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Fertility Preservation in Women with Autoimmune Diseases Treated with Gonadotoxic Agents

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Women's Health in Autoimmune Diseases
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Abstract

Auto-immune diseases commonly affect women of reproductive age group. These women most often need chemotherapeutic agents which may cause significant gonado-toxicity. Therefore, fertility preservation techniques must be offered to women undergoing treatment for auto-immune diseases before starting such therapy. This chapter discusses in detail the various fertility preservation techniques available with their merits and de-merits.

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References

  1. Katsifis GE, Tzioufas AG (2004) Ovarian failure in systemic lupus erythematosus patients treated with pulsed intravenous cyclophosphamide. Lupus 13(9):673–678

    Article  CAS  Google Scholar 

  2. Austin HA, Klippel JH, Balow JE et al (1986) Therapy of lupus nephritis. Controlled trial of prednisone and cytotoxic drugs. N Engl J Med 314:614–619

    Article  Google Scholar 

  3. Hall AG, Tilby MJ (1992) Mechanisms of action of, and modes of resistance to, alkylating agents used in the treatment of haematological malignancies. Blood Rev 6(3):163–173

    Article  CAS  Google Scholar 

  4. Bines J, Oleske DM, Cobleigh MA (1996) Ovarian function in premenopausal women treated with adjuvant chemotherapy for breast cancer. J Clin Oncol 14(5):1718–1729

    Article  CAS  Google Scholar 

  5. Huong DLT, Amoura Z, Duhaut P et al (2002) Risk of ovarian failure and fertility after intravenous cyclophosphamide. A study in 84 patients. J Rheumatol 29:2571–2576

    CAS  PubMed  Google Scholar 

  6. Mok CC, Ho CTK, Chan KW, Lau CS, Wong RWS (2002) Outcome and prognostic indicators of diffuse proliferative lupus glomerulonephritis treated with sequential oral cyclophosphamide and azathioprine. Arthritis Rheum 46:1003–1013

    Article  CAS  Google Scholar 

  7. Mok CC, Lau CS, Wong RWS (1998) Risk factors for ovarian failure in patients with systemic lupus erythematosus receiving cyclophosphamide therapy. Arthritis Rheum 41:831–837

    Article  CAS  Google Scholar 

  8. Wetzels JFM (2004) Cyclophosphamide induced gonadal toxicity: a treatment dilemma in patients with lupus nephritis? Neth J Med 62(10):347–352

    CAS  PubMed  Google Scholar 

  9. Ioannidis JPA, Katsifis GE, Tzioufas AG, Moutsopoulos HM (2002) Predictors of sustained amenorrhoea from pulsed intravenous cyclophosphamide in premenopausal women with systemic lupus erythematosus. J Rheumatol 29:2129–2135

    CAS  PubMed  Google Scholar 

  10. Ben-Aharon I, Gafter-Gvili A, Leibovici L, Stemmer SM (2010) Pharmacological interventions for fertility preservation during chemotherapy: a systematic review and meta-analysis. Breast Cancer Res Treat 122(3):803–811

    Article  Google Scholar 

  11. Moore HCF, Unger JM, Phillips K-A et al (2015) Goserelin for ovarian protection during breast-cancer adjuvant chemotherapy. N Engl J Med 372:923–932

    Article  CAS  Google Scholar 

  12. Lambertini M, Moore HCF, Robert CF et al (2018) Gonadotropin-releasing hormone agonists during chemotherapy for preservation of ovarian function and fertility in premenopausal patients with early breast cancer: a systematic review and meta-analysis of individual patient-level data. J Clin Oncol 36:1981–1990

    Article  CAS  Google Scholar 

  13. Chen H, Xiao L, Li J, Cui L, Huang W (2019) Adjuvant gonadotropin-releasing hormone analogues for the prevention of chemotherapy-induced premature ovarian failure in premenopausal women. Cochrane Database Syst Rev 3:CD008018

    PubMed  Google Scholar 

  14. Blumenfeld Z, Zur H, Dann EJ (2015) Gonadotropin-releasing hormone agonist cotreatment during chemotherapy may increase pregnancy rate in survivors. Oncologist 20(11):1283–1289

    Article  CAS  Google Scholar 

  15. Askanase AD, Buyon JP (2002) Reproductive health in SLE. Best Pract Res Clin Rheumatol 16:265–280

    Article  Google Scholar 

  16. Bellver J, Pellicer A (2009) Ovarian stimulation for ovulation induction and in vitro fertilization in patients with systemic lupus erythematosus and antiphospholipid syndrome. Fertil Steril 92(6):1803–1810

    Article  Google Scholar 

  17. Meirow D, Levron J, Eldar-Geva T et al (2005) Pregnancy after transplantation of cryopreserved ovarian tissue in a patient with ovarian failure after chemotherapy. N Engl J Med 353:318–321

    Article  CAS  Google Scholar 

  18. Oktay K, Cil AP, Bang H (2006) Efficiency of oocytes cryopreservation: a meta-analysis. Fertil Steril 86:70–80

    Article  Google Scholar 

  19. Chian RC, Huang JY, Gilbert L et al (2009) Obstetric outcomes following vitrification of in vitro and in vivo matured oocytes. Fertil Steril 91(6):2391–2398

    Article  Google Scholar 

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Arora, A. (2020). Fertility Preservation in Women with Autoimmune Diseases Treated with Gonadotoxic Agents. In: Sharma, S. (eds) Women's Health in Autoimmune Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-15-0114-2_9

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  • DOI: https://doi.org/10.1007/978-981-15-0114-2_9

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-15-0113-5

  • Online ISBN: 978-981-15-0114-2

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