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Protective Effect of Ganoderma (Lingzhi) on Cardiovascular System

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Ganoderma and Health

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1182))

Abstract

Cardiovascular diseases (CVDs) are disorders of the heart and blood vessels and include coronary heart diseases, cerebrovascular diseases, rheumatic heart diseases, and other conditions. CVDs are one of the most major causes of morbidity and mortality around the world, taking the lives of 17.9 million people every year. Several investigations have shown the influence of Ganoderma lucidum (G. lucidum, Lingzhi) on some metabolic markers, such as low-density lipoprotein (LDL), high-density lipoprotein (HDL), total cholesterol (TC), blood pressure, and oxidative damage. G. lucidum potentially reduces the risk of suffering cardiovascular diseases. Some studies found that G. lucidum prevented from heart damage in a variety of disease models, such as streptozotocin (STZ)-induced diabetic, high-fat-diet-induced diabetic, isoprenaline (ISO)-induced myocardial hypertrophy, acute ethanol-induced heart toxicity, and transverse aortic constriction (TAC) models. This chapter summarizes putative preventive and therapeutic effects of G. lucidum on cardiovascular diseases and the potential clinical use of G. lucidum involved in these effects.

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Acknowledgments

Research in the authors’ laboratory is supported by National Natural Science Foundation of China grants 81620108029, 81330074, 81261160507, 81974083 and 81170632, Beijing Natural Science Foundation grant 7172113, Drug Discovery Program grant 2009ZX09301-010-30, the Research Fund for the Doctoral Program of Higher Education 20100001110047, the 111 project, and International Science and Technology Cooperation Program of China 2012DFA11070.

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Authors and Affiliations

  1. State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China

    Jia Meng

  2. Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China

    Baoxue Yang

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  1. Jia Meng
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  2. Baoxue Yang
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Correspondence to Baoxue Yang .

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Editors and Affiliations

  1. Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China

    Zhibin Lin

  2. Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China

    Baoxue Yang

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Meng, J., Yang, B. (2019). Protective Effect of Ganoderma (Lingzhi) on Cardiovascular System. In: Lin, Z., Yang, B. (eds) Ganoderma and Health. Advances in Experimental Medicine and Biology, vol 1182. Springer, Singapore. https://doi.org/10.1007/978-981-32-9421-9_7

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