Immunity in Multiple Sclerosis. In: Olek, M.J. (eds) Multiple Sclerosis. Current Clinical Neurology. Humana Press. https://doi.org/10.1385/1-59259-855-2:113

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  • DOI: https://doi.org/10.1385/1-59259-855-2:113

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