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Omics: A Holistic Approach in Cancer Treatment

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Anticancer Plants: Mechanisms and Molecular Interactions

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Abstract

Omic technologies advocate a holistic approach for the biomolecules aiming at the absolute detection in any biological sample. This high-dimensional biology when integrated with bioinformatics can target the high-throughput detection and sequencing of genes, RNA, proteins, metabolites, phytochemicals, and pharmacology or their combined use. Cancer is one of the most prevalent causes of death in many countries. According to the World Health Organization, 8.2 million people worldwide in 2012 died due to cancer, and by 2035 it is expected to increase to 24 million. Anticancer drugs used are highly expensive and develop resistance with their scrupulous side effects; thus there are unprecedented efforts to uncover new treatments. With the advent of chemotherapy, omic technologies established in recent years embrace a universal view of understanding the molecular system of biomolecules. Phytochemicals like camptothecin derivatives, vinblastine, vincristine, withanolides, withaferin A, topotecan, irinotecan, etoposide, and paclitaxel (taxol) are part of the armamentarium to treat cancer. Various approaches can be used in studying molecular markers to distinguish subtypes of disease and predict mutation that aid in cancer diagnosis and prognosis. The practice of high-end emerging omic technologies, including cDNA-AFLP, SAGE, cDNA microarray, oligonucleotide microarray, and micro-RNA, can be expanded from crop plants to medicinal plants, to expedite medicinal plant breeding and transform them into subsist industries of medicinal compounds. Therefore, the aim of this chapter is to focus on developing substitutes of these therapies to treat cancer with no pain and strain to patients.

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Acknowledgments

The authors are thankful to Chairman Charutar Vidyamandal Vallabh Vidyanagar Dr. C. L. Patel for his constant support and encouragement.

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Authors and Affiliations

  1. Natubhai V. Patel College of Pure and Applied Sciences, Anand, Vallabh Vidhyanagar, Gujarat, India

    Madhumati Bora & Pratibha Parihar

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  1. Madhumati Bora
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  2. Pratibha Parihar
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Correspondence to Madhumati Bora .

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  1. Department of Botany, Gandhi Faiz-e-Aam College, Shahjahanpur, Uttar Pradesh, India

    Mohd Sayeed Akhtar

  2. Department of Crop Science,Faculty of Agriculture, Universiti Putra Malaysia, Serdang, Selangor, Malaysia

    Mallappa Kumara Swamy

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Bora, M., Parihar, P. (2018). Omics: A Holistic Approach in Cancer Treatment. In: Akhtar, M., Swamy, M. (eds) Anticancer Plants: Mechanisms and Molecular Interactions. Springer, Singapore. https://doi.org/10.1007/978-981-10-8417-1_1

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