Abstract
PBM is one of the anomalous conditions in which the bile duct and the pancreatic duct merge outside the duodenal wall, which causes continuous pancreaticobiliary reflux (PR). PBM is classified into two groups as follows: PBM with biliary dilatation (congenital biliary dilatation, CBD) and PBM without dilatation. US must be the best method for the diagnosis of PBM associated with CBD, revealing extrahepatic or intrahepatic bile duct dilatation. In adults, the maximum inner diameter of extrahepatic bile duct (MDEBD) was recently reported. MDEBD positively correlated with age. In cases of PBM without bile duct dilatation, thickening of the gallbladder wall as a characteristic sonographic feature has been reported. Hyperplastic changes with increased cell proliferation in gallbladder mucosa induced by PR could reflect as thickening of the gallbladder. A high confluence of pancreaticobiliary ducts (HCPBD) has been defined as a disease state. In HCPBD cases, PR and hyperplastic changes in gallbladder were observed. US is an important image modality to give clues to the diagnosis in cases with PBM, CBD, and HCPBD, because it can reveal sonographic characteristics such as gallbladder wall thickening and/or mild dilatation of the extrahepatic bile duct.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Kamisawa T, Ando H, Suyama M, et al. Japanese clinical practice guidelines for pancreaticobiliary maljunction. J Gastroenterol. 2012;47:731–59.
Kamisawa T, Ando H, Shimada M, et al. Recent advances and problems in the management of pancreaticobiliary maljunction: feedback from the guidelines committee. J Hepatobiliary Pancreat Sci. 2014;21:87–92.
Hanada K, Itoh M, Fujii K, et al. Pathology and cellular kinetics of gallbladder with an anomalous junction of pancreaticobiliary duct. Am J Gastroenterol. 1996;91:1007–11.
Miyazaki M, Yoshitomi H, Miyakawa S, et al. Clinical practice guidelines for the management of biliary tract cancers 2015: the 2nd English edition. J Hepatobiliary Pancreat Sci. 2015;22:249–73.
Ando H, Ito T, Nagaya M, et al. Pancreaticobiliary maljunction without choledochal cyst in infants and children: clinical features and surgical therapy. J Pediatr Surg. 1995;30:1358–663.
Yamao K, Nakamura T, Suzuki T, et al. The diagnosis of pancreaticobiliary maljunction. In: Koyanagi K, Aoki T, editors. Pancreaticobiliary maljunction. Tokyo: Igakutosho; 2002. p. 39–46.
Ishibashi H, Shimada M, Kamisawa T, et al. Japanese clinical practice guidelines for congenital biliary dilatation. J Hepatobiliary Pancreat Sci. 2017;24:1–16.
Sugai M, Ishido K, Endoh M, et al. Sonographic demonstration of wall thickness of the gallbladder in pediatric patients with pancreatico-biliary maljunction. J Hepatobiliary Pancreat Sci. 2010;17:345–8.
Itoi T, Kamisawa T, Fujii H, et al. Extrahepatic bile duct measurement by using transabdominal ultrasound in Japanese adults: multi-center prospective study. J Gastroenterol. 2013;48:1045–50.
Morine Y, Shimada M, Takamatsu H, et al. Clinical features of pancreaticobiliary maljunction: update analysis of 2nd Japan-nationwide survey. J Hepato-Biliary-Pancreat Surg. 2013;20:472–80.
Kamisawa T, Kuruma S, Tabata T, et al. Pancreaticobiliary maljunction and biliary cancer. J Gastroenterol. 2015;50:273–9.
Hanada K, Tsuchida A, Kajiyama G. Cellular kinetic and gene mutations in gallbladder mucosa with an anomalous junction of pancreaticobiliary duct. J Hepato-Biliary-Pancreat Surg. 1996;6:223–8.
Hanada K, Tsuchida A, Iwao T, et al. Gene mutations of K-ras in gallbladder mucosae and gallbladder carcinoma with an anomalous junction of the pancreaticobiliary duct. Am J Gastroenterol. 1999;94:1638–42.
Nagai M, Watanabe M, Iwase T, et al. Clinical and genetic analysis of noncancerous and cancerous biliary epithelium in patients with pancreaticobiliary maljunction. World J Surg. 2002;26:91–8.
Hanada K, Itoh M, Fujii K, et al. K-ras and p35 mutations in stage I gallbladder carcinoma with an anomalous junction of the pancreaticobiliary duct. Cancer. 1996;77:452–8.
Ichikawa Y, Kamiyama M, Sekido H, et al. Telomerase activity and Bcl-2 expression in gallbladder of pancreaticobiliary maljunction patients: a preliminary study. J Hepato-Biliary-Pancreat Surg. 2004;11:34–9.
Kamisawa T, Amemiya K, Tu Y, et al. Clinical significance of a long common channel. Pancreatology. 2002;2:122–8.
Itoi T, Tsuchida A, Itokawa F, et al. Histologic and genetic analysis of the gallbladder in patients with occult pancreatobiliary reflux. Int J Mol Med. 2005;15:425–30.
Kamisawa T, Kuruma S, Chiba K, et al. Biliary carcinogenesis in pancreaticobiliary maljunction. J Gastroenterol. 2017;52:158–63.
Yamao K, Mizutani S, Nakazawa S, et al. Prospective study of the detection of anomalous connection of pancreaticobiliary ducts during routine medical exanimations. Hepato-Gastroenterology. 1996;43:1238–45.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Hanada, K., Shimizu, A., Minami, T. (2018). Role of Ultrasonography for the Diagnosis of Pancreaticobiliary Maljunction and Congenital Biliary Dilatation. In: Kamisawa, T., Ando, H. (eds) Pancreaticobiliary Maljunction and Congenital Biliary Dilatation. Springer, Singapore. https://doi.org/10.1007/978-981-10-8654-0_12
Download citation
DOI: https://doi.org/10.1007/978-981-10-8654-0_12
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-10-8653-3
Online ISBN: 978-981-10-8654-0
eBook Packages: MedicineMedicine (R0)