Abstract
Candidal infections are increasing at an alarming pace resulting in increase in mortality and morbidity rates. They can cause life-threatening infections which can range from oral to systemic infections in immunocompromised patients. With concomitant emergence of multidrug resistance (MDR), there is an intense need to search for novel compounds as the current therapeutic regimes are limited by their toxicity concerns and cost-effectiveness. Natural sources represent an attractive reservoir of compounds which have the potential to overcome the MDR problem. Essential oils (EOs) can be used in their edible form or as medicinal oils with diverse benefits and lesser side effects. This book chapter presents the summarized information on the health benefits and antifungal mode of action of natural compounds isolated from EOs. Additionally, the use of nanosystems as a carrier and delivery system of various EOs on the target pathogen is also discussed.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Abuznait AH, Qosa H, Busnena BA, El Sayed KA, Kaddoumi A (2013) Olive-oil-derived oleocanthal enhances β-amyloid clearance as a potential neuroprotective mechanism against Alzheimer’s disease: in vitro and in vivo studies. ACS Chem Neurosci 4:973–982
Ahmad Z (2010) The uses and properties of almond oil. Complement Ther Clin Pract 16:10–12
Anghel I, Grumezescu AM, Holban AM, Ficai A, Anghel AG, Chifiriuc MC (2013) Biohybrid nanostructured iron oxide nanoparticles and Satureja hortensis to prevent fungal biofilm development. Int J Mol Sci 14:18110–18123. https://doi.org/10.3390/ijms140918110
Ansari MA, Fatima Z, Hameed S (2014) Sesamol: a natural phenolic compound with promising anticandidal potential. J Pathog 2014:895193. https://doi.org/10.1155/2014/895193
Ansari MA, Fatima Z, Hameed S (2016) Anticandidal effect and mechanisms of monoterpenoid, perillyl alcohol against Candida albicans. PLoS One 11(9):e0162465. https://doi.org/10.1371/journal.pone.0162465
Anyasor GN, Ogunwenmo KO, Oyelana OA, Ajayi D, Dangana J (2009) Chemical analyses of Groundnut (Arachis hypogaea) oil. Pak J Nutr 8:269–272
Avoseh O, Oyedeji O, Rungqu P, Nkeh-Chungag B, Oyedeji A (2015) Cymbopogon species; ethnopharmacology, phytochemistry and the pharmacological importance. Molecules 20:7438–7453
Bakkali F, Averbeck S, Averbeck D, Idaomar M (2008) Biological effects of essential oils – a review. Food Chem Toxicol 46:446–475
Bendini A, Cerretani L, Carrasco-Pancorbo A, Gómez-Caravaca AM, Segura-Carretero A, Fernández-Gutiérrez A, Lercker G (2007) Phenolic molecules in virgin olive oils: a survey of their sensory properties, health effects, antioxidant activity and analytical methods. An overview of the last decade. Molecules 12:1679–1719
Bergsson G, Arnfinnsson J, Steingrímsson O, Thormar H (2001) In vitro killing of Candida albicans by fatty acids and monoglycerides. Antimicrob Agents Chemother 45:3209–3212
Braga PC, Ricci D (2011) Thymol-induced alterations in Candida albicans imaged by atomic force microscopy. Methods Mol Biol 736:401–410
Carson CF, Hammer KA, Riley TV (2006) Melaleuca alternifolia (Tea Tree) oil: a review of antimicrobial and other medicinal properties. Clin Microbiol Rev 19:50–62
Cavanagh HM, Wilkinson JM (2002) Biological activities of lavender essential oil. Phytother Res 16:301–308
Chaieb K, Hajlaoui H, Zmantar T, Kahla-Nakbi AB, Rouabhia M, Mahdouani K, Bakhrouf A (2007) The chemical composition and biological activity of clove essential oil, Eugenia caryophyllata (Syzigium aromaticum L. Myrtaceae): a short review. Phytother Res 21:501–506
Claudia S, Dario L (2013) Candida infections, causes, targets, and resistance mechanisms: traditional and alternative antifungal agents. Biomed Res Int 2013:204237. https://doi.org/10.1155/2013/204237
Dhakad AK, Pandey VV, Beg S, Rawat JM, Singh A (2017) Biological, medicinal and toxicological significance of Eucalyptus leaf essential oil: a review. J Sci Food Agric. https://doi.org/10.1002/jsfa.8600
Dias IJ, Trajano ERIS, Castro RD, Ferreira GLS, Medeiros HCM, Gomes DQC (2017) Antifungal activity of linalool in cases of Candida spp. isolated from individuals with oral candidiasis. Braz J Biol. https://doi.org/10.1590/1519-6984.171054
Fazly Bazzaz BS, Khameneh B, Namazi N, Iranshahi M, Davoodi D, Golmohammadzadeh S (2018) Solid lipid nanoparticles carrying Eugenia caryophyllata essential oil: the novel nanoparticulate systems with broad-spectrum antimicrobial activity. Lett Appl Microbiol 66:506–513. https://doi.org/10.1111/lam.12886
Ghosh V, Mukherjee A, Chandrasekaran N (2012) Mustard oil microemulsion formulation and evaluation of bactericidal activity. Int J Pharm Pharm Sci 4:497–500
Gow NAR, Yadav B (2017) Microbe Profile: Candida albicans: a shape-changing, opportunistic pathogenic fungus of humans. Microbiology 163:1145–1147
Grumezescu AM, Chifiriuc MC, Saviuc C, Grumezescu V, Hristu R, Mihaiescu DE, Stanciu GA, Andronescu E (2012) Hybrid nanomaterial for stabilizing the antibiofilm activity of Eugenia carryophyllata essential oil. IEEE Trans Nanobiosci 11:360–365. https://doi.org/10.1109/TNB.2012.2208474
Guo S, Ge Y, Jom KN (2017) A review of phytochemistry, metabolite changes, and medicinal uses of the common sunflower seed and sprouts (Helianthus annuus L.). Chem Cent J 11:95. https://doi.org/10.1186/s13065-017-0328-7
Henderson ST, Vogel JL, Barr LJ, Garvin F, Jones JJ, Costantini LC (2009) Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer’s disease: a randomized, double-blind, placebo-controlled, multicenter trial. Nutr Metab (Lond) 6:31. https://doi.org/10.1186/1743-7075-6-31
Hsu CC, Lai WL, Chuang KC, Lee MH, Tsai YC (2013) The inhibitory activity of linalool against the filamentous growth and biofilm formation in Candida albicans. Med Mycol 51:473–482
Ivanov DS, Lević JD, Sredanović SA (2010) Fatty acid composition of various soybean products. Food Feed Res 37:65–70
Jassbi AR, Asadollahi M, Masroor M, Schuman MC, Mehdizadeh Z, Soleimani M, Miri R (2012) Chemical classification of the essential oils of the Iranian Salvia species in comparison with their botanical taxonomy. Chem Biodivers 9:1254–1271. https://doi.org/10.1002/cbdv.201100209
Kamil A, Chen CY (2012) Health benefits of almonds beyond cholesterol reduction. J Agric Food Chem 60:6694–6702
Kathiravan MK, Salake AB, Chothe AS et al (2012) The biology and chemistry of antifungal agents: a review. Bioorg Med Chem 20:5678–5698
Lalla RV, Patton LL, Dongari-Bagtzoglou A (2013) Oral candidiasis: pathogenesis, clinical presentation, , diagnosis and treatment strategies. J Calif Dent Assoc 41:263–268
Latifah-Munirah B, Himratul-Aznita WH, Zain NM (2015) Eugenol, an essential oil of clove, causes disruption to the cell wall of Candida albicans (ATCC 14053). PLoS One 10(2):e0117695. https://doi.org/10.1371/journal.pone.0117695.
Lee W, Lee DG (2014) An antifungal mechanism of curcumin lies in membrane-targeted action within Candida albicans. IUBMB Life 66:780–785
Lin L, Allemekinders H, Dansby A, Campbell L, Durance-Tod S, Berger A, Jones PJ (2013) Evidence of health benefits of canola oil. Nutr Rev 71:370–385
Marwa C, Fikri-Benbrahim K, Ou-Yahia D, Farah A (2017) African peppermint (Mentha piperita) from Morocco: Chemical composition and antimicrobial properties of essential oil. J Adv Pharm Technol Res 8:86–90
Máté G, Kovács D, Gazdag Z, Pesti M, Szántó Á (2017) Linalool-induced oxidative stress processes in the human pathogen Candida albicans. Acta Biol Hung 68:220–231
Nagpal M, Sood S (2013) Role of curcumin in systemic and oral health: an overview. J Nat Sci Biol Med 4:3–7
Ogbolu DO, Oni AA, Daini OA, Oloko AP (2007) In vitro antimicrobial properties of coconut oil on Candida species in Ibadan, Nigeria. J Med Food 10:384–387
Ozcan MM (2010) Some nutritional characteristics of kernel and oil of peanut (Arachis hypogaea L.). J Oleo Sci 59:1–5
Pan A, Chen M, Chowdhury R, Wu JH, Sun Q, Campos H, Mozaffarian D, Hu FB (2012) α-Linolenic acid and risk of cardiovascular disease: a systematic review and meta-analysis. Am J Clin Nutr 96:1262–1273
Piran P, Kafil HS, Ghanbarzadeh S, Safdari R, Hamishehkar H (2017) Formulation of menthol-loaded nanostructured lipid carriers to enhance its antimicrobial activity for food preservation. Adv Pharm Bull 7:261–268. https://doi.org/10.15171/apb.2017.031
Quiles JL, Ramı́rez-Tortosa MC, Gómez JA, Huertas JR, Mataix J (2002) Role of vitamin E and phenolic compounds in the antioxidant capacity, measured by ESR, of virgin olive, olive and sunflower oils after frying. Food Chem 76:461–468
Rao A, Zhang Y, Muend S, Rao R (2010) Mechanism of antifungal activity of terpenoid phenols resembles calcium stress and inhibition of the TOR pathway. Antimicrob Agents Chemother 54:5062–5069
Ruiz-Herrera J, Elorza MV, Valentín E, Sentandreu R (2006) Molecular organization of the cell wall of Candida albicans and its relation to pathogenicity. FEMS Yeast Res 6:14–29
Saibabu V, Singh S, Ansari MA, Fatima Z, Hameed S (2017) Insights into the intracellular mechanisms of citronellal in Candida albicans: implications for reactive oxygen species-mediated necrosis, mitochondrial dysfunction, and DNA damage. Rev Soc Bras Med Trop 50(4):524–529
Sakkas H, Papadopoulou C (2017) Antimicrobial activity of basil, oregano, and Thyme essential oils. J Microbiol Biotechnol 27:429–438
Samber N, Khan A, Varma A, Manzoor N (2015) Synergistic anti-candidal activity and mode of action of Mentha piperita essential oil and its major components. Pharm Biol 53:1496–1504
Sengupta A, Ghosh M (2011) Hypolipidemic effect of mustard oil enriched with medium chain fatty acid and polyunsaturated fatty acid. Nutrition 27:1183–1193
Sharma M, Manoharlal R, Puri N, Prasad R (2010) Antifungal curcumin induces reactive oxygen species and triggers an early apoptosis but prevents hyphae development by targeting the global repressor TUP1 in Candida albicans. Biosci Rep 30:391–404
Singh S, Fatima Z, Hameed S (2016a) Insights into the mode of action of anticandidal herbal monoterpenoid geraniol reveal disruption of multiple MDR mechanisms and virulence attributes in Candida albicans. Arch Microbiol 198:459–472
Singh S, Fatima Z, Hameed S (2016b) Citronellal induced disruption of membrane homeostasis in Candida albicans and attenuation of its virulence attributes. Rev Soc Bras Med Trop 49:465
Singh S, Fatima Z, Hameed S (2015) Predisposing factors endorsing Candida infections. Infrez Med 23:211–223
Singh S, Hans S, Fatima Z, Hameed S (2017) Overcoming fungal multidrug resistance by natural compounds targeting efflux pumps. Front Anti-Infect Drug Discov 7:1–12
Skorić D, Jocić S, Sakac Z, Lecić N (2008) Genetic possibilities for altering sunflower oil quality to obtain novel oils. Can J Physiol Pharmacol 86:215–221
Sobel JD (2007) Vulvovaginal candidiasis. Lancet 369:1961–1971
Sohail M, Rakha A, Butt MS, Iqbal MJ, Rashid S (2017) Rice bran nutraceutics: a comprehensive review. Crit Rev Food Sci Nutr 57:3771–3780
Somova LI, Shode FO, Ramnanan P, Nadar A (2003) Antihypertensive, antiatherosclerotic and antioxidant activity of triterpenoids isolated from Olea europaea, subspecies africana leaves. J Ethnopharmacol 84:299–305
Stanojevic LP, Marjanovic-Balaban ZR, Kalaba VD, Stanojevic JS, Cvetkovic DJ (2016) Chemical Composition, Antioxidant and Antimicrobial Activity of Chamomile Flowers Essential Oil (Matricaria chamomilla L.). J Essent Oil Bear Plants 19:2017–2028
Sun L, Liao K, Wang D (2015) Effects of magnolol and honokiol on adhesion, yeast-hyphal transition, and formation of biofilm by Candida albicans. PLoS One 10(2):e0117695. https://doi.org/10.1371/journal.pone.0117695
Sun LM, Zhang CL, Li P (2012) Characterization, antibiofilm, and mechanism of action of novel PEG-stabilized lipid nanoparticles loaded with terpinen-4-ol. J Agric Food Chem 60:6150–6156. https://doi.org/10.1021/jf3010405
Tanwar J, Das S, Fatima Z, Hameed S (2014) Multidrug resistance: an emerging crisis. Interdiscip Perspect Infect Dis 2014, 541340. https://doi.org/10.1155/2014/541340
Trinetta V, Morgan MT, Coupland JN, Yucel U (2017) Essential oils against pathogen and spoilage microorganisms of fruit juices: use of versatile antimicrobial delivery systems. J Food Sci 82(2):471–476
Vediyappan G, Dumontet V, Pelissier F, d’Enfert C (2013) Gymnemic acids inhibit hyphal growth and virulence in Candida albicans. PLoS One 8(9):e74189. https://doi.org/10.1371/journal.pone.0074189
Yordanov M, Dimitrova P, Patkar S, Saso L, Ivanovska N (2008) Inhibition of Candida albicans extracellular enzyme activity by selected natural substances and their application in Candida infection. Can J Microbiol 54:435–440
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Fatima, Z., Singh, S., Hameed, S. (2020). Nanophytotherapeutic Potential of Essential Oils Against Candida Infections. In: Saxena, S., Khurana, S. (eds) NanoBioMedicine. Springer, Singapore. https://doi.org/10.1007/978-981-32-9898-9_13
Download citation
DOI: https://doi.org/10.1007/978-981-32-9898-9_13
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-32-9897-2
Online ISBN: 978-981-32-9898-9
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)