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Quorum Sensing and Multidrug Resistance Mechanism in Helicobacter pylori

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Implication of Quorum Sensing and Biofilm Formation in Medicine, Agriculture and Food Industry

Abstract

Antibiotics are integral components of medicine and therapy for majority of diseases. Despite the advancements in medical science, the therapeutic efficiency of major antibiotics is gradually decreasing due to increased antibiotic resistance in most of the bacterial species. The mechanisms involved in developing antibiotic resistance include modification of antibiotic molecules, reducing drug permeability, modification of target binding sites and biofilm formation. Nevertheless, reducing drug permeability and formation of biofilm are known to contribute antibiotic resistance in Helicobacter pylori. Further significant research is essential in improving the efficiency of eliminating bacterial infections. Therefore, this review contemplates on understanding the mechanisms involved in developing antibiotic resistance in pathogens and H. pylori.

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Acknowledgements

CS, NNR and TD are grateful to GITAM (Deemed to be University) for providing necessary facilities to carry out the research work and for extending constant support. PVBC is thankful to Krishna University Machilipatnam. TD is thankful for financial support in the form of DST Inspire Fellowship (IF 160964), Department of Science and Technology, New Delhi. The authors are also thankful to Dr Neha Merchant, Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, USA, for scientific and language editing.

Authors Contribution

CS and NNRR initiated the review; manuscript was written by all authors CS, TD, PVBC and NNRR and revised by CS, PVBC and NNRR.

Conflict of Interest Statement

The authors declare that there is no potential conflict of interest.

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Authors and Affiliations

  1. Department of Biochemistry and Bioinformatics, Institute of Science, Gandhi Institute of Technology and Management (GITAM) (Deemed-to-be University), Visakhapatnam, Andhra Pradesh, India

    Surekha Challa, Titash Dutta & Neelapu Nageswara Rao Reddy

  2. Department of Biotechnology, Krishna University, Machilipatnam, Andhra Pradesh, India

    Pallaval Veera Bramhachari

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  1. Surekha Challa
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  2. Titash Dutta
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  3. Pallaval Veera Bramhachari
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  4. Neelapu Nageswara Rao Reddy
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Correspondence to Neelapu Nageswara Rao Reddy .

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Editors and Affiliations

  1. Department of Biotechnology, Krishna University, Machilipatnam, Andhra Pradesh, India

    Pallaval Veera Bramhachari

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Challa, S., Dutta, T., Bramhachari, P.V., Rao Reddy, N.N. (2019). Quorum Sensing and Multidrug Resistance Mechanism in Helicobacter pylori. In: Bramhachari, P. (eds) Implication of Quorum Sensing and Biofilm Formation in Medicine, Agriculture and Food Industry . Springer, Singapore. https://doi.org/10.1007/978-981-32-9409-7_8

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