Abstract
Thus, four recent approaches to systematic synthesis analysis have been reviewed and their merits and drawbacks outlined. It seems certain that the use of computer programs to assist synthesis analysis will become routine within the next decade. If anything stands out from the entire discussion, it is that the introduction of computerized methods into the once sacrosanct field of classical synthesis analysis has made the long-predicted computer age of chemistry a reality.
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References and footnotes
Woodward, R. B.: Synthesis. In: Perspectives in organic chemistry, p. 155. New York, N. Y.: Interscience 1956.
Corey, E. J.: Pure Appl. Chem. 14, 19 (1967).
Corey, E. J., Wipke, W. T.: Science 166, 178 (1969).
Dr. Cattell has been Research Professor in Psychology and Director of the Laboratory of Personality Assessment at the University of Illinois for the last 25 years. The quotation is from his book: The scientific analysis of personality, p. 102. Penguin: 1967.
For a review see: Corey, E. J.: Quart. Rev. (London) 25, 455 (1971).
Corey, E. J., Wipke, W. T., Cramer, R. D., Howe, W. J.: J. Am. Chem. Soc. 94, 421 (1972).
Corey, E. J., Wipke, W. T., Cramer, R. D., Howe, W. J.: J. Am. Chem. Soc. 94, 431 (1972).
Corey, E. J., Cramer, R. D., Howe, W. J.: J. Am. Chem. Soc. 94, 440 (1972).
Corey, E. J., Petersson, G. A.: J. Am. Chem. Soc. 94, 460 (1972).
Woodward, R. B., von E. Doering, W.: J. Am. Chem. Soc. 67, 860 (1945).
Woodward, R. B., Bader, F. E., Bickel, H., Frey, A. J., Kierstead, R. W.: Tetrahedron 2, 1 (1958).
Gelernter, H., Sridharan, N. S., Hart, A. J., Fowler, F. W., Shue, H. J.: An application of artificial intelligence to the problem of organic synthesis discovery; Technical Report, Departments of Computer Science and Chemistry, State University of New York at Stony Brook, August 1971.
Amarel, S.: Problem solving and decision making by computer: An overview. In: Cognition and artificial intelligence: A multiple view (ed. Garvin). Aldine Press 1969.
Hendrickson, J. B.: J. Am. Chem. Soc. 93, 6847 (1971).
Hendrickson, J. B.: J. Am. Chem. Soc. 93, 6854 (1971).
The discovery of new methods for performing specific structural operations requires first a realization of certain unfilled needs in the field of synthesis. Quoted from Ref.2), p. 31. See Ref.2) for a review of such work.
See for example: Morgan, H. L.: J. Chem. Doc. 5, 107 (1965). For a review see Ref.3).
See the text: Ireland, R. E.: Organic synthesis for a representative example of currents methods of teaching synthetic planning. Prentice-Hall, N. Y. 1969.
Ugi, I., Gillespie, P.: Angew. Chem. Intern. Ed. Engl. 10, 915 (1971).
Ugi, I., Gillespie, P.: Angew. Chem. Intern. Ed. Engl. 10, 914 (1971).
Gillespie, P., Hoffmann, P., Klusacek, H., Marquarding, D., Pfohl, S., Ramirez, F. Tsolis, E. A., Ugi, I.: Angew. Chem. Intern. Ed. Engl. 10, 687 (1971).
Ugi, I., Marquarding, D., Klusacek, H., Gokel, G., Gillespie, P.: Angew. Chem. Intern. Ed. Engl. 9, 703 (1970).
Dugundji, J., Gillespie, P., Ugi, I., Marquarding, D.: The metric nature of chemistry. In: The chemical applications of graph theory (ed. A. Balaban). Academic Press to be published
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Thakkar, A.J. (1973). The coming of the computer age to organic chemistry: Recent approaches to systematic synthesis analysis. In: Computers in Chemistry. Fortschritte der Chemischen Forschung, vol 39/1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/BFb0051316
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DOI: https://doi.org/10.1007/BFb0051316
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