Abstract
Complete heart block is a rare disease encountered in 1 in 15,000 births. It is mostly seen in babies with structurally normal heart, and its strong association with maternal anti-Ro/SSA and anti-La/SSB antibodies has been established. Once diagnosed, management include insertion of a permanent pacemaker in neonatal period which has shown to have excellent outcomes. Other therapies include in utero corticosteroids administration which may be considered for incomplete varieties in early gestational period.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Michaelsson M, Riesenfeld T, Jonzon A (1997) Natural history of congenital complete atrioventricular block. Pacing Clin Electrophysiol 20(8 Pt 2):2098–2101
Yater WM (1929) Congenital heart-block: review of the literature; report of a case with incomplete heterotaxy; the electrocardiogram in dextrocardia. Am J Dis Child 38(1):112–136
Pregnancy outcomes in patients with autoimmune diseases and anti-Ro/SSA antibodies [cited 15 May 2019]. Available from https://www.ncbi.nlm.nih.gov/pubmed/20012231
Buyon JP, Hiebert R, Copel J, Craft J, Friedman D, Katholi M et al (1998) Autoimmune-associated congenital heart block: demographics, mortality, morbidity and recurrence rates obtained from a National Neonatal Lupus Registry. J Am Coll Cardiol 31(7):1658–1666
Brucato A, Frassi M, Franceschini F, Cimaz R, Faden D, Pisoni MP et al (2001) Risk of congenital complete heart block in newborns of mothers with anti-Ro/SSA antibodies detected by counter immunoelectrophoresis: a prospective study of 100 women. Arthritis Rheum 44(8):1832–1835
Cardiac manifestations of neonatal lupus: a review of autoantibody associated congenital heart block and its impact in an adult population [cited 13 May 2019]. Available from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3275696/
McCune AB. Maternal and fetal outcome in neonatal lupus erythematosus [cited 13 May 2019]. Available from https://scholar.google.com/scholar_lookup?title=Maternal%20and%20fetal%20outcome%20in%20neonatal%20lupus%20erythematosus&publication_year=1987&author=A.B.%20McCune&author=W.L.%20Weston&author=L.A.%20Lee
Brito-Zerón P, Izmirly P, Ramos-Casals M, Buyon J, Khamashta M (2016) Autoimmune congenital heart block: complex and unusual situations. Lupus 25(2):116–128
Rein AJJT, O’Donnell C, Geva T, Nir A, Perles Z, Hashimoto I et al (2002) Use of tissue velocity imaging in the diagnosis of fetal cardiac arrhythmias. Circulation 106(14):1827–1833
Saleeb S, Copel J, Friedman D, Buyon JP (1999) Comparison of treatment with fluorinated glucocorticoids to the natural history of autoantibody-associated congenital heart block: retrospective review of the research registry for neonatal lupus. Arthritis Rheum 42(11):2335–2345
Jaeggi ET, Fouron J-C, Silverman ED, Ryan G, Smallhorn J, Hornberger LK (2004) Transplacental fetal treatment improves the outcome of prenatally diagnosed complete atrioventricular block without structural heart disease. Circulation 110(12):1542–1548
Ciardulli A, D’Antonio F, Magro-Malosso ER, Saccone G, Manzoli L, Radolec M et al (2019) Maternal steroid therapy for fetuses with immune-mediated complete atrioventricular block: a systematic review and meta-analysis. J Matern Fetal Neonatal Med 32(11):1884–1892
Cuneo BF, Lee M, Roberson D, Niksch A, Ovadia M, Parilla BV et al (2010) A management strategy for fetal immune-mediated atrioventricular block. J Matern Fetal Neonatal Med 23(12):1400–1405
Epstein AE, DiMarco JP, Ellenbogen KA, Estes NA, Freedman RA et al (2008) ACC/AHA/HRS 2008 guidelines for device-based therapy of cardiac rhythm abnormalities. Circulation 117(21):e350–e408
Robledo-Nolasco R, Ortiz-Avalos M, Rodriguez-Diez G, Jimenez-Carrillo C, RamÃrez-Machuca J, De Haro S et al (2009) Transvenous pacing in children weighing less than 10 kilograms. Pacing Clin Electrophysiol 32(Suppl 1):S177–S181
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Barwad, P., Uppal, L. (2020). Management of Neonate with Heart Block. In: Sharma, S. (eds) Women's Health in Autoimmune Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-15-0114-2_22
Download citation
DOI: https://doi.org/10.1007/978-981-15-0114-2_22
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-15-0113-5
Online ISBN: 978-981-15-0114-2
eBook Packages: MedicineMedicine (R0)