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Animal Models of Resuscitation

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Cardiopulmonary Resuscitation

Part of the book series: Contemporary Cardiology ((CONCARD))

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Abstract

The ultimate goal of cardiopulmonary resuscitation (CPR) is the total reanimation of the cardiac arrest (CA) victim back to their pre-arrest status. Much of what we know and do regarding human CPR is based on animal modeling of the many components of CA and its treatment. Ideally, hypotheses regarding mechanisms of injury caused by arrest and treatments to improve outcome should first be tested in robust preclinical models of this disease followed by clinical testing. Although some aspects of the disease and treatment lend themselves to computational, cell culture, and isolated organ modeling, whole animal experimentation remains the standard for preclinical testing (1–4). To this end, the proper design and use of the preclinical model is crucial to ensure that clinical trials are warranted and optimally designed for ultimate validation of the hypotheses.

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Authors and Affiliations

  1. Departments of Emergency Medicine and Physiology, VCU Reanimation Engineering Shock Center, Virginia Commonwealth University Medical Center, Richmond, VA

    Kevin R. Ward MD

  2. Department of Emergency Medicine and Physiology, VCU Reanimation Engineering Shock Center, Virginia Commonwealth University Medical Center, Richmond, VA

    R. Wayne Barbee PhD

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Editors and Affiliations

  1. Department of Emergency Medicine, Virginia Commonwealth University Health System, Richmond, VA

    Joseph P. Ornato MD, FACP, FACC, FACEP  & Mary Ann Peberdy MD, FACC  & 

  2. Department of Internal Medicine (Cardiology), Virginia Commonwealth University Health System, Richmond, VA

    Joseph P. Ornato MD, FACP, FACC, FACEP  & Mary Ann Peberdy MD, FACC  & 

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Ward, K.R., Barbee, R.W. (2005). Animal Models of Resuscitation. In: Ornato, J.P., Peberdy, M.A. (eds) Cardiopulmonary Resuscitation. Contemporary Cardiology. Humana Press. https://doi.org/10.1385/1-59259-814-5:683

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  • DOI: https://doi.org/10.1385/1-59259-814-5:683

  • Publisher Name: Humana Press

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