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Potential of Herbal Medicines in Colorectal Carcinoma and Their Mechanism of Action

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Anticancer Plants: Mechanisms and Molecular Interactions

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Abstract

Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths in the world. Although colon cancer is often treated successfully with the surgery, it requires an aggressive systemic therapy to completely cure. Several past studies have suggested the combined use of chemo- or radiotherapy with herbal medicines to enhance the efficacy and diminish the side effects caused by these therapies. In this regard, some herbal compounds such as vinca alkaloids, turmeric, astragalus, ginseng, and ginger have been well studied for their anti-colorectal cancer activities. The identification of active herbal compounds emphasizes on the development of an effective anticancer medicine, which remains as an essential step in the advanced cancer treatments. Many preclinical and clinical studies have proved that herbal medicines are safe, exhibit higher tumour suppressive activity, improve immune system, and increase sensitivity of chemo- and radiotherapeutics. The herbs are more promising as they prevent the invasion and proliferation of tumour by arresting cellular functions. Due to abundance, low cost, and safety in consumption, herbs remain with a tremendous potential to investigate as a combined formulation of chemotherapy to enable tumour growth suppression with less toxic side effect and to improve overall survival rate. The aim of the chapter is to focus on various plant and plant-derived compounds showing the promising anticancer activities against colorectal cancer and their potential mechanism of action.

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Authors and Affiliations

  1. Department of Genetics, Dr. ALM P.G. Institute of Basic Medical Sciences, University of Madras, Chennai, India

    Navina Panneerselvan

  2. Department of Medical Biochemistry, Dr. ALM P.G. Institute of Basic Medical Sciences, University of Madras, Chennai, India

    Rajeswari Ravindran

  3. Laboratory of Vaccines and Immunotherapeutics, Institute of Bioscience, Universiti Putra Malaysia, Serdang, Selangor, Malaysia

    Palanisamy Arulselvan

  4. Muthayammal Centre for Advanced Research, Muthayammal College of Arts and Science, Namakkal, Tamil Nadu, India

    Palanisamy Arulselvan

  5. Pathology Unit, Lab Based Department, Faculty of Medicine, Royal College of Medicine Perak, Universiti Kuala Lumpur, Ipoh, Perak, Malaysia

    Ravindran Jaganathan

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  1. Navina Panneerselvan
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Correspondence to Ravindran Jaganathan .

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  1. Department of Botany, Gandhi Faiz-e-Aam College, Shahjahanpur, Uttar Pradesh, India

    Mohd Sayeed Akhtar

  2. Department of Crop Science,Faculty of Agriculture, Universiti Putra Malaysia, Serdang, Selangor, Malaysia

    Mallappa Kumara Swamy

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Panneerselvan, N., Ravindran, R., Arulselvan, P., Jaganathan, R. (2018). Potential of Herbal Medicines in Colorectal Carcinoma and Their Mechanism of Action. In: Akhtar, M., Swamy, M. (eds) Anticancer Plants: Mechanisms and Molecular Interactions. Springer, Singapore. https://doi.org/10.1007/978-981-10-8417-1_3

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