Skip to main content
SpringerLink
Log in

Anticancer Activity of Herbal Medicine: Mechanism of Action

  • Chapter
  • First Online:
Anticancer Plants: Mechanisms and Molecular Interactions

Abstract

Cancer is an alarming disease and quite lethal in nature in developed and developing nations. Many new therapeutic agents and therapies are available in the market but have some severe side effects on human beings’ organs. These therapeutic agents are quite costly and not easily available in some of the developing nations. Various scientific reports have shown that chemoprevention through naturally derived herbal and dietary phytochemicals is an innovative therapeutic tool against different cancer types. These herbal phytochemicals have shown their potential anticancer activity in both in vitro and in vivo studies. Further, many of them have been successfully proved for their chemopreventive property by inducing apoptosis equivalent to certain other chemical drugs without causing any side effects. The combinational role of herbal and dietary phytochemicals has proved to be very effective against cancer prevention. The present chapter summarised the effectiveness of herbal and dietary phytochemicals for chemoprevention and also highlighted their combinational role on various kinds of cancer.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Afshari JT, Brook A, Mousavi SH (2008) Study of cytotoxic and apoptogenic properties of saffron extract in human cancer cell lines. Food Chem Toxicol 46:3443–3447

    Article  CAS  Google Scholar 

  • Aggarwal S, Takada Y, Singh S, Myers JN, Aggarwal BB (2004) Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor-kB signalling. Int J Cancer 111:679–692

    Article  PubMed  CAS  Google Scholar 

  • Amantini C, Mosca M, Nabissi M, Lucciarini R, Caprodossi S, Arcella A, Giangaspero F, Santoni G (2007) Capsaicin-induced apoptosis of glioma cells is mediated by TRPV1 vanilloid receptor and requires p38 MAPK activation. J Neurochem 102:977–990

    Article  PubMed  CAS  Google Scholar 

  • Amruthraj NJ, Preetam Raj JP, Saravanan S, Lebel LA (2014) In vitro studies on anticancer activity of capsaicinoids from capsicum Chinese against human hepatocellular carcinoma cells. Int J Pharm Pharm Sci 6:254–558

    Google Scholar 

  • Anand P, Sundaram C, Jhurani S, Kunnumakkara AB, Aggarwal BB (2008) Curcumin and cancer: an “old-age” disease with an “age-old” solution. Cancer Lett 267:133–164

    Article  PubMed  CAS  Google Scholar 

  • Araujo CC, Leon LL (2001) Biological activities of Curcuma longa L. Mem Inst Oswaldo Cruz 96:723–728

    Article  PubMed  CAS  Google Scholar 

  • Arnold JT, Wilkinson BP, Sharma S, Steele VE (1993) Evaluation of chemopreventative agents in different mechanistic classes using a rat epithelial cell culture transformation assay. Cancer Res 73:537–543

    Google Scholar 

  • Aruna SJ, Benjamin PM, Nirupama G, Satya N (2002) β-Catenin-mediated transactivation and cell-cell adhesion pathways are important in curcumin (diferuloylmethane)-induced growth arrest and apoptosis in colon cancer cells. Oncogene 21:8414–8427

    Article  CAS  Google Scholar 

  • Aung HH, Wang CZ, Ni M, Fishbein A, Mehendale SR, Xie JT (2007) Crocin from Crocus sativus possesses significant anti-proliferation effects on human colorectal cancer cells. Exp Oncol 29:175–180

    PubMed  PubMed Central  CAS  Google Scholar 

  • Bakshi H, Sam S, Rozati R (2010) DNA fragmentation and cell cycle arrest: a hallmark of apoptosis induced by crocin from Kashmiri saffron in a human pancreatic cancer cell line. Asian Pac J Cancer Prev 11:675–679

    PubMed  Google Scholar 

  • Beauregard AP, Harquail J, Claux GL, Belbraouet M, Francois JJ, Touaibia M, Robichaud GA (2015) CAPE analogs induce growth arrest and apoptosis in breast cancer cells. Molecules 20:12576–12589

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Bettuzzi S, Brausi M, Rizzi F, Castagnetti G, Peracchia G, Corti A (2006) Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof of principle study. Cancer Res 66:1234–1240

    Article  PubMed  CAS  Google Scholar 

  • Bettuzzi S, Rizzi F, Belloni L (2007) Clinical relevance of the inhibitory effect of green tea catechins (GtCs) on prostate cancer progression in combination with molecular profiling of catechin resistant tumors: an integrated view. Pol J Vet Sci 10:57–60

    PubMed  CAS  Google Scholar 

  • Bhanot A, Sharma R, Noolvi NM (2011) Natural sources as potential anti-cancer agents: a review. Int J Phytomed 3:9–26

    Google Scholar 

  • Bhardwaj A, Sethi G, Vadhan Raj S, Bueso-Ramos CE, Takada Y, Gaur U, Nair A, Shishodia S, Aggarwal B (2007) Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor kB-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells. Blood 109:2293–2302

    Article  PubMed  CAS  Google Scholar 

  • Bhatia N, Agarwal C, Agarwal R (2001) Differential responses of skin cancer-chemopreventive agents silibinin, quercetin, and epigallocatechin 3-gallate on mitogenic signaling and cell cycle regulators in human epidermoid carcinoma A431 cells. Nutr Cancer 39:292–299

    Article  PubMed  CAS  Google Scholar 

  • Bhattacharya S, Darjatmoko SR, Polans AS (2011) Resveratrol modulates the malignant properties of cutaneous melanoma via changes in the activation and attenuation of the anti-apoptotic Protooncogenic protein Akt/PKB. Melanoma Res 21:180–187

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Bhutani M, Pathak AK, Nair AS, Kunnumakkara AB, Guha S, Sethi G, Aggarwal BB (2007) Capsaicin is a novel blocker of constitutive and interleukin-6-inducible STAT3 activation. Clin Cancer Res 13:3024–3032

    Article  PubMed  CAS  Google Scholar 

  • Brown KC, Witte TR, Hardman WE, Luo H, Chen YC, Carpenter AB, Lau JK, Dasgupta P (2010) Capsaicin displays anti-proliferative activity against human small cell lung cancer in cell culture and nude mice models via the E2F pathway. PLoS One 5:e10243

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Cakir Z, Saydam G, Sahin F, Baran Y (2011) The roles of bioactive sphingolipids in resveratrol-induced apoptosis in HL60 acute myeloid leukemia cells. J Cancer Res Clin Oncol 137:279–286

    Article  PubMed  CAS  Google Scholar 

  • Cecchinato V, Chiaramonte R, Nizzardo M, Cristofaro B, Basile A, Sherbet GV, Comi P (2007) Resveratrol-induced apoptosis in human T-cell acute lymphoblastic leukemia MOLT-4 cells. Biochem Pharmacol 74:1568–1577

    Article  PubMed  CAS  Google Scholar 

  • Chang WC, Hsieh CH, Hsiao MW, Lin WC, Hung YC, Ye JC (2010) Caffeic acid induces apoptosis in human cervical cancer cells through the mitochondrial pathway. Taiwan J Obstet Gynecol 49:419–424

    Article  PubMed  Google Scholar 

  • Chen J, Dong XS, Guo XG (2009) Inhibitory effect of resveratrol on the growth of human colon cancer ls174t cells and its subcutaneously transplanted tumor in nude mice and the mechanism of action. Zhonghua Zhong Liu Za Zhi 31:15–95

    PubMed  Google Scholar 

  • Chen JC, Lu KW, Lee JH, Yeh CC, Chung JG (2006) Gypenosides induced apoptosis in human colon cancer cells through the mitochondria-dependent pathways and activation of caspase-3. Anticancer Res 26:4313–4326

    PubMed  CAS  Google Scholar 

  • Chen WF, Huang MH, Tzang CH, Yang M, Wong MS (2003) Inhibitory actions of genistein in human breast cancer (MCF-7) cells. Biochim Biophys Acta 1638:187–196

    Article  PubMed  CAS  Google Scholar 

  • Cheng AC, Lee MF, Tsai ML, Lai CS, Lee JH, Ho CT, Pan MH (2011) Rosmanol potently induces apoptosis through both the mitochondrial apoptotic pathway and death receptor pathway in human colon adenocarcinoma COLO 205 cells. Food Chem Toxicol 49:485–493

    Article  PubMed  CAS  Google Scholar 

  • Chou CC, Wu YC, Wang YF, Chou MJ, Kuo SJ, Chen DR (2009) Capsaicin-induced apoptosis in human breast cancer MCF-7 cells through caspase-independent pathway. Oncol Rep 21:665–671

    PubMed  CAS  Google Scholar 

  • Chryssanthi DG, Dedes PG, Karamanos NK, Cordopatis P, Lamari FN (2011) Crocetin inhibits invasiveness of MDA-MB-231 breast cancer cells via downregulation of matrix metalloproteinases. Planta Med 77:146–151

    Article  PubMed  CAS  Google Scholar 

  • Chryssanthi DG, Lamari FN, Iatrou G, Pylara A, Karamanos NK, Cordopatis P (2007) Inhibition of breast cancer cell proliferation by style constituents of different Crocus species. Anticancer Res 27:357–362

    PubMed  CAS  Google Scholar 

  • Collett GP, Campbell FC (2004) Curcumin induces c-jun N-terminal kinase-dependent apoptosis in HCT116 human colon cancer cells. Carcinogenesis 25:2183–2189

    Article  PubMed  CAS  Google Scholar 

  • Coradini D, Pellizzaro C, Marimpietri D, Abolafio G, Daidone MG (2000) Sodium butyrate modulates cell cycle-related proteins in HT29 human colonic adenocarcinoma cells. Cell Prolif 33:139–146

    Article  PubMed  CAS  Google Scholar 

  • Cragg GM, Newman DJ (2009) Natural product scaffolds as leads to drugs. Future Med Chem 1:1415–1427

    Article  PubMed  Google Scholar 

  • Cui X, Jin Y, Hofseth AB, Pena E, Habiger J, Chumanevich A, Poudyal D, Nagarkatti M, Nagarkatti PS, Singh UP, Hofsetha LJ (2010) Resveratrol suppresses colitis and colon cancer associated with colitis. Cancer Prev Res 3:549–559

    Article  CAS  Google Scholar 

  • Damle AA, Pawar YP, Narkar AA (2013) Anticancer activity of betulinic acid on MCF-7 tumors in nude mice. Indian J Exp Biol 51:485–491

    PubMed  CAS  Google Scholar 

  • Deliliers LG, Servida G, Fracchiolla NS, Ricci C, Borsotti C, Colombo G, Soligo D (2002) Effects of inositol hexaphosphate (IP6) on human normal and leukaemic hematopoietic cells. Br J Haematol 117:577–587

    Article  PubMed  CAS  Google Scholar 

  • Demain AL, Vaishnav P (2011) Natural products for cancer chemotherapy. Microb Biotechnol 4:687–699

    Article  PubMed  PubMed Central  Google Scholar 

  • Dhar A, Mehta S, Dhar G, Dhar K, Banerjee S, Van Veldhuizen P, Campbell DR, Banerjee SK (2009) Crocetin inhibits pancreatic cancer cell proliferation and tumor progression in a xenograft mice model. Mol Cancer Ther 8:315–323

    Article  PubMed  CAS  Google Scholar 

  • Diaka JK, Oseni SO, Famuyiwa T, Branly R (2015) Therapeutic impact of vitamin C on the anticancer activities of Genistein isoflavone in radiosensitized Lncap prostate cancer cells. J Cancer Prev Curr Res 2:1–7

    Google Scholar 

  • D’Incalci M, Steward WP, Gescher AP (2005) Use of cancer chemopreventive phytochemicals as antineoplastic agents. Lancet Oncol 6:899–904

    Article  PubMed  CAS  Google Scholar 

  • Du GJ, Wang CZ, Qi LW, Zhang ZY, Calway T, He TC, Du W, Yuan CS (2013) The synergistic apoptotic interaction of panaxadiol and epigallocatechin gallate in human colorectal cancer cells. Phytother Res 27:272–277

    Article  PubMed  CAS  Google Scholar 

  • Dutta D, Sarkar A, Chakraborty B, Chowdhury C, Das P (2015) Induction of apoptosis by a potent Betulinic acid derivative in Human colon carcinoma HT-29 cells. Int J Sci Res Publ 5:1–5

    Google Scholar 

  • Eguchi D, Ikenaga N, Ohuchida K, Kozono S, Cui L, Fujiwara K, Fujino M, Ohtsuka T, Mizumoto K, Tanaka M (2013) Hypoxia enhances the interaction between pancreatic stellate cells and cancer cells via increased secretion of connective tissue growth factor. J Surg Res 181:225–233

    Article  PubMed  CAS  Google Scholar 

  • Elattar TM, Virji AS (2000) The inhibitory effect of curcumin, genistein, quercetin and cisplatin on the growth of oral cancer cells in vitro. Anticancer Res 20:1733–1738

    PubMed  CAS  Google Scholar 

  • Escribano J, Alonso GL, Coca-Prados M, Fernandez A (1996) Crocin, safranal and picocrocin from saffron (Crocus sativus L.) inhibit the growth of human cancer cells in vitro. Cancer Lett 100:23–30

    Article  PubMed  CAS  Google Scholar 

  • Fatlawi AAA, Irshad M, Zafaryab M, Rizvi MM, Ahmad A (2014) Anticarcinogenic activity of rice bran phytic acid against human breast cancer cell line (MCF-7). Asian J Pharm Clin Res 7:151–155

    Google Scholar 

  • Follo-Martinez AD, Banerjee N, Li X, Safe S, Mertens-Talcott S (2013) Resveratrol and quercetin in combination have anticancer activity in colon cancer cells and repress oncogenic microRNA-27a. Nutr Cancer 65:494–504

    Article  PubMed  CAS  Google Scholar 

  • Fouad MA, Agha AM, Al Merzabani MM, Shouman SA (2013) Resveratrol inhibits proliferation, angiogenesis and induces apoptosis in colon cancer cells: calorie restriction is the force to the cytotoxicity. Hum Exp Toxicol 32:1067–1080

    Article  PubMed  CAS  Google Scholar 

  • Fujiki H, Suganuma M (2012) Green tea: an effective synergist with anticancer drugs for tertiary cancer prevention. Cancer Lett 324:119–125

    Article  PubMed  CAS  Google Scholar 

  • Galicia IL, Chavez JD, Villa EG, Figueroa LU, Miranda AH, Herrera LA, Rios EA, Mena JG, Gariglio P (2013) Resveratrol induces downregulation of DNA repair genes in MCF-7 human breast cancer cells. Eur J Cancer Prev 22:11–20

    Article  CAS  Google Scholar 

  • George J, Singh M, Srivastava AK, Bhui K, Roy P, Chaturvedi PK, Shukla Y (2011) Resveratrol and black tea polyphenol combination synergistically suppress mouse skin tumors growth by inhibition of activated MAPKs and p53. PLoS One 6:e23395

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Gokbulut AA, Apohan E, Baran Y (2013) Resveratrol and quercetin-induced apoptosis of human 232B4 chronic lymphocytic leukaemia cells by activation of caspase-3 and cell cycle arrest. Hematology 18:144–150

    Article  PubMed  CAS  Google Scholar 

  • Golkar L, Ding XZ, Ujiki MB, Salabat MR, Kelly DL, Scholtens D, Fought AJ, Bentrem DJ, Talamonti MS, Bell RH, Adrian TE (2007) Resveratrol inhibits pancreatic cancer cell proliferation through transcriptional induction of macrophage inhibitory cytokine-1. J Surg Res 138:163–169

    Article  PubMed  CAS  Google Scholar 

  • Govindarajan VS, Sathyanarayana MN (1991) Capsicum-production, technology, chemistry, and quality. Part V. Impact on physiology, pharmacology, nutrition, and metabolism; structure, pungency, pain, and desensitization sequences. Crit Rev Food Sci Nutr 29:435–474

    Article  PubMed  CAS  Google Scholar 

  • Guerrero IC, Andres LS, Leon LG, Machin RP, Padron JM, Luis JG, Delgadillo J (2006) Abietane diterpenoids from Salvia pachyphylla and S. clevelandii with cytotoxic activity against human cancer cell lines. J Nat Prod 69:1803–1805

    Article  CAS  PubMed  Google Scholar 

  • Gutheil WG, Reed G, Ray A, Anant S, Dhar A (2012) Crocetin: an agent derived from saffron for prevention and therapy for cancer. Curr Pharm Biotechnol 13:173–179

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Hail NJ, Lotan R (2002) Examining the role of mitochondrial respiration in vanilloid-induced apoptosis. J Natl Cancer Inst 94:1281–1292

    Article  PubMed  CAS  Google Scholar 

  • Hanif R, Qiao L, Schiff SJ, Rigas B (1997) Curcumin, a natural plant phenolic food additive, inhibits cell proliferation and induces cell cycle changes in colon adenocarcinoma cell lines by a prostaglandin-independent pathway. J Lab Clin Med 130:576–584

    Article  PubMed  CAS  Google Scholar 

  • Hermann RM, Wolff HA, Jarry H, Thelen P, Gruendker C, Rave-Fraenk M, Schmidberger H, Christiansen H (2008) In vitro studies on the modification of low-dose hyper-radiosensitivity in prostate cancer cells by incubation with genistein and estradiol. Radiat Oncol 3:19. https://doi.org/10.1186/1748-717X-3-19

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Ho YC, Yang SF, Peng CY, Chou MY, Chang YC (2007) Epigallocatechin-3-gallate inhibits the invasion of human oral cancer cells and decreases the productions of matrix metalloproteinases and urokinase-plasminogen activator. J Oral Pathol Med 36:588–593

    Article  PubMed  CAS  Google Scholar 

  • Hong J, Kim MR, Lee NH, Lee BH (2009) Inhibition of oral epithelial cell growth in vitro by epigallocatechin-3-gallate; its modulation by serum and antioxidant enzymes. Food Sci Biotechnol 18:971–977

    CAS  Google Scholar 

  • Hsieh TC, Wu JM (2008) Suppression of cell proliferation and gene expression by combinatorial synergy of EGCG, resveratrol and gamma-tocotrienol in estrogen receptor-positive MCF-7 breast cancer cells. Int J Oncol 33:851–859

    PubMed  CAS  Google Scholar 

  • Huang SP, Chen JC, Wu CC, Chen CT, Tang NY, Ho YT, Lo C, Lin JP, Chung JG, Lin JG (2009) Capsaicin-induced apoptosis in human hepatoma HepG2 cells. Anticancer Res 29:165–174

    PubMed  CAS  Google Scholar 

  • Huang TT, Lin HC, Chen CC, Lu CC, Wei CF, Wu TS, Liu FG, Lai HC (2011) Resveratrol induces apoptosis of human nasopharyngeal carcinoma cells via activation of multiple apoptotic pathways. J Cell Physiol 226:720–728

    Article  PubMed  CAS  Google Scholar 

  • Huh SW, Bae SM, Kim YW, Lee JM, Namkoong SE, Lee IP, Kim SH, Kim CK, Ahn WS (2004) Anticancer effects of (−)-epigallocatechin-3-gallate on ovarian carcinoma cell lines. Gynecol Oncol 94:760–768

    Article  PubMed  CAS  Google Scholar 

  • Husna SN, Norhaizan ME, Hairuszah I, Abdah MA, Norazalina S, Norsharina I (2010) Rice bran phytic acid (IP6) induces growth inhibition, cell cycle arrest and apoptosis on human colorectal adenocarcinoma cells. J Med Plant Res 4:2283–2289

    Google Scholar 

  • Hussein A, Meyer J, Jimeno M, Rodríguez B (2007) Bioactive diterpenes from Orthosiphon labiatus and Salvia africana-lutea. J Nat Prod 70:293–295

    Article  PubMed  CAS  Google Scholar 

  • Hwang JT, Kwak DW, Lin SK, Kim HM, Kim YM, Park OJ (2007) Resveratrol induces apoptosis in chemo-resistant cancer cells via modulation of AMPK signalling pathway. Ann N Y Acad Sci 1095:441–448

    Article  PubMed  CAS  Google Scholar 

  • Ip SW, Lan SH, Huang AC, Yang JS, Chen YY, Huang HY, Lin ZP, Hsu YM, Yang MD, Chiu CF, Chung JG (2012a) Capsaicin induces apoptosis in SCC-4 human tongue cancer cells through mitochondria dependent and independent pathways. Environ Toxicol 27:332–341

    Article  PubMed  CAS  Google Scholar 

  • Ip SW, Lan SH, Lu HF, Huang AC, Yang JS, Lin JP, Huang HY, Lien JC, Ho CC, Chiu CF, Wood W, Chung JG (2012b) Capsaicin mediates apoptosis in human nasopharyngeal carcinoma NPC-TW 039 cells through mitochondrial depolarization and endoplasmic reticulum stress. Hum Exp Toxicol 31:539–549

    Article  PubMed  CAS  Google Scholar 

  • Ito K, Nakazato T, Yamato K, Miyakawa Y, Yamada T, Hozumi N, Segawa K, Ikeda Y, Kizaki M (2004) Induction of apoptosis in leukemic cells by homovanillic acid derivative, capsaicin, through oxidative stress: implication of phosphorylation of p53 at Ser-15 residue by reactive oxygen species. Cancer Res 64:1071–1078

    Article  PubMed  CAS  Google Scholar 

  • Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D (2011) Global cancer statistics. CA Cancer J Clin 61:60–90

    Article  Google Scholar 

  • Ji SJ, Han DH, Kim JH (2006) Inhibition of proliferation and induction of apoptosis by EGCG in human osteogenic sarcoma (HOS) cells. Arch Pharm Res 29:363–368

    Article  PubMed  CAS  Google Scholar 

  • Jin J, Lin G, Huang H, Xu D, Yu H, Ma X, Zhu L, Ma D, Jiang H (2014) Capsaicin mediates cell cycle arrest and apoptosis in human colon cancer cells via stabilizing and activating p53. Int J Biol Sci 10:285–295

    Article  PubMed  PubMed Central  Google Scholar 

  • Johnson J (2011) Carnosol: a promising anti-cancer and anti-inflammatory agent. Cancer Lett 305:1–7

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Johnson J, Syed D, Heren C, Suh Y, Adhami V, Mukhtar H (2008) Carnosol, a dietary diterpene, displays growth inhibitory effects in human prostate cancer PC3 cells leading to G2-phase cell cycle arrest and targets the 50-AMP-activated protein kinase (AMPK) pathway. Pharm Res 25:2125–2134

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Johnson JJ, Bailey HH, Mukhtar H (2010) Green tea polyphenols for prostate cancer chemo-prevention: a translational perspective. Phytomedicine 17:3–13

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Jung MY, Kang HJ, Moon A (2001) Capsaicin-induced apoptosis in SK-Hep-1 hepatocarcinoma cells involves Bcl-2 down regulation and caspase-3 activation. Cancer Lett 165:139–145

    Article  PubMed  CAS  Google Scholar 

  • Kartal M, Saydam G, Sahin F, Baran Y (2011) Resveratrol triggers apoptosis through regulating ceramide metabolizing genes in human K562 chronic myeloid leukemia cells. Nutr Cancer 63:637–644

    Article  PubMed  CAS  Google Scholar 

  • Kato K, Long NK, Makita H, Toida M, Yamashita T, Hatakeyama D, Hara A, Mori H, Shibata T (2008) Effects of green tea polyphenol on methylation status of RECK gene and cancer cell invasion in oral squamous cell carcinoma cells. Br J Cancer 99:647–654

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Kawamori T, Lubet R, Steele VE, Kelloff GJ, Kaskey RB, Rao CV, Reddy BS (1999) Chemopreventive effect of curcumin, a naturally occurring anti-inflammatory agent during the promoting/progression stages of colon cancer. Cancer Res 59:597–601

    PubMed  CAS  Google Scholar 

  • Kim CJ, Cho YG, Park CH, Kim SY, Nam SW, Lee SH, Yoo NJ, Lee JY, Park WS (2004) Genetic alterations of the MYH gene in gastric cancer. Oncogene 23:6820–6822

    Article  PubMed  CAS  Google Scholar 

  • Kunnumakkara AB, Guha S, Krishnan S, Diagaradjane P, Gelovani J, Aggarwal BB (2007) Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor kappa B-regulated gene products. Cancer Res 67:3853–3861

    Article  PubMed  CAS  Google Scholar 

  • Lambert JD, Elias RJ (2010) The antioxidant and pro-oxidant activities of green tea polyphenols: a role in cancer prevention. Arch Biochem Biophys 501:65–72

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Lambertini E, Piva R, Khan MT, Lampronti I, Bianchi N, Borgatti M, Gambari R (2004) Effects of extracts from Bangladeshi medicinal plants on in vitro proliferation of human breast cancer cell lines and expression of estrogen receptor alpha gene. Int J Oncol 24:419–423

    PubMed  Google Scholar 

  • Lampe JW, Nishino Y, Ray RM, Wu C, Li W, Lin MG, Gao DL, Hu Y, Shannon J, Stalsberg H, Porter PL, Frankenfeld CL, Wahala K, Thomas DB (2007) Plasma isoflavones and fibrocystic breast conditions and breast cancer among women in Shanghai, China. Cancer Epidemiol Biomark Prev 16:2579–2586

    Article  CAS  Google Scholar 

  • Langroodi FA, Ghahestani ZH, Alibolandi M, Ebrahimian M, Hashemi M (2016) Evaluation of the effect of crocetin on antitumor activity of doxorubicin encapsulated in PLGA nanoparticles. Nanomed J 3:23–34

    CAS  Google Scholar 

  • Lee YS, Nam DH, Kim JA (2000) Induction of apoptosis by capsaicin in A172 human glioblastoma cells. Cancer Lett 161:121–130

    Article  PubMed  CAS  Google Scholar 

  • Lev-Ari S, Maimon Y, Strier L, Kazanov D, Arber N (2006) Down-regulation of prostaglandin E2 by curcumin is correlated with inhibition of cell growth and induction of apoptosis in human colon carcinoma cell lines. J Soc Integr Oncol 4:21–26

    PubMed  Google Scholar 

  • Liao HF, Chen YY, Liu JJ, Hsu ML, Shieh HJ, Liao HJ, Shieh CJ, Shiao MS, Chen YJ (2003) Inhibitory effect of caffeic acid phenethyl ester on angiogenesis, tumor invasion, and metastasis. J Agric Food Chem 51:7907–7912

    Article  PubMed  CAS  Google Scholar 

  • Lin CH, Lu WC, Wang CW, Chan YC, Chen MK (2013) Capsaicin induces cell cycle arrest and apoptosis in human KB cancer cells. BMC Complement Altern Med 13:46–54

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Lin YG, Kunnumakkara AB, Nair A, Merritt WM, Han LY, Armaiz-Pena GN, Kamat AA, Spannuth WA, Gershenson DM, Lutgendorf SK, Aggarwal BB, Sood AK (2007) Curcumin inhibits tumor growth and angiogenesis in ovarian carcinoma by targeting the nuclear factor-kappaB pathway. Clin Cancer Res 13:3423–3430

    Article  PubMed  CAS  Google Scholar 

  • Liu WZ, Wang ZF (2004) Accumulation and localization of camptothecin in young shoot of Camptotheca acuminata. J Plant Physiol Mol Biol 30:405–412

    CAS  Google Scholar 

  • Lo AH, Liang YC, Shiau SYL, Ho CT, Lin JK (2002) Carnosol, an antioxidant in rosemary, suppresses inducible nitric oxide synthase through down regulating nuclear factor–kB in mouse macrophages. Carcinogenesis 23:983–991

    Article  PubMed  CAS  Google Scholar 

  • Looi CY, Arya A, Cheah FK, Muharram B, Leong KH, Mohamad K, Wong WF, Rai N, Mustafa MR (2013) Induction of apoptosis in human breast cancer cells via caspase pathway by vernodalin isolated from Centratherum anthelminticum (L.) seeds. PLoS One 8:e56643. https://doi.org/10.1371/journal.pone.0056643

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • LoTempio MM, Veena MS, Steele HL, Ramamurthy B, Ramalingam TS, Cohen AN, Chakrabarti R, Srivatsan ES, Wang MB (2005) Curcumin suppresses growth of head and neck squamous cell carcinoma. Clin Cancer Res 11:6994–7002

    Article  PubMed  CAS  Google Scholar 

  • Lucie F (2000) Biological effects of resveratol. Life Sci 66:663–673

    Article  Google Scholar 

  • Lu HF, Chen YL, Yang JS, Yang YY, Liu JY, Hsu SC, Lai KC, Chung JG (2010b) Antitumor activity of capsaicin on human colon cancer cells in vitro and Colo 205 tumor xenografts in vivo. J Agric Food Chem 58:12999–13005

    Article  PubMed  CAS  Google Scholar 

  • Lu KW, Chen JC, Lai TY, Yang JS, Weng SW, Ma YS, Lu PJ, Weng JR, Chueh FS, Wood WG, Chung JG (2010a) Gypenosides inhibits migration and invasion of human oral cancer SAS cells through the inhibition of matrix metalloproteinase-2 -9 and urokinase-plasminogen by ERK1/2 and NF-kappa B signaling pathways. Hum Exp Toxicol 30:406–415

    Article  PubMed  CAS  Google Scholar 

  • Luo FJ, Hu Z, Deng XY, Zhao Y, Zeng L, Dong ZG, Yi W, Cao Y (2001) Effect of tea polyphenols and EGCG on nasopharyngeal carcinoma cell proliferation and the mechanisms involved. Chin J Cancer Res 13:235–242

    Article  CAS  Google Scholar 

  • Masamune A, Hamada S, Kikuta K, Takikawa T, Miura S, Nakano E, Shimosegawa T (2013) The angiotensin II type I receptor blocker olmesartan inhibits the growth of pancreatic cancer by targeting stellate cell activities in mice. Scand J Gastroenterol 48:602–609

    Article  PubMed  CAS  Google Scholar 

  • Mazzanti G, Ippolito FM, Moro PA, Cassetti F, Raschetti R, Santuccio C, Mastrangelo S (2009) Hepatotoxicity from green tea: a review of the literature and two unpublished cases. Eur J Clin Pharmacol 65:331–341

    Article  PubMed  Google Scholar 

  • Mceleny K, Coffey R, Morrissey C, Fitzpatrick JM, Watson RW (2004) Caffeic acid phenethyl ester-induced PC-3 cell apoptosis is caspase-dependent and mediated through the loss of inhibitors of apoptosis proteins. BJU Int 94:402–406

    Article  PubMed  CAS  Google Scholar 

  • Mengoni E, Vichera G, Rigano L, Rodriguez-Puebla M, Galliano S, Cafferata EE, Pivetta OH, Moreno S, Vojnov AA (2011) Suppression of COX-2, IL-1 and TNF-α expression and leukocyte infiltration in inflamed skin by bioactive compounds from Rosmarinus officinalis L. Fitoterapia 82:414–421

    Article  PubMed  CAS  Google Scholar 

  • Milacic V, Banerjee S, Landis-Piwowar KR, Sarkar FH, Majumdar AP, Dou QP (2008) Curcumin inhibits the proteasome activity in human colon cancer cells in vitro and in vivo. Cancer Res 68:7283–7292

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Mileshkin L, Rischin D, Prince H, Zalcberg J (2005) The contribution of cytotoxic chemotherapy to the management of cancer. Clin Oncol 17:294. https://doi.org/10.1016/j.clon.2005.02.012

    Article  CAS  Google Scholar 

  • Mori A, Lehmann S, O’Kelly J, Kumagai T, Desmond JC, Pervan M, McBride WH, Kizaki M, Koeffler HP (2006) Capsaicin, a component of red peppers, inhibits the growth of androgen-independent, p53 mutant prostate cancer cells. Cancer Res 66:3222–3229

    Article  CAS  PubMed  Google Scholar 

  • Mukhopadhyay A, Bueso-Ramos C, Chatterjee D, Pantazis P, Aggarwal BB (2001) Curcumin downregulates cell survival mechanisms in human prostate cancer cell lines. Oncogene 20:7597–7609

    Article  PubMed  CAS  Google Scholar 

  • Nakazato T, Ito K, Ikeda Y, Kizaki M (2005) Green tea component, catechin, induces apoptosis of human malignant B cells via production of reactive oxygen species. Clin Cancer Res 11:6040–6049

    Article  PubMed  CAS  Google Scholar 

  • Nguyen AV, Martinez M, Stamos MJ, Moyer MP, Planutis K, Hope C, Holcombe1 RF (2009) Results of a phase I pilot clinical trial examining the effect of plant-derived resveratrol and grape powder on Wnt pathway target gene expression in colonic mucosa and colon cancer. Cancer Manag Res 1:25–37

    Google Scholar 

  • Norazalina S, Norhaizan ME, Hairuszah I, Sabariah AR, Husna SN, Norsharina I (2011) Antiproliferation and apoptosis induction of phytic acid in hepatocellular carcinoma (HEPG2) cell lines. Afr J Biotechnol 10:16646–16653

    Google Scholar 

  • Pan L, Chai H, Kinghorn AD (2010) The continuing search for antitumor agents from higher plants. Phytochem Lett 3:1–8

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Papoutsis AJ, Lamore SD, Wondrak GT, Selmin OI, Romagnolo DF (2010) Resveratrol prevents epigenetic silencing of BRCA-1 by the aromatic hydrocarbon receptor in human breast cancer cells. J Nutr 140:1607–1614

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Parasramka MA, Gupta SV (2012) Synergistic effect of garcinol and curcumin on antiproliferative and apoptotic activity in pancreatic cancer cells. J Oncol:709739. https://doi.org/10.1155/2012/709739

  • Paschka AG, Butler R, Young CYF (1998) Induction of apoptosis in prostate cancer cell lines by green tea component, (−)-epigallocatechin-3-gallate. Cancer Lett 130:1–7

    Article  PubMed  CAS  Google Scholar 

  • Patel KR, Brown VA, Jones DJL, Britton RG, Hemingway D, Miller AS, West KP, Booth TD, Perloff M, Crowell JA, Brenner DE, Steward WP, Gescher AJ, Brown K (2010) Clinical pharmacology of resveratrol and its metabolite in colorectal cancer patient. Cancer Res 70:7392–7399

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Phillip CJ, Giardina CK, Bilir B, Cutler DJ, Lai YH, Kucuk O, Moreno CS (2012) Genistein cooperates with the histone deacetylase inhibitor vorinostat to induce cell death in prostate cancer cells. BMC Cancer 12:1–11

    Article  CAS  Google Scholar 

  • Pirouzpanah MB, Sabzichi M, Pirouzpanah S, Chavoshi H, Samadi N (2015) Silibinin-induces apoptosis in breast cancer cells by modulating p53, p21, Bak and Bcl-XL pathways. Asian Pac J Cancer Prev 16:2087–2092

    Article  PubMed  Google Scholar 

  • Podhorecka M, Halicka D, Klimek P, Kowal M, Chocholska S, Dmoszynska A (2011) Resveratrol increases rate of apoptosis caused by purine analogues in malignant lymphocytes of chronic lymphocytic leukaemia. Ann Hematol 90:173–183

    Article  PubMed  CAS  Google Scholar 

  • Pramanik KC, Boreddy SR, Srivastava SK (2011) Role of mitochondrial electron transport chain complexes in capsaicin mediated oxidative stress leading to apoptosis in pancreatic cancer cells. PLoS One 6:e20151

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Rao CV, Rivenson A, Simi B, Reddy BS (1995) Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound. Cancer Res 55:259–266

    PubMed  CAS  Google Scholar 

  • Rouholamini SEY, Motamed N, Birjandian E, Azad T, Omidfar K (2015) Inhibition of mir-15a gene expression by silibinin in MCF-7 breast cancer cell line. Int J Curr Res Aca Rev 3:288–296

    CAS  Google Scholar 

  • Russo M, Tedesco I, Iacomino G, Palumbo R, Galano G, Russo GL (2005) Dietary phytochemicals in chemoprevention of cancer. Curr Med Chem Immunol Endocr Metab Agents 5:61–72

    Article  CAS  Google Scholar 

  • Sakamoto Y, Terashitaa N, Muraguchia T, Fukusatob T, Kubota S (2013) Effects of Epigallocatechin-3-gallate (EGCG) on A549 lung cancer tumor growth and angiogenesis. Biosci Biotechnol Biochem 77:1799–1803

    Article  PubMed  CAS  Google Scholar 

  • Sakuma S, Maruyama C, Kohda T, Fujimo Y (2014) Curcumin inhibits the proliferation of a human colorectal cancer cell line Caco-2 partially by both apoptosis and G2/M cell cycle arrest. Inter J Pharmacol Res 4:84–90

    CAS  Google Scholar 

  • Samarghandian S, Shabestari MM (2013) DNA fragmentation and apoptosis induced by safranal in human prostate cancer cell line. Indian J Urol 29:177–183

    Article  PubMed  PubMed Central  Google Scholar 

  • Sánchez AM, Cazenave SM, Olea N, Vara D, Chiloeches A, Laviada ID (2007) Apoptosis induced by capsaicin in prostate PC-3 cells involves ceramide accumulation, neutral sphingomyelinase, and JNK activation. Apoptosis 12:2013–2024

    Article  CAS  PubMed  Google Scholar 

  • Santandreu FM, Valle A, Oliver J, Roca P (2011) Resveratrol potentiates the cytotoxic oxidative stress induced by chemotherapy in human colon cancer cells. Cell Physiol Biochem 28:219–228

    Article  PubMed  CAS  Google Scholar 

  • Shamsuddin AM, Baten A, Lalwani ND (1992) Effect of inositol hexaphosphate on growth and differentiation in K562 erythroleukemia cell line. Cancer Lett 64:195–202

    Article  PubMed  CAS  Google Scholar 

  • Shamsuddin AM, Yang GY (1995) Inositol hexaphosphate inhibits growth and induces differentiation of PC-3 human prostate cancer cells. Carcinogenesis 16:1975–1979

    Article  PubMed  CAS  Google Scholar 

  • Sheth S, Jajoo S, Kaur T, Mukherjea D, Sheehan K, Rybak LP, Ramkumar V (2012) Resveratrol reduces prostate cancer growth and metastasis by inhibiting the Akt/MicroRNA-21 pathway. PLoS One 7:e51655

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Shigeoka Y, Igishi T, Matsumoto S, Nakanishi H, Kodanim, Yasuda K, Hitsuda Y, Shimizu E (2004) Sulindac sulfide and caffeic acid phenethyl ester suppress the motility of lung adenocarcinoma cells promoted by transforming growth factor-beta through Akt inhibition. J Cancer Res Clin Oncol 130:146–152

    Article  PubMed  CAS  Google Scholar 

  • Siddiqui IA, Malik A, Adhami VM, Asim M, Hafeez BB, Sarfaraz S, Mukhtar H (2008) Green tea polyphenol EGCG sensitizes human prostate carcinoma LNCaP cells to TRAIL-mediated apoptosis and synergistically inhibits biomarkers associated with angiogenesis and metastasis. Oncogene 27:2055–2063

    Article  PubMed  CAS  Google Scholar 

  • Singh RP, Agarwal C, Agarwal R (2003) Inositol hexaphosphate inhibits growth, and induces G1 arrest and apoptotic death of prostate carcinoma DU145: modulation of CDKICDK-cyclin and pRb-related protein-E2F complexes. Carcinogenesis 24:555–563

    Article  PubMed  CAS  Google Scholar 

  • Singh RP, Agarwal R (2006) Mechanisms of action of novel agents for prostate cancer chemoprevention. Endoc Relat Cancer 13:751–778

    Article  CAS  Google Scholar 

  • Singh RP, Agarwal R (2009) Cosmeceuticals and silibinin. Clin Dermatol 27:479–484

    Article  PubMed  PubMed Central  Google Scholar 

  • Sivanantham B, Sethuraman S, Krishnan UM (2015) Combinatorial effects of curcumin with an anti-neoplastic agent on head and neck squamous cell carcinoma through the regulation of EGFR-ERK1/2 and apoptotic signaling pathways. ACS Comb Sci 18:22–35

    Article  PubMed  CAS  Google Scholar 

  • Siwak DR, Shishodia S, Aggarwal BB, Kuzrock R (2005) Curcumin-induced antiproliferative and proapoptotic effects in melanoma cells are associated with suppression of IkappaB kinase and nuclear factor kappaB activity and are independent of the B-Raf/mitogen-activated/extracellular signal-regulated protein kinase pathway and the Akt pathway. Cancer 104:879–890

    Article  PubMed  CAS  Google Scholar 

  • Sporn MB, Suh N (2002) Chemoprevention: an essential approach to controlling cancer. Nat Rev Cancer 2:537–543

    Article  PubMed  CAS  Google Scholar 

  • Su JL, Yang CY, Zhao M, Kuo ML, Yen ML (2007) Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. J Biol Chem 282:19385–19398

    Article  PubMed  CAS  Google Scholar 

  • Sun C, Hu Y, Liu X, Wu T, Wang Y, He W, Wei W (2006) Resveratrol downregulates the constitutional activation of nuclear factor-kB in multiple myeloma cells, leading to suppression of proliferation and invasion, arrest of cell cycle, and induction of apoptosis. Cancer Genet Cytogenet 165:9–19

    Article  PubMed  CAS  Google Scholar 

  • Surh YJ (2003) Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer 3:768–780

    Article  PubMed  CAS  Google Scholar 

  • Szallasi A, Blumberg PM (1999) Vanilloid (capsaicin) receptors and mechanisms. Pharmacol Rev 51:159–212

    PubMed  CAS  Google Scholar 

  • Tang HT, Shih A, Cao J, Davis FB, Davis PL, Lin HY (2006a) Resveratrol induced cyclooxygenase-2 apoptosis in human breast cancer cells. Mol Cancer Ther 5:2034–2042

    Article  PubMed  CAS  Google Scholar 

  • Tahara H, Sato K, Yamazaki Y, Ohyama T, Horiguchi N, Hashizume H, Kakizaki S, Takagi H, Ozaki I, Arai H, Hirato J, Jesenofsky R, Masamune A, Mori M (2013) Transforming growth factor-a activates pancreatic stellate cells and may be involved in matrix metalloproteinase-1 upregulation. Lab Investig 93:720–732

    Article  PubMed  CAS  Google Scholar 

  • Tang HT, Shih A, Cao J, Davis FB, Davis PL, Lin HY (2006b) Resveratrol induced cyclooxygenase-2 apoptosis in human breast cancer cells. Mol Cancer Ther 5:2034–2042

    Article  PubMed  CAS  Google Scholar 

  • Trincheri NF, Nicotra G, Follo C, Castino R, Isidoro C (2007) Resveratrol induces cell death in colorectal cancer cells by a novel pathway involving lysosomal cathepsin D. Arcinogenesis 28:922–931

    Article  CAS  Google Scholar 

  • Tsou MF, Lu HF, Chen SC, Wu LT, Chen YS, Kuo HM, Lin SS, Chung JG (2006) Involvement of Bax, Bcl-2, Ca2+ and caspase-3 in capsaicin-induced apoptosis of human leukemia HL-60 cells. Anticancer Res 26:1965–1971

    PubMed  CAS  Google Scholar 

  • Tsui KC, Chiang TH, Wang JS, Lin LJ, Chao WC, Chen BH, Lu JF (2014) Flavonoids from Gynostemma pentaphyllum exhibit differential induction of cell cycle arrest in H460 and A549 cancer cells. Molecules 16:17663–17681. https://doi.org/10.3390/molecules191117663

    Article  CAS  Google Scholar 

  • Tyagi A, Gu M, Takahata T, Frederick B, Agarwal C, Siriwardana S, Agarwal R, Sclafani RA (2011) Resveratrol selectively induces DNA damage, independent of Smad 4 expression, in its efficacy against human head and neck squamous cell carcinoma. Clin Cancer Res 17:5402–5411

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Van Ginkel PR, Sareen D, Subramanian L, Walker Q, Darjatmoko SR, Lindstrom MJ, Kulkarni A, Albert DM, Polans AS (2007) Resveratrol inhibits tumor growth of human neuroblastoma and mediates apoptosis by directly targeting mitochondria. Clin Cancer Res 13:5162–5169

    Article  PubMed  CAS  Google Scholar 

  • Vanamala J, Reddivari L, Radhakrishnan S, Tarver C (2010) Resveratrol suppresses IGF-1 induced human colon cancer cell proliferation and elevates apoptosis via suppression of IGF-1R/Wnt and activation of p53 signalling pathways. BMC Cancer 10:238–252

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Vorobiof DA, Abratt R (2007) The cancer burden in Africa. S Afr Med J 97:937–939

    PubMed  CAS  Google Scholar 

  • Wang D, Veena MS, Stevenson K, Tang C, Ho B, Suh JD, Duarte VM, Faull KF, Mehta K, Srivatsan ES, Wang MB (2008) Liposome-encapsulated curcumin suppresses growth of head and neck squamous cell carcinoma in vitro and in xenografts through the inhibition of nuclear factor kappaB by an AKT-independent pathway. Clin Cancer Res 14:6228–6236

    Article  PubMed  CAS  Google Scholar 

  • Wang TTY, Schoene NW, Kim YS, Mizuno CS, Rimando AM (2010) Differential effects of resveratrol and its naturally occurring methyl ether analogs on cell cycle and apoptosis in human androgen responsive LNCaP cancer cells. Mol Nutr Food Res 54:335–344

    Article  PubMed  CAS  Google Scholar 

  • Wang Y, Catana F, Yang Y, Roderick R, van Breemen RB (2002) An LC-MS method for analyzing total resveratrol in grape juice, cranberry juice, and in wine. J Agric Food Chem 50:431–435

    Article  PubMed  CAS  Google Scholar 

  • Wang Y, Wang H, Zhang W, Shao C, Xu P, Shi CH, Shi JG, Li YM, Fu Q, Xue W, Lei YH, Gao JY, Wang JY, Gao XP, Li JQ, Yuan JL, Zhang YT (2013) Genistein sensitizes bladder cancer cells to HCPT treatment in vitro and in vivo via ATM/NF-κB/IKK pathway-induced apoptosis. PLoS One 8:e50175. https://doi.org/10.1371/journal.pone.0050175

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Wu CC, Lin JP, Yang JS, Chou ST, Chen SC, Lin YT, Lin HL, Chung JG (2006) Capsaicin induced cell cycle arrest and apoptosis in human oesophagus epidermoid carcinoma CE 81 T/VGH cells through the elevation of intracellular reactive oxygen species and Ca2+ productions and caspase-3 activation. Mutat Res 601:71–82

    Article  PubMed  CAS  Google Scholar 

  • Yagiz K, Wu LY, Kuntz CP, James Morre D, Morre DM (2007) Mouse embryonic fibroblast cells from transgenic mice overexpressing tNOX exhibit an altered growth and drug response phenotype. J Cell Biochem 101:295–306

    Article  PubMed  CAS  Google Scholar 

  • Yamamoto T, Digumarthi H, Aranbayeva Z, Wataha J, Lewis J, Messer R, Qin H, Dickinson D, Osaki T, Schuster GS, Hsu S (2007) EGCG-targeted p57/KIP2 reduces tumorigenicity of oral carcinoma cells: role of c-Jun N-terminal kinase. Toxicol Appl Pharmacol 224:318–325

    Article  PubMed  CAS  Google Scholar 

  • Yan M, Li G, Petiwala SM, Householter E, Johnson JJ (2015) Standardized rosemary (Rosmarinus officinalis) extract induces Nrf2/sestrin-2 pathway in colon cancer cells. J Funct Foods 13:137–147. https://doi.org/10.1016/j.jff.2014.12.038

    Article  CAS  Google Scholar 

  • Yu Z, Li W, Liu F (2004) Inhibition of proliferation and induction of apoptosis by genistein in colon cancer HT-29 cells. Cancer Lett 215:159–166

    Article  PubMed  CAS  Google Scholar 

  • Zhang J, Nagasaki M, Tanaka Y, Morikawa S (2003) Capsaicin inhibits growth of adult T-cell leukemia cells. Leuk Res 27:275–283

    Article  PubMed  CAS  Google Scholar 

  • Zhang L, Li L, Wu D, Fan J, Li X, Wu K, Wang X, He D (2008a) A novel anticancer effect of genistein: reversal of epithelial mesenchymal transition in prostate cancer cells. Acta Pharmacol Sin 29:1060–1068

    Article  PubMed  CAS  Google Scholar 

  • Zhang R, Humphreys I, Sahu RP, Shi Y, Srivastava SK (2008b) In vitro and in vivo induction of apoptosis by capsaicin in pancreatic cancer cells is mediated through ROS generation and mitochondrial death pathway. Apoptosis 13:1465–1478

    Article  PubMed  CAS  Google Scholar 

  • Zhang M, Zhou X, Zhou K (2013) Resveratrol inhibits human nasopharyngeal carcinoma cell growth via blocking pAkt/p70S6K signalling pathways. Int J Mol Med 31:621–627

    Article  PubMed  CAS  Google Scholar 

  • Zhang JY, Lin MT, Zhou MJ, Yi T, Tang YN, Tang SL, Yang ZJ, Zhao ZZ, Chen HB (2015) Combinational treatment of curcumin and quercetin against gastric cancer MGC-803 cells in vitro. Molecules 20:11524–11534

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Zhu W, Qin W, Zhang K, Rottinghaus GE, Chen YC, Kliethermes B, Sauter ER (2012) Trans-resveratrol alters mammary promoter hypermethylation in women at increased risk for breast cancer. Nutr Cancer 64:393–400

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Zunino S, Storms D (2009) Carnosol delays chemotherapy-induced DNA fragmentation and morphological changes associated with apoptosis in leukemic cells. Nutr Cancer 61:94–102

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgement

The author is thankful to Motilal Nehru National Institute of Technology (MNNIT), Allahabad, for providing the necessary facilities and also the colleagues for their generous help in preparation of the chapter.

Author information

Authors and Affiliations

  1. Department of Biotechnology, Motilal Nehru National Institute of Technology, Allahabad, Uttar Pradesh, India

    Nand Kumar Singh, Alok Kumar Yadav, Preeti Sirohi, Manjoo Rani, Saurabh Saraswat, Manish Pratap Singh, Ashutosh Mani & Sameer Srivastava

Authors
  1. Nand Kumar Singh
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Alok Kumar Yadav
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Preeti Sirohi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Manjoo Rani
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Saurabh Saraswat
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Manish Pratap Singh
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Ashutosh Mani
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Sameer Srivastava
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Nand Kumar Singh .

Editor information

Editors and Affiliations

  1. Department of Botany, Gandhi Faiz-e-Aam College, Shahjahanpur, Uttar Pradesh, India

    Mohd Sayeed Akhtar

  2. Department of Crop Science,Faculty of Agriculture, Universiti Putra Malaysia, Serdang, Selangor, Malaysia

    Mallappa Kumara Swamy

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Singh, N.K. et al. (2018). Anticancer Activity of Herbal Medicine: Mechanism of Action. In: Akhtar, M., Swamy, M. (eds) Anticancer Plants: Mechanisms and Molecular Interactions. Springer, Singapore. https://doi.org/10.1007/978-981-10-8417-1_7

Download citation

Publish with us

Policies and ethics

Search

Navigation