Abstract
Peptides transfer the information from cell to cell and regulate the life which is involved in biological signalling mechanism. Peptides consist of a combination of two or more amino acids which are linked together to form a polypeptide. Peptides are unable to enter into the cell since they are water soluble molecule. The DNA receives the peptide’s signal through the membrane receptor and these peptides are important bioactive natural products. Based on peptide’s broad spectrum bioactivites, these peptides have high medicinal and are present in many marine species and they have high potential nutritional and medicinal values. The divergence activities of these marine peptides fascinated towards the consideration of the pharmaceutical industry, which endeavours to intention them for use in the remedy or anticipation of various diseases. Various marine peptides and their derivatives have high cost-effective values and had reached the pharmaceutical and nutraceutical perseverance.
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References
Agyei D, Danquah K (2011) Industrial-scale manufacturing of pharmaceutical-grade bioactive peptides. Biotechnol Adv 29:272–277
Barzideh Z, A L, CY G, Benjakul S, Karim A (2014) Isolation and characterisation of collagen from the ribbon jellyfish (Chrysaora sp.). Int J Food Sci Technol 49:1490–1499
Brogden K, Guthmiller J, Salzet M, Zasloff M (2005) The nervous system and innate immunity: the neuropeptide connection. Nat Immunol 6:558–564
Byun H, Kim S (2001) Purification and characterization of angiotensin I converting enzyme (ACE) inhibitory peptides from Alaska pollack (Theragrachalcogramma) skin. Process Biochem 36:1155–1162
Casewell N, Wuster W, Vonk F, Harrison R, Fry B (2013) Complex cocktails: the evolutionary novelty of venoms. Trends Ecol Eval 28:219–229
Chakrabarti S, Guha S, Majumder K (2018) Food-derived bioactive peptides in human health: challenges and opportunities. Nutrients 10:1738
Conceicao K, Konno K, Melo R, Marques E, Hiruma-Lima C, Lima C, Richardson M, Pimenta D, Lopes-Ferreira M (2006) Orpotrin: a novel vasoconstrictor peptide from the venom of the Brazilian sting ray Potamotrygong orbignyi. Peptides 27:3039–3046
Craik D, Daly N, Saska I, Trabi M, Johan Rosengren K (2003) Structures of naturally occurring circular proteins from bacteria. J Bacteriol 185:4011–4021
De Vries D, Beart P (1995) Fishing for drugs from the sea: status and strategies. Tredens Pharmacol Sci 16:275–279
Dias D, Urban S, Roessner U (2012) Historical overview of natural products in drug discovery. Meta 2:303–336
Di-Bernardini R, Harnedy P, Bolton D, Kerry J, O’Neill E, Mullen A, Hayes M (2011) Antioxidant and antimicrobial peptidichydrolysates from muscle protein sources and by-products. Food Chem 124:1296–1307
Felician F, Xia C, Qi W, Xu H (2018) Collagen from marine biological sources and medical applications. Chem Biodivers 15:e1700557
Ghadessy F, Chen D, Kini R, Chung M, Jeyaseelan K, Khoo H, Yuen R (1996) Stonustoxin is a novel lethal factor from stonefish (Synanceja horrida) venom cDNA cloning and characterization. J Biol Chem 271:25575–25581
Hancock R (2001) Cationic peptides: effectors in innate immunity and novel antimicrobials. Lancet Infect Dis 1:156–164
Hartmann R, Meisel H (2007) Food-derived peptides with biological activity: from research to food applications. Curr Opin Biotechnol 18:163–169
Kamdem J, Tsopmo A (2017) Reactivity of peptides within the food matrix. J Food Biochem:e12489
Kim S, Mendis E (2006) Bioactive compounds from marine processing byproducts—a review. Food Res Int 39:383–393
Kinch M, Haynesworth A, Kinch S, Hoyer D (2014) An overview of FDA-approved new molecular entities: 1827–2013. Drug Discov Today 19:1033–1039
King G (2011) Venoms as a platform for human drugs: translating toxins into therapeutics. Expert Opin Biol Ther 11:1469–1484
Kitts D, Weiler K (2003) Bioactive proteins and peptides from food sources. Applications of bioprocesses used in isolation and recovery. Curr Pharm Des 9:1309–1323
Kondejewski L, Jelokhani-Niaraki M, Farmer S, Lix B, Kay C, Sykes B, Hancock R, Hodges R (1999) Dissociation of antimicrobial and hemolytic activities in cyclic peptide diastereomers by systematic alterations in amphipathicity. J Biol Chem 274:13181–13192
Lee S, Hur S (2017) Antihypertensive peptides from animal products, marine organisms, and plants. Food Chem 228:506–517
Lehrer R, Selsted M, Szklarek D, Fleischmann J (1983) Antibacterial activity of microbicidal cationic proteins 1 and 2, natural peptide antibiotics of rabbit lung macrophages. Infect Immun 42:10–14
Martins A, Vieira H, Gaspar H, Santos S (2014) Marketed marine natural products in the pharmaceutical and cosmeceutical industries: tips for success. Mar Drugs 12:1066–1101
Mayer A, Gustafson K (2008) Marine pharmacology in 2005–2006: antitumour and cytotoxic compounds. Eur J Cancer 44:2357–2387
Meyer B, Mann N, Lewis J, Milligan G, Sinclair A, Howe P (2003) Dietary intakes and food sources of omega-6 and omega-3 polyunsaturated fatty acids. Lipids 38:391–398
Minkiewicz P, Dziuba J, Michalska J (2011) Bovine meat proteins as potential precursors of biologically active peptides-a computational study based on the BIOPEP database. Food Sci Technol Int 17:39–45
Molinski T, Dalisay D, Lievens S, Saludes J (2009) Drug development from marine natural products. Nat Rev Drug Discov 8:69–85
Montaser R, Luesch H (2011) Marine natural products: A new wave of drugs? Future Med Chem 3:1475–1489
Murray B, FitzGerald R (2007) Angiotensin converting enzyme inhibitory peptides derived from food proteins: biochemistry, bioactivity and production. Curr Pharm Des 13:773–791
Nagai H (2012) Marine protein toxins. Springer, Dordretch
Nagai T, Araki Y, Suzuki N (2002) Collagen of the skin of ocellate puffer fish (Takifugu rubripes). Food Chem 78:173–177
Nagai T, Suzuki N, Tanoue Y, Kai N, Nagashima T (2010) Characterization of acid-soluble collagen from skins of surf smelt (Hypomesus pretiosus japonicus Brevoort). Food Nutr Sci 1:59–66
Naylor R (2001) ECOLOGY: aquaculture–a gateway for exotic species. Science 294:1655–1656
Newman D, Cragg G (2012) Natural products as sources of new drugs over the 30 years from 1981 to 2010. J Nat Prod 75:311–335
Nishimoto S, Goto Y, Morishige H, Shiraishi R, Doi M, Akiyama K, Yamauchi S, Sugahara T (2008) Mode of action of the immunostimulatory effect of collagen from jellyfish. Biosci Biotechnol Biochem 72:2806–2811
Padhia A, Senguptaa M, Senguptaa S, Roehmb K, Sonawane A (2014) Antimicrobial peptides and proteins in mycobacterial therapy: current status and future prospects. Tuberculosis 94:363–373
Rajapakse N, Jung W, Mendis E, Moon S, Kim S (2005) A novel anticoagulant purified from fish protein hydrolysate inhibits factor XIIa and platelet aggregation. Life Sci 76:2607–2619
Rennekamp A, Peterson R (2015) 15 years of zebrafish chemical screening. Curr Opin Chem Biol 24:58–70
Rizzello C, Tagliazucchi D, Babini E, Rutella G, Saa D, Gianotti A (2016) Bioactive peptides from vegetable food matrices: research trends and novel biotechnologies for synthesis and recovery. J Funct Foods 27:549–569
Robinson S, Safavi-Hemami H, McIntosh L, Purcell A, Norton R, Papenfuss A (2014) Diversity of Conotoxin gene Superfamilies in the venomous snail, Conus victoriae. PLoS One 9:e87648
Rosenberg A (2008) Aquaculture: the price of lice. Nature 451:23–24
Rushikesh S, Pravin P, Seetharama J (2017) Peptides, Peptidomimetics, and polypeptides from marine sources: A wealth of natural sources for pharmaceutical applications. Mar Drugs 15:124
Rustad T (2003) Utilisation of marine by-products. Electron J Environ Agric Food Technol 2:458–463
Sengupta D, Leontiadou H, Mark A, Marrink S (2008) Toroidal pores formed by antimicrobial peptides show significant disorder. Biochem Biophys Acta 1778:2308–2317
Silva T, Moreira-Silva J, Marques A, Domingues A, Bayon Y, Reis R (2014) Marine origin collagens and its potential applications. Mar Drugs 12:5881–5901
Ueda A, Suzuki M, Honma T, Nagai H, Nagashima Y, Shiomi K (2006) Purification, properties and cDNA cloning of neoverrucotoxin (neoVTX), a hemolyticlethal factor from the stonefish Synanceia verrucosa venom. Biochim Biophys Acta 1760:1713–1722
Zanetti M (2004) Cathelicidins, multifunctional peptides of the innate immunity. J Leukoc Biol 75:39–48
Zasloff M (1987) Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. Proc Natl Acad Sci U S A 84:5449–5453
Acknowledgement
Saravanan Ramachandran gratefully acknowledges the Department of Biotechnology, Ministry of Science and Technology, Government of India (BT/PR15676/AAQ/03/794/2016) for providing the facilities and financial support. Senthilkumar Rajagopal gratefully acknowledges the support provided by the Department of Biotechnology, Ministry of Science and Technology, Government of India (No: BT/RLF/Re-entry/42/2012).
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Ramachandran, S., Rajagopal, S. (2019). Biomedical Importance of Marine Peptides/Toxins. In: Zebrafish: A Model for Marine Peptide Based Drug Screening. Springer, Singapore. https://doi.org/10.1007/978-981-13-7844-7_1
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DOI: https://doi.org/10.1007/978-981-13-7844-7_1
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