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Artificial Intelligence in Retinal Vascular Imaging

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Retinal Vascular Disease

Part of the book series: Retina Atlas ((RA))

Abstract

Artificial intelligence (AI) has flourished in the last decade due to the emergence of deep learning, a class of machine learning algorithms dedicated to building large artificial neural network models capable of learning through exposure to large amounts of data. Ophthalmology, and especially retinal science, are at the forefront of AI applications in medicine, with a fully autonomous AI image-based diagnostic system that has recently been approved by the FDA as a first of its kind in medicine (Abramoff et al. 2018; Topol 2019).

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References

  • Abramoff MD, Garvin MK, Sonka M. Retinal imaging and image analysis. IEEE Rev Biomed Eng. 2010;3:169–208.

    Article  Google Scholar 

  • Abramoff M, Lavin PT, Birch M, Shah N, Folk J. Pivotal trial of an autonomous AI-based diagnostic system for detection of diabetic retinopathy in primary care offices. Nat Partner J. 2018;1.

    Google Scholar 

  • Anegondi N, Chidambara L, Bhanushali D, Gadde SGK, Yadav NK, Sinha Roy A. An automated framework to quantify areas of regional ischemia in retinal vascular diseases with OCT angiography. J Biophotonics. 2018;11:e201600312.

    Article  Google Scholar 

  • Campbell JP, Zhang M, Hwang TS, Bailey ST, Wilson DJ, Jia Y, Huang D. Detailed vascular anatomy of the human retina by projection-resolved optical coherence tomography angiography. Sci Rep. 2017;7:42201.

    Article  CAS  Google Scholar 

  • Cheung CY, Zheng Y, Hsu W, Lee ML, Lau QP, Mitchell P, Wang JJ, Klein R, Wong TY. Retinal vascular tortuosity, blood pressure, and cardiovascular risk factors. Ophthalmology. 2011;118:812–8.

    Article  Google Scholar 

  • Dashtbozorg B, Mendonca AM, Campilho A. An automatic graph-based approach for artery/vein classification in retinal images. IEEE Trans Image Process. 2014;23:1073–83.

    Article  Google Scholar 

  • De Fauw J, Ledsam JR, Romera-Paredes B, Nikolov S, Tomasev N, Blackwell S, Askham H, Glorot X, O’Donoghue B, Visentin D, et al. Clinically applicable deep learning for diagnosis and referral in retinal disease. Nat Med. 2018;24:1342–50.

    Article  Google Scholar 

  • Doubal FN, MacGillivray TJ, Patton N, Dhillon B, Dennis MS, Wardlaw JM. Fractal analysis of retinal vessels suggests that a distinct vasculopathy causes lacunar stroke. Neurology. 2010;74:1102–7.

    Article  CAS  Google Scholar 

  • Ganjee R, Moghaddam ME, Nourinia R. Automatic segmentation of abnormal capillary nonperfusion regions in optical coherence tomography angiography images using marker-controlled watershed algorithm. J Biomed Opt. 2018;23:1–16.

    Article  Google Scholar 

  • Ghashut R, Muraoka Y, Ooto S, Iida Y, Miwa Y, Suzuma K, Murakami T, Kadomoto S, Tsujikawa A, Yoshimura N. Evaluation of macular ischemia in eyes with central retinal vein occlusion: an optical coherence tomography angiography study. Retina. 2018;38:1571–80.

    Article  Google Scholar 

  • Gulshan V, Peng L, Coram M, Stumpe MC, Wu D, Narayanaswamy A, Venugopalan S, Widner K, Madams T, Cuadros J, et al. Development and validation of a deep learning algorithm for detection of diabetic retinopathy in retinal fundus photographs. JAMA. 2016;316:2402–10.

    Article  Google Scholar 

  • Huang F, Dashtbozorg B, Tan T, Ter Haar Romeny BM. Retinal artery/vein classification using genetic-search feature selection. Comput Methods Prog Biomed. 2018;161:197–207.

    Article  Google Scholar 

  • Hwang TS, Gao SS, Liu L, Lauer AK, Bailey ST, Flaxel CJ, Wilson DJ, Huang D, Jia Y. Automated quantification of capillary nonperfusion using optical coherence tomography angiography in diabetic retinopathy. JAMA Ophthalmol. 2016;134:367–73.

    Article  Google Scholar 

  • Kermany DS, Goldbaum M, Cai W, Valentim CCS, Liang H, Baxter SL, McKeown A, Yang G, Wu X, Yan F, et al. Identifying medical diagnoses and treatable diseases by image-based deep learning. Cell. 2018;172:1122–31e1129.

    Article  CAS  Google Scholar 

  • Klein R, Klein BE, Moss SE, Wong TY, Sharrett AR. Retinal vascular caliber in persons with type 2 diabetes: the Wisconsin epidemiological study of diabetic retinopathy: XX. Ophthalmology. 2006;113:1488–98.

    Article  Google Scholar 

  • Krause J, Gulshan V, Rahimy E, Karth P, Widner K, Corrado GS, Peng L, Webster DR. Grader variability and the importance of reference standards for evaluating machine learning models for diabetic retinopathy. Ophthalmology. 2018;125:1264–72.

    Article  Google Scholar 

  • Niemeijer M, van Ginneken B, Staal J, Suttorp-Schulten MS, Abramoff MD. Automatic detection of red lesions in digital color fundus photographs. IEEE Trans Med Imaging. 2005;24:584–92.

    Article  Google Scholar 

  • Niemeijer M, Abramoff MD, van Ginneken B. Image structure clustering for image quality verification of color retina images in diabetic retinopathy screening. Med Image Anal. 2006;10:888–98.

    Article  Google Scholar 

  • Niemeijer M, van Ginneken B, Russell SR, Suttorp-Schulten MS, Abramoff MD. Automated detection and differentiation of drusen, exudates, and cotton-wool spots in digital color fundus photographs for diabetic retinopathy diagnosis. Invest Ophthalmol Vis Sci. 2007;48:2260–7.

    Article  Google Scholar 

  • Poplin R, Varadarajan AV, Blumer K, Liu Y, McConnell MV, Corrado GS, Peng L, Webster DR. Prediction of cardiovascular risk factors from retinal fundus photographs via deep learning. Nat Biomed Eng. 2018;2:158–64.

    Article  Google Scholar 

  • Sabanayagam C, Banu R, Chee ML, Lee R, Wang YX, Tan G, Jonas JB, Lamoureux EL, Cheng C-Y, Klein BEK, et al. Incidence and progression of diabetic retinopathy: a systematic review. Lancet Diabetes Endocrinol. 2019;7:140–9.

    Article  Google Scholar 

  • Sayres, R, Taly A, Rahimy E, Blumer K, Coz D, Hammel N, Krause J, Narayanaswamy A, Rastegar Z, Wu D, et al. Using a deep learning algorithm and integrated gradients explanation to assist grading for diabetic retinopathy. Ophthalmology. 2019;126(4):552–64.

    Google Scholar 

  • Schlegl T, Waldstein SM, Bogunovic H, Endstrasser F, Sadeghipour A, Philip AM, Podkowinski D, Gerendas BS, Langs G, Schmidt-Erfurth U. Fully automated detection and quantification of macular fluid in OCT using deep learning. Ophthalmology. 2018;125:549–58.

    Article  Google Scholar 

  • Schmidt-Erfurth U, Sadeghipour A, Gerendas BS, Waldstein SM, Bogunovic H. Artificial intelligence in retina. Prog Retin Eye Res. 2018;67:1–29.

    Article  Google Scholar 

  • Seidelmann SB, Claggett B, Bravo PE, Gupta A, Farhad H, Klein BE, Klein R, Di Carli M, Solomon SD. Retinal vessel calibers in predicting long-term cardiovascular outcomes: the atherosclerosis risk in communities study. Circulation. 2016;134:1328–38.

    Article  Google Scholar 

  • Sharma S, Toth CA, Daniel E, Grunwald JE, Maguire MG, Ying GS, Huang J, Martin DF, Jaffe GJ, Comparison of Age-related Macular Degeneration Treatments Trials Research, G. Macular morphology and visual acuity in the second year of the comparison of age-related macular degeneration treatments trials. Ophthalmology. 2016;123:865–75.

    Article  Google Scholar 

  • Spaide RF, Fujimoto JG, Waheed NK, Sadda SR, Staurenghi G. Optical coherence tomography angiography. Prog Retin Eye Res. 2018;64:1–55.

    Article  Google Scholar 

  • Tang L, Niemeijer M, Reinhardt JM, Garvin MK, Abramoff MD. Splat feature classification with application to retinal hemorrhage detection in fundus images. IEEE Trans Med Imaging. 2013;32:364–75.

    Article  Google Scholar 

  • Ting DSW, Cheung CY, Lim G, Tan GSW, Quang ND, Gan A, Hamzah H, Garcia-Franco R, San Yeo IY, Lee SY, et al. Development and validation of a deep learning system for diabetic retinopathy and related eye diseases using retinal images from multiethnic populations with diabetes. JAMA. 2017;318:2211–23.

    Article  Google Scholar 

  • Topol EJ. High-performance medicine: the convergence of human and artificial intelligence. Nat Med. 2019;25:44–56.

    Article  CAS  Google Scholar 

  • Waldstein SM, Wright J, Warburton J, Margaron P, Simader C, Schmidt-Erfurth U. Predictive value of retinal morphology for visual acuity outcomes of different ranibizumab treatment regimens for neovascular AMD. Ophthalmology. 2016;123:60–9.

    Article  Google Scholar 

  • Xu X, Ding W, Abramoff MD, Cao R. An improved arteriovenous classification method for the early diagnostics of various diseases in retinal image. Comput Methods Prog Biomed. 2017;141:3–9.

    Article  Google Scholar 

  • Xue J, Camino A, Bailey ST, Liu X, Li D, Jia Y. Automatic quantification of choroidal neovascularization lesion area on OCT angiography based on density cell-like P systems with active membranes. Biomed Opt Express. 2018;9:3208–19.

    Article  Google Scholar 

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Correspondence to Ursula Schmidt-Erfurth .

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Schmidt-Erfurth, U., Riedl, S., Michl, M., Bogunović, H. (2020). Artificial Intelligence in Retinal Vascular Imaging. In: Sheyman, A., Fawzi, A.A. (eds) Retinal Vascular Disease. Retina Atlas. Springer, Singapore. https://doi.org/10.1007/978-981-15-4075-2_13

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  • DOI: https://doi.org/10.1007/978-981-15-4075-2_13

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-15-4074-5

  • Online ISBN: 978-981-15-4075-2

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