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Protective Effect of Marine Peptides/Toxins in CVD Using Zebrafish Model

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Zebrafish: A Model for Marine Peptide Based Drug Screening

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Abstract

Diseases occurring in heart or blood vessels are known as cardiovascular diseases (CVDs). Myocardial infarction and angina are commonly known as heart attack, and they are also known as coronary artery diseases (CADs). Other CVDs include stroke, heart failure, hypertensive, rheumatic heart diseases, cardiomyopathy, heart arrhythmia, congenital heart disease, alular heart disease, carditis, aortic aneurysms, peripheral artery disease, thromboembolic disease and venous thrombosis. About 90% of CVDs are preventable. CVD can be prevented by good eating habit, regular exercise, avoiding tobacco and smoke and limited alcohol intake. The zebrafish (Danio rerio) is an excellent model for studies of CVD and CAD. Bioactive macromolecules derived from marine materials and biopeptides are enhance our health promotion and reduces diseases risk. This chapter reveals that marine peptides could be used as an antihypertensive agent, and that the zebrafish provides an alternative in vivo model to efficiently evaluate the antihypertensive properties of marine peptides.

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Acknowledgement

The support provided by the Department of Biotechnology, Ministry of Science and Technology, Government of India (To Dr. Senthilkumar Rajagopal – No: BT/RLF/Reentry/42/2012) to complete this chapter in a successful manner is gratefully acknowledged.

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Authors and Affiliations

  1. Native Medicine and Marine Pharmacology Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education (Deemed to be a University), Kelambakkam, Tamil Nadu, India

    Saravanan Ramachandran

  2. Department of Biochemistry, Rayalaseema University, Kurnool, Andhra Pradesh, India

    Senthilkumar Rajagopal

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  1. Saravanan Ramachandran
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  2. Senthilkumar Rajagopal
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Ramachandran, S., Rajagopal, S. (2019). Protective Effect of Marine Peptides/Toxins in CVD Using Zebrafish Model. In: Zebrafish: A Model for Marine Peptide Based Drug Screening. Springer, Singapore. https://doi.org/10.1007/978-981-13-7844-7_5

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