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Use of Electron Spin Resonance and Spin Trapping Technique in the Studies of Tropical Parasitic Diseases

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Electron Spin Resonance Spectroscopy in Medicine

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Abstract

Electron spin resonance is a widely used technique in the studies of free radical species due to its high sensitivity. Free radicals are species that are commonly found at very low concentration. This does not allow the easy detection of this species, and the use of complementary techniques such as spin trap becomes necessary together with electron spin resonance. Spin trapping technique involves the use of a molecule called “spin trap” that reacts with the free radical to form a more stable radical called “spin adduct.” Parasitic diseases are prevalent in different continents and countries but are especially concentrated in tropical and subtropical areas. These diseases represent a major health and economic problem mainly for developing nations. There is a wide variety of antiparasitic drugs, offering various levels of structural complexity and activity. Among them, there are several drugs that act primarily by generating radical free radicals. In this chapter, we discuss the importance and applications of ESR and spin trapping technique for the study of tropical parasitic diseases.

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Authors and Affiliations

  1. Departamento de Química, Facultad de Ciencias Básicas, Universidad Metropolitana de Ciencias de la Educación, Santiago, Chile

    Germán Barriga-González

  2. Departamento de Química Inorgánica y Analítica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago, Chile

    Claudio Olea-Azar

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  1. Germán Barriga-González
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Correspondence to Claudio Olea-Azar .

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  1. Physics Department, Ewing Christian College, Allahabad, Uttar Pradesh, India

    Ashutosh Kumar Shukla

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Barriga-González, G., Olea-Azar, C. (2019). Use of Electron Spin Resonance and Spin Trapping Technique in the Studies of Tropical Parasitic Diseases. In: Shukla, A. (eds) Electron Spin Resonance Spectroscopy in Medicine. Springer, Singapore. https://doi.org/10.1007/978-981-13-2230-3_3

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