Abstract
Pharmaceuticals and personal care products (PPCPs), such as disinfectants, fragrances (e.g., products for body cleaning, sunscreens, and lotions), household chemicals, and drugs to cure human and animal diseases, are considered to be the most emerging contaminants in water bodies. These products are known to transform slightly or are often unchanged with time and enter into the aquatic environment. Although PPCPs have been detected frequently throughout the world, they still remain unregulated or currently undergoing a regularization process. Various PPCPs are persistent or pseudo-persistent and deteriorate wastewater quality, human health as well as the ecosystem. Moreover, they are also known to be bio-accumulative in organisms. Thus, it is essential to find a solution to achieve an effective removal of these emerging pollutants before their discharge. The main objective of this work was an exclusive review of the existing literature on PPCPs removal from water. The pros and cons of the reported PPCPs removal processes are reviewed critically and presented in this paper.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Ahmed I, Jhung SH (2016) Adsorptive desulfurization and denitrogenation using metal-organic frameworks. J Hazard Mater 301:259–276
Alcock RE, Sweetman A, Jones KC (1999) Assessment of organic contaminant fate in waste water treatment plants. I Selected compounds and physicochemical properties. Chemosphere 38:2247–2262
Annabi C, Fourcade F, Soutrel I, Geneste F, Floner D, Bellakhal N, Amrane A (2016) Degradation of enoxacin antibiotic by the electro-fenton process, optimization, biodegradability improvement and degradation mechanism. J Environ Manag 165:96–105
Ay F, Kargi F (2010) Advanced oxidation of amoxicillin by Fenton’s reagent treatment. J Hazard Mater 179:622–627
Bai Z, Yang Q, Wang J (2016) Catalytic ozonation of sulfamethazine antibiotics using Ce0.1Fe0.9OOH, Catalyst preparation and performance. Chemosphere. 161:174–180
Barea E, Montoro C, Navarro JA (2014) Toxic gas removal–metal–organic frameworks for the capture and degradation of toxic gases and vapours. Chem Soc Rev 43:5419–5430
Bautitz IR, Nogueira RFP (2007) Degradation of tetracycline by photo-Fenton process—Solar irradiation and matrix effects. J Photochem Photobiol Chem 187:33–39
Bhadra BN, Cho KH, Khan NA, Hong DY, Jhung SH (2015) Liquid-phase adsorption of aromatics over a metal–organic framework and activated carbon, effects of hydrophobicity/hydrophilicity of adsorbents and solvent polarity. J Phys Chem C.119:26620–26627
Dias IN, Souza BS, Pereira JH, Moreira FC, Dezotti M, Boaventura, RA, Vilar VJ (2014) Enhancement of the photo-Fenton reaction at near neutral pH through the use of ferrioxalate complexes, a case study on trimethoprim and sulfamethoxazole antibiotics removal from aqueous solutions. Chem Eng J 247:302–313
Bokare AD, Choi W (2014) Review of iron-free Fenton-like systems for activating H2O2 in advanced oxidation processes. J Hazard Mater 275:121–135
Calamari D, Zuccato E, Castiglioni S, Bagnati R, Fanelli R (2003) Strategic survey of therapeutic drugs in the rivers Po and Lambro in northern Italy. Environ Sci Technol 37:1241–1248
Carballa M, Omil F, Ternes T, Lema JM (2007) Fate of pharmaceutical and personal care products (PPCPs) during anaerobic digestion of sewage sludge. Water Res 41:2139–2150
Chen N, Huang L, Liu N, Liu Y, Wang S (2013) Analysis of the effect of erythromycin wastewater degradation by Fenton Method. Asian J Chem 25:7208
Cheng A, Wang L, Wang X, Zhang H, Zhang L, Zhang R, Wang Z (2008) Nanofiltration membrane removal trace steroidal estrogen. Membr Sci Technol 28:90–93
Darbre PD, Harvey PW (2008) Paraben esters, review of recent studies of endocrine toxicity, absorption, esterase and human exposure, and discussion of potential human health risks. J Appl Toxicol 28:561–578
Darbre PD, Aljarrah A, Miller WR, Coldham NG, Sauer MJ, Pope GS (2004) Concentrations of parabens in human breast tumours. J Appl Toxicol 24:5–13
Daughton CG (2004) Non-regulated water contaminants, emerging research. Environ Impact Assess Rev 24:711–732
Daughton CG, Ternes TA (1999) Pharmaceuticals and personal care products in the environment, agents of subtle change? Environ Health Perspect 107:907
De la Cruz N, Gimenez J, Esplugas S, Grandjean D, de Alencastro LF, Pulgarin C (2012) Degradation of 32 emergent contaminants by UV and neutral photo-fenton in domestic wastewater effluent previously treated by activated sludge. Water Res 46:1947–1957
DeCoste JB, Peterson GW (2014) Metal–organic frameworks for air purification of toxic chemicals. Chem Rev 114:5695–5727
Dirany A, Efremova AS, Oturan N, Sires I, Oturan MA, Aaron JJ (2011) Study of the toxicity of sulfamethoxazole and its degradation products in water by a bioluminescence method during application of the electro-Fenton treatment. Anal Bioanal Chem 400:353–360
Esplugas S, Bila DM, Krause LG, Dezotti M (2007) Ozonation and advanced oxidation technologies to remove endocrine disrupting chemicals (EDCs) and pharmaceuticals and personal care products (PPCPs) in water effluents. J Hazard Mater 149:131–142
Feng X, Ding S, Tu J, Wu F, Deng N (2005) Degradation of estrone in aqueous solution by photo-Fenton system. Sci Total Environ 345:229–237
Feng L, Hullebusch ED, Van Rodrigo MA, Esposito G, Oturan MA (2013) Removal of residual anti-inflammatory and analgesic pharmaceuticals from aqueous systems by electrochemical advanced oxidation processes, a review. Chem Eng J 228:944–964
Fent K, Weston AA (2006) Caminada D. Ecotoxicology of human pharmaceuticals. Aquat Toxicol 76:122–159
Furukawa H, Cordova KE, O’Keeffe M, Yaghi OM (2013) The chemistry and applications of metal-organic frameworks. Science 341:1230444
Gobel A, Thomsen A, McArdell CS, Joss A, Giger W (2005) Occurrence and sorption behavior of sulfonamides, macrolides, and trimethoprim in activated sludge treatment. Environ Sci Technol 39:3981–3989
Goi A, Veressinina Y, Trapido M (2008) Degradation of salicylic acid by Fenton and modified Fenton treatment. Chem Eng J 143:1–9
Halling-Sorensen B, Nors Nielsen S, Lanzky PF, Ingerslev F, Holten Lutzhoft HC, Jorgensen SE (1998) Occurrence, fate and effects of pharmaceutical substances in the environment–a review. Chemosphere 36:357–393
Hasan Z, Jhung SH (2015) Removal of hazardous organics from water using metal-organic frameworks (MOFs), plausible mechanisms for selective adsorptions. J Hazard Mater 283:229–239
Hasan Z, Jeon J, Jhung SH (2012) Adsorptive removal of naproxen and clofibric acid from water using metal-organic frameworks. J Hazard Mater 209:151–157
Hasan Z, Choi EJ, Jhung SH (2013) Adsorption of naproxen and clofibric acid over a metal–organic framework MIL-101 functionalized with acidic and basic groups. Chem Eng J 219:537–544
He S, Wang J, Ye L, Zhang Y, Yu J (2014) Removal of diclofenac from surface water by electron beam irradiation combined with a biological aerated filter. Radiat Phys Chem 105:104–108
Heberer T (2002) Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment, a review of recent research data. Toxicol Lett 131:5–17
Hernando MD, Fernandez-Alba AR, Tauler R, Barcelo D (2005) Toxicity assays applied to wastewater treatment. Talanta 65:358–366
Ho YS (2006) Review of second-order models for adsorption systems. J Hazard Mater 136:681–689
Hu J, Wang J (2007) Degradation of chlorophenols in aqueous solution by γ-radiation. Radiat Phys Chem 76:1489–1492
Hwang YK, Hong DY, Chang JS, Jhung SH, Seo YK, Kim J, Vimont A, Daturi M, Serre C, Férey G (2008) Amine grafting on coordinatively unsaturated metal centers of MOFs, consequences for catalysis and metal encapsulation. Angew Chemie Int Ed 47:4144–4148
Janex-Habibi ML, Bruchet A, Ternes TA (2004) Effet des traitements d’eau potable et d’e´puration des eaux use´es sur les re´sidus me´dicamenteux. Re´sultats du projet Poseidon. Tech Sci Me´thodes 11:59–67
Jhung SH, Khan NA, Hasan Z (2012) Analogous porous metal–organic frameworks, synthesis, stability and application in adsorption. Cryst Eng Comm 14:7099–7109
Jiang JQ, Yang CX, Yan XP (2013) Zeolitic imidazolate framework-8 for fast adsorption and removal of benzotriazoles from aqueous solution. ACS Appl Mater Interfaces 5:9837–9842
Jones OA, Voulvoulis N, Lester JN (2004) Potential ecological and human health risks associated with the presence of pharmaceutically active compounds in the aquatic environment. Crit Rev Toxicol 34:335–350
Jorgensen SE, Halling-Sorensen B (2000) Drugs in the environment. Chemosphere 40:691–699
Kaczmarek M, Lis S (2009) Chemiluminescence determination of tetracyclines using Fenton system in the presence europium(III) ions. Anal Chim Acta 639:96–100
Keen OS, Linden KG (2013) Degradation of antibiotic activity during UV/H2O2 advanced oxidation and photolysis in wastewater effluent. Environ Sci Technol 47:13020–13030
Khan NA, Hasan Z, Jhung SH (2013) Adsorptive removal of hazardous materials using metal-organic frameworks (MOFs), a review. J Hazard Mater 244:444–456
Kim I, Yamashita N, Tanaka H (2009) Performance of UV and UV/H2O2 processes for the removal of pharmaceuticals detected in secondary effluent of a sewage treatment plant in Japan. J Hazard Mater 166:1134–1140
Kim HY, Lee OM, Kim TH, Yu S (2015) Enhanced biodegradability of pharmaceuticals and personal care products by ionizing radiation. Water Environ Res 87:321–325
Kimura A, Osawa M, Taguchi M (2012) Decomposition of persistent pharmaceuticals in wastewater by ionizing radiation. Radiat Phys Chem 81:1508–1512
Kinney CA, Furlong ET, Werner SL, Cahill JD (2006) Presence and distribution of wastewater-derived pharmaceuticals in soil irrigated with reclaimed water. Environ Toxicol Chem 25:317–326
Kummerer K (2001) Drugs in the environment, emission of drugs, diagnostic aids and disinfectants into wastewater by hospitals in relation to other sources–a review. Chemosphere 45:957–969
Kummerer K (2009) The presence of pharmaceuticals in the environment due to human use–present knowledge and future challenges. J Environ Manag 90:2354–2366
Larsen TA, Lienert J, Joss A, Siegrist H (2004) How to avoid pharmaceuticals in the aquatic environment. J Biotechnol 113:295–304
Li W, Nanaboina V, Zhou Q, Korshin GV (2012) Effects of Fenton treatment on the properties of effluent organic matter and their relationships with the degradation of pharmaceuticals and personal care products. Water Res 46:403–412
Li W, Shi Y, Gao L, Liu J, Cai Y (2015) Occurrence, fate and risk assessment of parabens and their chlorinated derivatives in an advanced wastewater treatment plant. J Hazard Mater 300:29–38
Liu Y, Wang J (2013) Degradation of sulfamethazine by gamma irradiation in the presence of hydrogen peroxide. J Hazard Mater 250–251:99–105
Liu FF, Zhao J, Wang S, Du P, Xing B (2014a) Effects of solution chemistry on adsorption of selected pharmaceuticals and personal care products (PPCPs) by graphenes and carbon nanotubes. Environ Sci Technol 48:13197–13206
Liu Y, Hu J, Wang J (2014b) Fe2+ enhancing sulfamethazine degradation in aqueous solution by gamma irradiation. Radiat Phys Chem 96:81–87
Loftus L, Jin G, Armstrong S, Bierma T, Walker P, Zheng W, Kelly W (2015) Fate of pharmaceutical and personal care products in irrigated wastewater effluent. ISTC Reports
Loraine GA, Pettigrove ME (2006) Seasonal variations in concentrations of pharmaceuticals and personal care products in drinking water and reclaimed wastewater in southern California. Environ Sci Technol 40:687–695
Ma X, Zhang C, Deng J, Song Y, Li Q, Guo Y, Li C (2015) Simultaneous degradation of estrone, 17beta-Estradiol and 17alpha-Ethinyl estradiol in an aqueous UV/H(2)O(2) system. Int J Environ Res Public Heal 12:12016–12029
McGregor D (2007) Hydroquinone, an evaluation of the human risks from its carcinogenic and mutagenic properties. Crit Rev Toxicol 37:887–914
Michael I, Hapeshi E, Michael C, Fatta-Kassinos D (2010) Solar Fenton and solar TiO2 catalytic treatment of ofloxacin in secondary treated effluents, evaluation of operational and kinetic parameters. Water Res 44:5450–5462
Miller D, Wheals BB, Beresford N, Sumpter JP (2001) Estrogenic activity of phenolic additives determined by an in vitro yeast bioassay. Environ Health Perspect 109:133–138
Nielsen L, Biggs MJ, Skinner W, Bandosz TJ (2014) The effects of activated carbon surface features on the reactive adsorption of carbamazepine and sulfamethoxazole. Carbon 80:419–432
Nowotny N, Epp B, von Sonntag C, Fahlenkamp H (2007) Quantification and modeling of the elimination behavior of ecologically problematic wastewater micropollutants by adsorption on powdered and granulated activated carbon. Environ Sci Technol 41:2050–2055
NTP (1989) NTP toxicology and carcinogenesis studies of hydroquinone (CAS No. 123-31-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Onesios KM, Yu JT, Bouwer EJ (2009) Biodegradation and removal of pharmaceuticals and personal care products in treatment systems, a review. Biodegradation 20:441–466
Petrovic M, de Alda MJ, Diaz-Cruz S, Postigo C, Radjenovic J, Gros M, Barcelo D (2009) Fate and removal of pharmaceuticals and illicit drugs in conventional and membrane bioreactor wastewater treatment plants and by riverbank filtration. Philos Trans A Math Phys Eng Sci 367:3979–4003
Plazinski W (2010) Applicability of the film-diffusion model for description of the adsorption kinetics at the solid/solution interfaces. Appl Surf Sci 256:5157–5163
Polo AS, López-Peñalver J, Sánchez-Polo M, Rivera-Utrilla J, Velo-Gala I, Salazar-Rábago J (2016) Oxidation of diatrizoate in aqueous phase by advanced oxidation processes based on solar radiation. J Photochem Photobiol Chem 319:87–95
Radjenovic J, Petrovic M, Barcelo D (2007) Analysis of pharmaceuticals in wastewater and removal using a membrane bioreactor. Anal Bioanal Chem 387:1365–1377
Radjenović J, Petrović M, Ventura F, Barceló D (2008) Rejection of pharmaceuticals in nanofiltration and reverse osmosis membrane drinking water treatment. Water Res 42:3601–3610
Richardson ML, Bowron JM (1985) The fate of pharmaceutical chemicals in the aquatic environment. J Pharm Pharmacol 37:1–12
Röhricht M, Krisam J, Weise U, Kraus UR, Düring RA (2010) Elimination of pharmaceuticals from wastewater by submerged nanofiltration plate modules. Desalination 250:1025–1026
Rosal R, Gonzalo MS, Rodrı´guez A, Garcı´a-Calvo E (2009) Ozonation of clofibric acid catalyzed by titanium dioxide. J Hazard Mater 169:411–418
Rosenfeldt EJ, Linden KG (2004) Degradation of endocrine disrupting chemicals bisphenol A, ethinyl estradiol, and estradiol during UV photolysis and advanced oxidation processes. Environ Sci Technol 38:5476–5483
Sanchez-Polo M, Lopez-Penalver J, Prados-Joya G, Ferro-Garcia MA, Rivera-Utrilla J (2099) Gamma irradiation of pharmaceutical compounds, nitroimidazoles, as a new alternative for water treatment. Water Res 43:4028–4036
Shah NS, Khan JA, Nawaz S, Khan HM (2014) Role of aqueous electron and hydroxyl radical in the removal of endosulfan from aqueous solution using gamma irradiation. J Hazard Mater 278:40–48
Siegrist H, Joss A (2004) Scrutinizing pharmaceuticals and personal care products in wastewater treatment. Environ Sci Technol 38:392–399
Song C, Wang C, Li H (2009) Several mechanism for removing drugs and personal care products in wastewater treatment and comparison. J Environ Eng 3:1921–1930
Stahlhut RW, van Wijngaarden E, Dye TD, Cook S, Swan SH (2007) Concentrations of urinary phthalate metabolites are associated with increased waist circumference and insulin resistance in adult U.S. males. Environ Health Perspect 115:876–882
Suarez S, Lema JM, Omil F (2010) Removal of pharmaceutical and personal care products (PPCPs) under nitrifying and denitrifying conditions. Water Res 44:3214–3224
Ternes TA, Martin M, Derek M, Frank S, Heinz-ju RB, Brigitte HG, Ninette Z (2002) Removal of pharmaceuticals during drinking water treatment. Environ Sci Technol 36:3855–3863
Ternes TA, Bonerz M, Herrmann N, Teiser B, Andersen HR (2007) Irrigation of treated wastewater in Braunschweig, Germany, an option to remove pharmaceuticals and musk fragrances. Chemosphere 66:894–904
Trovó AG, Melo SAS, Nogueira RFP (2008) Photodegradation of the pharmaceuticals amoxicillin, bezafibrate and paracetamol by the photo-Fenton process—application to sewage treatment plant effluent. J Photochem Photobiol Chem 198:215–220
USEPA Pharmaceuticals and personal care products (PPCPs) (2014) Environmental Protection Agency, Washington, DC, United States
Veloutsou S, Bizani E, Fytianos K (2014) Photo-Fenton decomposition of beta-blockers atenolol and metoprolol; study and optimization of system parameters and identification of intermediates. Chemosphere 107:180–186
Vogna D, Marotta R, Napolitano A, Andreozzi R, d’Ischia M (2004) Advanced oxidation of the pharmaceutical drug diclofenac with UV/H2O2 and ozone. Water Res 38:414–422
Wan Z, Wang J (2016) Ce–Fe-reduced graphene oxide nanocomposite as an efficient catalyst for sulfamethazine degradation in aqueous solution. Environ Sci Pollut Res Int 23:185442–185451
Wang J, Chu L (2016) Irradiation treatment of pharmaceutical and personal care products (PPCPs) in water and wastewater, an overview. Radiat Phys Chem 125:56–64
Wang J, Wang S (2016) Removal of pharmaceuticals and personal care products (PPCPs) from wastewater, A review. J Environ Manag 182:620–640
Wang XL, Wang WN, Wang DX (2002) Experimental investigation on separation performance of nanofiltration membranes for inorganic electrolyte solutions. Desalination 145:115–122
Wu H, Gong Q, Olson DH, Li J (2012) Commensurate adsorption of hydrocarbons and alcohols in microporous metal organic frameworks. Chem Rev 112:836–868
Xu J, Wu L, Chang AC (2009) Degradation and adsorption of selected pharmaceuticals and personal care products (PPCPs) in agricultural soils. Chemosphere 77:1299–1305
Xue J, Wang J (2008) Radiolysis of pentachlorophenol (PCP) in aqueous solution by gamma radiation. J Environ Sci 20:1153–1157
Yang Q, Liu D, Zhong C, Li JR (2013) Development of computational methodologies for metal–organic frameworks and their application in gas separations. Chem Rev 113:8261–8323
Yu S, Hu J, Wang J (2010) Gamma radiation-induced degradation of p-nitrophenol (PNP) in the presence of hydrogen peroxide (H2O2) in aqueous solution. J Hazard Mater 177:1061–1067
Yuan F, Hu C, Hu X, Wei D, Chen Y, Qu J (2011) Photodegradation and toxicity changes of antibiotics in UV and UV/H2O2 process. J Hazard Mater 185:1256–1263
Zhang Z, Yang Q, Wang J (2016) Degradation of trimethoprim by gamma irradiation in the presence of persulfate. Radiat Phys Chem 127:85–91
Zheng B, Zheng Z, Zhang J, Luo X, Wang J, Liu Q, Wang L (2011) Degradation of the emerging contaminant ibuprofen in aqueous solution by gamma irradiation. Desalination 276:379–385
Zuccato E, Castiglioni S, Fanelli R, Reitano G, Bagnati R, Chiabrando C, Pomati F, Rossetti C, Calamari D (2006) Pharmaceuticals in the environment in Italy, causes, occurrence, effects and control. Environ Sci Pollut Res Int 13:15–21
Zwiener C, Frimmel FH (2000) Oxidative treatment of pharmaceuticals in water. Water Res 34:1881–1885
Acknowledgements
SM and PB would like to thank Jadavpur University for the financial support under JU-RUSA 2.0 department project scheme (File no-R11/631/19, Dated 11/06/2019). AB acknowledges the University Grants Commission for providing research opportunity with the Dr. D. S. Kothari postdoctoral fellowship (UGC-DSKPDF, File No: F.4-2/2006 (BSR)/OT/18-19/0009).
Contribution
UR and SM have contributed equally to this work.
Conflict of Interest
Authors declare no conflict of interest for this work.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2021 Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Manna, S., Roy, U., Biswas, A., Sengupta, S., Basak, P., Das, P. (2021). Review on Trends in the Removal of Pharmaceuticals and Personal Care Products (PPCPs) from Water and Wastewater. In: Kumar, M., Snow, D., Honda, R., Mukherjee, S. (eds) Contaminants in Drinking and Wastewater Sources. Springer Transactions in Civil and Environmental Engineering. Springer, Singapore. https://doi.org/10.1007/978-981-15-4599-3_10
Download citation
DOI: https://doi.org/10.1007/978-981-15-4599-3_10
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-15-4598-6
Online ISBN: 978-981-15-4599-3
eBook Packages: EngineeringEngineering (R0)