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Induction of Immunogenic Cell Death by Chemotherapeutic Platinum Complexes

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Rethinking Platinum Anticancer Drug Design: Towards Targeted and Immuno-chemotherapeutic Approaches

Part of the book series: Springer Theses ((Springer Theses))

Abstract

There is growing evidence that conventional chemotherapeutics can modulate the immune system and trigger an immune response which sustains a long term durable therapeutic outcome.

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Authors and Affiliations

  1. Department of Chemistry, National University of Singapore, Singapore, Singapore

    Daniel Yuan Qiang Wong

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  1. Daniel Yuan Qiang Wong
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Correspondence to Daniel Yuan Qiang Wong .

Supplementary Information

Supplementary Information

Supplementary Figures

Fig. S6.1
figure 7figure 7

Cells observed under confocal microscopy after drug treatment (4 h) and incubation with H2DCFDA (ROS indicator, green) and ER-Tracker Red (red). a CT-26. b MDA-MB-231. c Colocalisation analysis after Pt-NHC treatment (1 μM) on MDA-MB-231. White pixels indicate areas of colocalisation as determined by Costes method

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Wong, D.Y.Q. (2018). Induction of Immunogenic Cell Death by Chemotherapeutic Platinum Complexes. In: Rethinking Platinum Anticancer Drug Design: Towards Targeted and Immuno-chemotherapeutic Approaches. Springer Theses. Springer, Singapore. https://doi.org/10.1007/978-981-10-8594-9_6

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