Abstract
This chapter introduces the concept of an island graft, in which large full-thickness skin wounds are created with a small treatment area in the center. The island graft is a simple method for demonstrating the effect of epithelial derivatives on wound regeneration without using sophisticated biologic or genetic markers. In the absence of disease, mammalian wounds of the dermis close by scarring and contraction. The island graft permits observation of the test material within the wound without interference from the periphery for several days until wound contraction and epithelialization of the surrounding skin encroach upon the study area.
Preview
Unable to display preview. Download preview PDF.
Author information
Authors and Affiliations
Corresponding author
Editor information
Rights and permissions
About this chapter
Cite this chapter
Orgill, D.P., Butler, C.E. Island Grafts: A Model for Studying Skin Regeneration in Isolation from other Processes. In: Yannas, I.V. (eds) Regenerative Medicine I. Advances in Biochemical Engineering, vol 93. Springer, Berlin, Heidelberg. https://doi.org/10.1007/b99970
Download citation
DOI: https://doi.org/10.1007/b99970
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-22871-4
Online ISBN: 978-3-540-31448-6
eBook Packages: Chemistry and Materials ScienceChemistry and Material Science (R0)