Skip to main content
SpringerLink
Log in

Autoantibodies in Pregnancy

  • Chapter
  • First Online:
Women's Health in Autoimmune Diseases

  • 428 Accesses

Abstract

Autoantibodies are immunoglobulins with specificity against self-antigens due to the presence of autoreactive T and B lymphocytes. Pregnancy is complicated by many diseases and vice versa. Various antibodies in mother during pregnancy are involved in maternal-fetal interactions, and the levels of various circulating antibodies in pregnancy may play a crucial role in the outcome of pregnancy, intrauterine fetal death or stillbirth, intrauterine growth restriction, pre-term birth, and so on. This chapter gives a brief review of the most commonly detected antibodies in pregnancy.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Yang X, Zhang C, Chen G, Sun C, Li J (2019) Antibodies: the major participants in maternal-fetal interaction. J Obstet Gynaecol Res 45(1):39–46

    PubMed  Google Scholar 

  2. Panaitescu AM, Nicolaides K (2018) Maternal autoimmune disorders and fetal defects. J Matern-Fetal Neonatal Med 31(13):1798–1806

    CAS  PubMed  Google Scholar 

  3. Sakthiswary R, Rajalingam S, Norazman MR, Hussein H (2015) Antinuclear antibodies predict a higher number of pregnancy loss in unexplained recurrent pregnancy loss. Clin Ter 166(2):e98–e101

    CAS  PubMed  Google Scholar 

  4. Hefler-Frischmuth K, Walch K, Hefler L, Tempfer C, Grimm C (2017) Serologic markers of autoimmunity in women with recurrent pregnancy loss. Am J Reprod Immunol 77(4). https://doi.org/10.1111/aji.12635

  5. Ticconi C, Pietropolli A, Borelli B, Bruno V, Piccione E, Bernardini S et al (2016) Antinuclear autoantibodies and pregnancy outcome in women with unexplained recurrent miscarriage. Am J Reprod Immunol 76(5):396–399

    CAS  PubMed  Google Scholar 

  6. Cubillos J, Lucena A, Lucena C, Mendoza JC, Ruiz H, Arango A et al (1997) Incidence of autoantibodies in the infertile population. Early Pregnancy 3(2):119–124

    CAS  PubMed  Google Scholar 

  7. Shoenfeld Y, Carp HJA, Molina V, Blank M, Cervera R, Balasch J et al (2006) Autoantibodies and prediction of reproductive failure. Am J Reprod Immunol 56(5–6):337–344

    CAS  PubMed  Google Scholar 

  8. Tonello M, Hoxha A, Mattia E, Zambon A, Visentin S, Cerutti A et al (2017) Low titer, isolated anti Ro/SSA 60 kd antibodies is correlated with positive pregnancy outcomes in women at risk of congenital heart block. Clin Rheumatol 36(5):1155–1160

    PubMed  Google Scholar 

  9. Meena A, Nagar P (2016) Pregnancy outcome in euthyroid women with anti-thyroid peroxidase antibodies. J Obstet Gynaecol India 66(3):160–165

    CAS  PubMed  Google Scholar 

  10. De Carolis C, Greco E, Guarino MD, Perricone C, Dal Lago A, Giacomelli R et al (2004) Anti-thyroid antibodies and antiphospholipid syndrome: evidence of reduced fecundity and of poor pregnancy outcome in recurrent spontaneous aborters. Am J Reprod Immunol 52(4):263–266

    PubMed  Google Scholar 

  11. Zhang SC, Wang SW, Zhao XD, Zhang JR (2016) [Obstetrical complications of thyroid peroxidase antibody positive during pregnancy and effects of intervention: a meta-analysis]. Zhonghua Fu Chan KeZaZhi 51(4):250–257

    Google Scholar 

  12. Chen L-M, Zhang Q, Si G-X, Chen Q-S, Ye E, Yu L-C et al (2015) Associations between thyroid autoantibody status and abnormal pregnancy outcomes in euthyroid women. Endocrine 48(3):924–928

    CAS  PubMed  Google Scholar 

  13. Matalon ST, Blank M, Ornoy A, Shoenfeld Y (2001) The association between anti-thyroid antibodies and pregnancy loss. Am J Reprod Immunol 45(2):72–77

    CAS  PubMed  Google Scholar 

  14. Nazarpour S, Ramezani Tehrani F, Simbar M, Azizi F (2016) Thyroid autoantibodies and the effect on pregnancy outcomes. J Obstet Gynaecol 36(1):3–9

    CAS  PubMed  Google Scholar 

  15. Inagaki J, Matsuura E, Nomizu M, Sugiura-Ogasawara M, Katano K, Kaihara K et al (2001) IgG anti-laminin-1 autoantibody and recurrent miscarriages. Am J Reprod Immunol 45(4):232–238

    CAS  PubMed  Google Scholar 

  16. Matalon ST, Blank M, Matsuura E, Inagaki J, Nomizu M, Levi Y et al (2003) Immunization of naïve mice with mouse laminin-1 affected pregnancy outcome in a mouse model. Am J Reprod Immunol 50(2):159–165

    PubMed  Google Scholar 

  17. Davies M, Browne CM (1985) Anti-trophoblast antibody responses during normal human pregnancy. J Reprod Immunol 7(4):285–297

    CAS  PubMed  Google Scholar 

  18. Tedesco F, Pausa M, Nardon E, Narchi G, Bulla R, Livi C et al (1997) Prevalence and biological effects of anti-trophoblast and anti-endothelial cell antibodies in patients with recurrent spontaneous abortions. Am J Reprod Immunol 38(3):205–211

    CAS  PubMed  Google Scholar 

  19. Power DA, Mather AJ, MacLeod AM, Lind T, Catto GR (1986) Maternal antibodies to paternal B-lymphocytes in normal and abnormal pregnancy. Am J Reprod Immunol Microbiol 10(1):10–13

    CAS  PubMed  Google Scholar 

  20. Wendel K, Akkök ÇA, Kutzsche S (2017) Neonatal alloimmune thrombocytopaenia associated with maternal HLA antibodies. BMJ Case Rep 2017. https://doi.org/10.1136/bcr-2016-218269

  21. Lee J, Romero R, Xu Y, Miranda J, Yoo W, Chaemsaithong P et al (2013) Detection of anti-HLA antibodies in maternal blood in the second trimester to identify patients at risk of antibody-mediated maternal anti-fetal rejection and spontaneous preterm delivery. Am J Reprod Immunol 70(2):162–175

    CAS  PubMed  PubMed Central  Google Scholar 

  22. Meuleman T, Haasnoot GW, van Lith JMM, Verduijn W, Bloemenkamp KWM, Claas FHJ (2018) Paternal HLA-C is a risk factor in unexplained recurrent miscarriage. Am J Reprod Immunol 79(2). https://doi.org/10.1111/aji.12797

  23. Petty RE, Sherry DD, Johannson J (1985) Anti-IgA antibodies in pregnancy. N Engl J Med 313(26):1620–1625

    CAS  PubMed  Google Scholar 

  24. Katz JA (2004) Pregnancy and inflammatory bowel disease. Curr Opin Gastroenterol 20(4):328–332

    PubMed  Google Scholar 

  25. Eksteen M, Heide G, Tiller H, Zhou Y, Nedberg NH, Martinez-Zubiaurre I et al (2017) Anti-human platelet antigen (HPA)-1a antibodies may affect trophoblast functions crucial for placental development: a laboratory study using an in vitro model. Reprod Biol Endocrinol 15(1):28

    PubMed  PubMed Central  Google Scholar 

  26. Ousmane C, Makhtar BEH, Fatoumata B, Massi GD, Lémine DSM, Soda D-SM et al (2016) Polymyositis anti-SRP antibodies and pregnancy about 2 cases. Pan Afr Med J 24:192

    PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh, India

    Gummadi Anjani & Amit Rawat

Authors
  1. Gummadi Anjani
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Amit Rawat
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Internal Medicine, PGIMER, Chandigarh, India

    Shefali Khanna Sharma

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Anjani, G., Rawat, A. (2020). Autoantibodies in Pregnancy. In: Sharma, S. (eds) Women's Health in Autoimmune Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-15-0114-2_4

Download citation

  • DOI: https://doi.org/10.1007/978-981-15-0114-2_4

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-15-0113-5

  • Online ISBN: 978-981-15-0114-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation