Abstract
Homocysteinemia causes vascular wall remodelling by altering the elastin/collagen ratio and by changing the molecular characteristics of the proteoglycans, both of which are brought about by various mechanisms. Consequently, vascular compliance is altered and blood pressure increases.
Homocysteinemia is also implicated in pregnancy-induced hypertension and associated with a higher risk of complications.
Several antihypertensives like telmisartan (an angiotensin receptor blocker) and 5-aza-2′-deoxycytidine are known to reduce blood pressure by inhibiting homocysteinemia-induced vascular remodelling. Moreover, MMP-9 (its increased expression is induced by homocysteinemia) has been demonstrated to be involved in development of hypertensive cerebropathy and, hence, MMP-9 inhibitors may be used to ameliorate blood pressure as well as to help prevent cerebropathy.
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Bhargava, S. (2018). Homocysteinemia and Hypertension. In: The Clinical Application of Homocysteine. Springer, Singapore. https://doi.org/10.1007/978-981-10-7632-9_4
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DOI: https://doi.org/10.1007/978-981-10-7632-9_4
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