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Nanobiotechnology: Paving the Way to Personalized Medicine

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NanoBioMedicine

Abstract

Current medical treatments have been addressing the medical needs of patients for centuries. These drugs target various cellular surface receptors and intracellular moieties to exhibit their effects. The integration of the nanobiotechnology tools in pharmaceutical sciences has proved that the therapeutic effectiveness of the drug molecules and other bioactive molecules can be considerably increased. Moreover, the drug molecules can be targeted to the particular site of action causing a significant decrease in the appearance of the adverse drug reactions. The development in omics sciences has further supported the development of biotechnology as an efficient means to detect, diagnose, and treat various diseased conditions. Conversely, nanotechnology along with the developments in the fields of materials sciences, bioengineering, and systems biology has made it possible to view, model, fabricate, manipulate, and modify the anatomical, biochemical, and physiological patterns within a living cell and in turn tissue, organ, and, ultimately, an organism. The merger of the two sciences, nanotechnology and biotechnology, has given rise to nanobiotechnology which can serve as a means to attain the ultimate goal of the healthcare system by being predictive, preventive, personalized, and participatory. The current chapter reviews the interdisciplinary nature of the field of nanobiotechnology and the employment of its principles in the developing safe, stable, efficient, and cost-effective personalized treatment options.

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Abbreviations

ADRs:

adverse drug reactions

BBB:

blood-brain barrier

CNS:

central nervous system

DNA:

deoxyribonucleic acid

EPR:

enhanced permeation retention

FDA:

food and drug authority

LMW:

low molecular weight

NCs:

nano carriers

nm:

nanometer

PTMs:

post-translational modifications

RNA:

ribonucleic acid

TAA:

tumor-associated antigens

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Authors and Affiliations

  1. Shifa College of Pharmaceutical Sciences, Shifa Tameer-e-Millat University, Islamabad, Pakistan

    Qaneeta Haseeb, Syed Damin Abbas Hamdani, Aasma Akram, Duaa Ahmad Khan, Tausif Ahmed Rajput & Mustafeez Mujtaba Babar

  2. Government College University, Faisalabad, Pakistan

    Aasma Akram

Authors
  1. Qaneeta Haseeb
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  2. Syed Damin Abbas Hamdani
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  3. Aasma Akram
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  4. Duaa Ahmad Khan
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  5. Tausif Ahmed Rajput
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  6. Mustafeez Mujtaba Babar
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Editors and Affiliations

  1. Centre for Advanced Research, King George’s Medical University, Lucknow, India

    Shailendra K. Saxena

  2. Amity University of Biotechnology, Amity University Haryana, Gurgaon, India

    S. M. Paul Khurana

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Haseeb, Q., Hamdani, S.D.A., Akram, A., Khan, D.A., Rajput, T.A., Babar, M.M. (2020). Nanobiotechnology: Paving the Way to Personalized Medicine. In: Saxena, S., Khurana, S. (eds) NanoBioMedicine. Springer, Singapore. https://doi.org/10.1007/978-981-32-9898-9_2

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