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Exhaled Breath CH4 and H2S Sensing Using Mid-IR Quantum Cascade Laser (QCL)

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Progress in Optomechatronics

Part of the book series: Springer Proceedings in Physics ((SPPHY,volume 249))

Abstract

Methane (CH4) and hydrogen sulfide (H2S) are two major trace molecules in exhaled air of IBS (Irritable Bowel Syndrome)-affected individuals. In this study, we have utilized a mid-IR continuous wave (cw) external cavity (EC)-quantum cascade laser (QCL) coupled cavity ring-down spectrometer (CRDS) for monitoring CH4 and H2S in exhaled air of human subjects who are suffering from IBS associated with halitosis. We probed the strong fundamental asymmetric bending vibrations of CH4 (ν4 bands) and H2S (ν2 bands) for the estimation of their concentrations in breath samples. The limiting sensitivity of CH4 and H2S detection has been achieved up to 29 ppbv and 289 ppbv (parts per billion by volume) respectively in this study. The present study paves the way to explore real-time future applications of mid-infrared optical gas-sensing in biomedical science.

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Acknowledgements

M. Pal acknowledges the Department of Science & Technology (DST, India) for Inspire Fellowships for conducting doctoral research. We sincerely thank Dr. Sujit Chaudhuri (AMRI Hospital, Saltlake, Kolkata) for his fruitful discussion in patients screening. Dr. M. Pradhan appreciatively acknowledges funding from the Ministry of Earth Sciences (MoES) Govt. of India (Grant no: MoES/16/26/12-RDEAS) and the SERB, Department of Science and Technology (DST), Govt. of India (Grant no: SB/S2/LOP-18/2013) for this research work.

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Authors and Affiliations

  1. Department of Chemical, Biological and Macromolecular Sciences, S. N. Bose National Centre for Basic Sciences, Salt Lake, JD Block, Sector III, Kolkata, 700106, India

    Mithun Pal & Manik Pradhan

  2. Technical Research Centre, S. N. Bose National Centre for Basic Sciences, Salt Lake, JD Block, Sector III, Kolkata, 700106, India

    Manik Pradhan

Authors
  1. Mithun Pal
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Correspondence to Manik Pradhan .

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Editors and Affiliations

  1. University of Calcutta, Kolkata, West Bengal, India

    Indrani Bhattacharya

  2. Center for Optical Research and Education, Utsunomiya University, Utsunomiya, Tochigi, Japan

    Yukitoshi Otani

  3. FEMTO-ST, The Université de Franche-Comté, Besancon, France

    Philippe Lutz

  4. Goa University, Goa, India

    Sudhir Cherukulappurath

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Pal, M., Pradhan, M. (2020). Exhaled Breath CH4 and H2S Sensing Using Mid-IR Quantum Cascade Laser (QCL). In: Bhattacharya, I., Otani, Y., Lutz, P., Cherukulappurath, S. (eds) Progress in Optomechatronics. Springer Proceedings in Physics, vol 249. Springer, Singapore. https://doi.org/10.1007/978-981-15-6467-3_11

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  • DOI: https://doi.org/10.1007/978-981-15-6467-3_11

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-15-6466-6

  • Online ISBN: 978-981-15-6467-3

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