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Homocysteine in Occlusive Vascular Disease

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The Clinical Application of Homocysteine

Abstract

Though homocysteine was first implicated in atherothrombosis, high circulating levels of it have a myriad pathologic effects including oxidative as well as molecular mechanisms in almost all organ systems. However, this section details how homocysteinemia causes and promotes atherothrombosis, starting with the initial event of disruption of the endothelium and going on to its varied effects on the circulating lipids, platelets, the endothelial functions (proteins and factors influencing dilatation and lipid deposition), smooth muscle layer and the adventitial layer of the vessel walls.

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References

  • Abdu TA, Elhadd TA, Akber M, Hartland A, Neary R, Clayton RN. Plasma homocysteine is not a major risk factor for vascular disease in growth hormone deficient adults. Clin Endocrinol. 2001;55(5):635–8.

    Article  CAS  Google Scholar 

  • Amundsen T, Ueland PM, Waage A. Plasma homocysteine levels in patients with deep vein thrombosis. Arterioscler Thromb Vasc Biol. 1995;15:1321–3.

    Article  CAS  Google Scholar 

  • Araki A, Sako Y, Fukushima Y, Matsumoto M, Asada T, Kita T. Plasma sulfhydryl-containing amino acids in patients with cerebral infarction and in hypertensive subjects. Atherosclerosis. 1989;79:139–46.

    Article  CAS  Google Scholar 

  • Arnesen E, Refsum H, Bønaa KH, Ueland PM, Førde OH, Nordrehaug JE. Serum total homocysteine and coronary artery disease. Int J Epidemiol. 1995;24(4):704–9.

    Article  CAS  Google Scholar 

  • Baby B, Saravanan G, Chinnaswamy P. Elevated concentrations of plasma homocysteine in coronary artery disease patients with normal folate levels. J Pharm Sci Res. 2009;1(2):51–6.

    CAS  Google Scholar 

  • Basu P, Qipshidze N, Tyagi SC, Sen U. Remodelling in vein expresses arterial phenotype in homocysteinemia. Int J Physiol Pathophysiol Pharmacol. 2011;3(4):266–79.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Bayes B, Pastor MC, Bonal J, Junca J, Hernandez JM, Riutort N, Foraster A, Romero R. Homocysteine, C-reactive protein, lipid peroxidation and mortality in haemodialysis patients. Nephrol Dial Transplant. 2003;18(1):106–12.

    Article  CAS  Google Scholar 

  • Bea F, Hudson FN, Neff-Laford H, White CC, Kavanagh TJ, Kreuzer J, Preusch MR, Blessing E, Katus HA, Rosenfeld ME. Homocysteine stimulates antioxidant response element—mediated expression of glutamate-cysteine ligase in mouse macrophages. Atherosclerosis. 2009;203(1):105–11.

    Article  CAS  Google Scholar 

  • Beltowski J. Protein homocysteinylation: a new mechanism for atherogenesis? Postepy Hig Med Dosw. 2005;59:392–404.

    Google Scholar 

  • Bhargava S, Parakh R, Srivastava LM. Prevalence and treatment of homocysteinemia in occlusive vascular disease. In:Trends in clinical biochemistry and laboratory medicine. Patna: Association of Clinical Biochemists of India; 2003. p. 150–6.

    Google Scholar 

  • Bhargava S, Parakh R, Srivastava LM. Studies on homocysteine demonstrating its significance as a possible tool for differential diagnosis in occlusive vascular disease. Indian J Clin Biochem. 2004;19(1):76–8.

    Article  CAS  Google Scholar 

  • Bhargava S, Parakh R, Manocha A, Kankra M, Aggarwal CS, Menon G, Srivastava LM. High prevalence of homocysteinemia among Indian patients of vascular disease. Clin Chim Acta. 2006;374(1–2):160–2.

    Article  CAS  Google Scholar 

  • Bhargava S, Parakh R, Manocha A, Ali A, Srivastava LM. Prevalence of homocysteinemia in vascular disease: comparative study of thrombotic venous disease vis-à-vis occlusive arterial disease. Vascular. 2007;15(3):149–53.

    Article  Google Scholar 

  • Bhargava S, Ali A, Manocha A, Kankra M, Das S, Srivastava LM. Homocysteine in occlusive vascular disease: risk marker or risk factor. Indian J Biochem Biophys. 2012b;49(6):414–20.

    CAS  PubMed  Google Scholar 

  • Bhargava S, Ali A, Parakh R, Saxena R, Srivastava LM. Higher incidence of C677T polymorphism of the MTHFR gene in north Indian patients with vascular disease. Vascular. 2012c;20(2):88–95.

    Article  CAS  Google Scholar 

  • Bhargava S, Pushpakumar S, Metreveli N, Givvimani S, Tyagi SC. MMP-9 gene ablation mitigates hyperhomocystenemia-induced cognition and hearing dysfunction. Mol Biol Rep. 2014;41:4889–98.

    Article  CAS  Google Scholar 

  • Bots ML, Launer LS, Lindemans J, Hoes AW, Hofman A, Witterman JC, Koudstaal PJ, Grobbee DE. Homocysteine and short-term risk of myocardial infarction and stroke in the elderly. Arch Intern Med. 1999;159:38–44.

    Article  CAS  Google Scholar 

  • Boushey CJ, Beresford SA, Omenn GS, Motulsky AG. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease, probable benefits of folic acid intake. JAMA. 1995;274(13):1049–57.

    Article  CAS  Google Scholar 

  • Brattstrom L, Wilcken DEL. Homocysteine and cardiovascular disease: cause or effect? Am J Clin Nutr. 2000;72:315–23.

    Article  CAS  Google Scholar 

  • Brattstrom L, Lindgren A, Israelsson B, Malinow MR, Norrving B, Upson B, Hamfelt A. Homocysteinemia in stroke. Eur J Clin Investig. 1992;22:214–21.

    Article  CAS  Google Scholar 

  • Brattstrom LE, Israelsson B, Norving B, Bergqvist D, Thorme J, Hultberg B, Hamfelt A. Impaired homocysteine metabolism in early onset cerebral and peripheral occlusive arterial disease—effect of pyridoxine and folic acid treatment. Atherosclerosis. 1990;81:51–60.

    Article  CAS  Google Scholar 

  • Carson NAJ, Neill DW. Metabolic abnormalities detected in a survey of mentally backward individuals in Northern Ireland. Arch Dis Child. 1962;37:505–13.

    Article  CAS  Google Scholar 

  • Caruso R, Campolo J, Sedda V, De Chiara B, Dellanoce C, Baudo F, Tonini A, Parolini M, Cighetti G, Parodi O. Effect of homocysteine lowering by 5-methyltetrahydrofolate on redox status in homocysteinemia. J Cardiovasc Pharmacol. 2006;47(4):549–55.

    Article  CAS  Google Scholar 

  • Cavalca V, Cighetti G, Bamonta F, Loaldi A, Bortone L, Novembrino C, De Franceschi M, Belardinelli R, Guazzi MD. Oxidative stress and homocysteine in coronary artery disease. Clin Chem. 2001;47(5):887–92.

    CAS  PubMed  Google Scholar 

  • Chambers JC, Obeid OA, Refsum H, Ueland PM, Hackett D, Hooper J, Turner RM, Thompson SG, Kooner JS. Plasma homocysteine concentrations and risk of coronary heart disease in UK Indian Asian and European men. Lancet. 2000;335(9203):523–7.

    Article  Google Scholar 

  • Chandalia M, Abate N, Cabo-Chan AV Jr, Devaraj S, Jialal I, Grundy SM. Homocysteinemia in Asian Indians living in the United States. J Clin Endocrinol Metab. 2003;88(3):1089–95.

    Article  CAS  Google Scholar 

  • Chen C, Halkos ME, Surowiec SM, Conklin BS, Lin PH, Lumsden AB. Effects of homocysteine on smooth muscle cell proliferation in both cell culture and artery perfusion culture models. J Surg Res. 2000a;88(1):26–33.

    Article  CAS  Google Scholar 

  • Chen N, Liu Y, Greiner CD, Holtzman JL. Physiological concentration of homocysteine inhibit plasma GSH peroxidase which reduces organic hydroperoxides. J Lab Clin Med. 2000b;136(1):58–65.

    Article  CAS  Google Scholar 

  • Chiusolo P, Reddiconto G, Cimino G, Sica S, Fiorini A, Farina G, Vitale A, Sora F, Laurenti L, Bartolozzi F, Fazi P, Mandelli F, Leone G. Methylenetetrahydrofolate reductase genotypes do not play a role in acute lymphoblastic leukemia pathogenesis in the Italian population. Haematologica. 2004;89:139–44.

    CAS  PubMed  Google Scholar 

  • Clarke R, Daly L, Robinson K, Naughten E, Cahalane S, Fowler B, Graham J. Homocysteinemia: an independent risk factor for vascular disease. NEJM. 1991;324(17):1149–55.

    Article  CAS  Google Scholar 

  • Cyril C, Rai P, Chandra N, Gopinath PM, Satyamoorthy K. MTHFR gene variants C677T, A1298C and association with Down syndrome: a case-control study from South India. Indian J Hum Genet. 2009;15:60–4.

    Article  CAS  Google Scholar 

  • De Oliveira KC, Banco B, Verreschi ITN, Guedes AD, Galera BB, Galera MF, Barbosa CP, Lipay MVN. Prevalence of the polymorphism MTHFR A1298C and not MTHFR C677T is related to chromosomal aneuploidy in Brazilian turner syndrome patients. Arq Bras Endocrinol Metabol. 2008;52(8):1374–81.

    Article  Google Scholar 

  • Di Minno G, Davi G, Margaglione M, Cirillo F, Glandone E, Ciabattoni G, Catalona I, Strisciuglio P, Andria G, Patrono C, Mancini M. Abnormally high thromboxane biosynthesis in homozygous homocystinuria: evidence for platelet involvement and probucol-sensitive mechanism. J Clin Invest. 1993;92(3):1400–6.

    Article  Google Scholar 

  • Dissanayake VH, Weerasekera LY, Gammulla CG, Jayasekera RW. Prevalence of genetic thrombophilic polymorphisms in the Sri Lankan population–implications for association study design and clinical genetic testing services. Exp Mol Pathol. 2009;87(2):159–62.

    Article  CAS  Google Scholar 

  • Ferrazi P, Di Micco P, Quaglia I, Rossi LS, Bellatorre AG, Gaspari G, Rota LL, Lodigiani C. Homocysteine, MTHFR C677T gene polymorphism, folic acid and vitamin B12 in patients with retinal vein occlusion. Thromb J. 2005;3:13.

    Article  Google Scholar 

  • Fratoni V, Brandi ML. B vitamins, homocysteine and bone health. Forum Nutr. 2015;7:2176–92.

    CAS  Google Scholar 

  • Fujiwara Y, Mikami C, Nagai M, Yamamoto C, Hirooka T, Satoh M, Kaji T. Homocysteine inhibits proteoglycan synthesis in cultured bovine aortic smooth muscle cells. J Health Sci. 2008;54(1):56–65.

    Article  CAS  Google Scholar 

  • Gellekink H, den Heijer M, Heil SG, Blom HJ. Genetic determinants of plasma homocysteine. Semin Vasc Med. 2005;5(2):98–109.

    Article  Google Scholar 

  • Gemmati D, Ongaro A, Scapoli GL, Porta MD, Tognazzo S, Serino ML, Di Bona E, Rodeghiero F, Gilli G, Reverberi R, Caruso A, Pasello M, Pellati A, De Mattei M. Common gene polymorphisms in the metabolic folate and methylation pathway and the risk of acute lymphoblastic leukemia and non-Hodgkin’s lymphoma in adults. Cancer Epidemiol Biomark Prev. 2004;13(5):787–94.

    CAS  Google Scholar 

  • Giles WH, Croft JB, Greenland KJ, Ford ES, Kittner SJ. Association between total homocysteine and the likelihood of a history of acute myocardial infarction by race and ethnicity: results from the 3rd national health and nutrition examination survey. Am Heart J. 2000;139(3):446–53.

    Article  CAS  Google Scholar 

  • Givvimani S, Narayanan N, Armagham F, Pushpakumar S, Tyagi SC. Attenuation of vasodilation in skeletal muscle arterioles during homocysteinemia. Pharmacology. 2013;91:287–96.

    Article  CAS  Google Scholar 

  • Gupta M, Sharma P, Garg G, Kaur K, Bedi GK, Vij A. Plasma homocysteine: an independent or an interactive risk factor for coronary artery disease. Clin Chim Acta. 2005;352(1–2):121–5.

    Article  CAS  Google Scholar 

  • Harker LA, Ross R, Slitcher SA, Scott CR. Homocysteine-induced arteriosclerosis. J Clin Invest. 1974;53(3):731–41.

    Google Scholar 

  • Harpel PC, Zhang X, Borth W. Homocysteine and hemostasis:pathogenic mechanisms predisposing to thrombosis. J Nutr. 1996;126(4S):1285S–9S.

    Article  CAS  Google Scholar 

  • Hayden MR, Tyagi SC. Homocysteine and reactive oxygen species in metabolic syndrome, type 2 diabetes mellitus, and atheroscleropathy: the pleiotropic effects of folate supplementation. Nutr J. 2004;3:4–27.

    Article  Google Scholar 

  • Herrmann FH, Salazar-Sanchez L, Schroder W, Grimm R, Schuster G, Jimenez-Arce J, Chavez M, Singh JR. Prevalence of molecular risk factors FV Leiden, FV HR2, FH 20210G>A and MTHFR 677 C>T in different populations and ethnic groups of Germany Costa Rica and India. IJHG. 2001;1(1):33–9.

    Google Scholar 

  • Hill AB. The environment and disease: association or causation? Proc R Soc Med. 1965;58:295–300.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Hirsch S, Ronco AM, Vasquez M, de la Maza MP, Garrido A, Barrera G, Gattas V, Glasinovic A, Leiva L, Bunout D. Homocysteinemia in healthy young men and elderly men with normal serum folate concentration is not associated with poor vascular reactivity or oxidative stress. J Nutr. 2004;134(7):1832–5.

    Article  CAS  Google Scholar 

  • Israelsson B, Brattstorm LE, Hultberg BL. Homocysteine and myocardial infarction. Atherosclerosis. 1988;71:227–33.

    Article  CAS  Google Scholar 

  • Jakubowski H. Homocysteine thiolactone: metabolic origin and protein homocysteinylation in humans. J Nutr. 2000;130:377S–81S.

    Article  CAS  Google Scholar 

  • Jones BG, Rose FA, Tudbal N. Lipid peroxidation and homocysteine induced toxicity. Atherosclerosis. 1994;105(2):165–70.

    Article  CAS  Google Scholar 

  • Kang SS, Wong PWK, Norusis M. Homocysteinemia due to folate deficiency. Metabolism. 1987;36:458–62.

    Article  CAS  Google Scholar 

  • Kang SS, Wong PW, Malinow MR. Hyperhomocyst(e)inemia as a risk factor for occlusive vascular disease. Annu Rev Nutr. 1992;12:279–98.

    Article  CAS  Google Scholar 

  • Kartal ON, Taha S, Azzi A. Homocysteine induces DNA synthesis and proliferation of vascular smooth muscle cells by interfering with MAPK kinase pathway. Biofactors. 2005;24(1–4):193–9.

    Article  Google Scholar 

  • Katz LN, Stamler J, Pick R. Nutrition and atherosclerosis, vol. 20. Philadelphia: Lea and Febiger; 1985.

    Google Scholar 

  • Khajuria A, Houston DS. Induction of monocyte tissue factor expression by homocysteine: a possible mechanism for thrombosis. Blood. 2000;96(3):966–72.

    CAS  PubMed  Google Scholar 

  • Krajinovic M, Lamothe S, Labuda D, Lemieux-Blanchard E, Theoret Y, Moghrabi A, Sinnett D. Role of MTHFR genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia. Blood. 2004;103:252–7.

    Article  CAS  Google Scholar 

  • Kullo IJ, Bielak LF, Bailey KR, Sheedy PF, Peyser PA, Tumer ST, Kardia SL. Association of plasma homocysteine with coronary artery calcification in different categories of coronary heart disease risk. Mayo Clin Proc. 2006;81(2):177–82.

    Article  CAS  Google Scholar 

  • Kundu S, Tyagi N, Sen U, Tyagi SC. Matrix imbalance by inducing expression of metalloproteinase and oxidative stress in cochlea of hyperhomocysteinemic mice. Mol Cell Biochem. 2009;332(1–2):215–24.

    Article  CAS  Google Scholar 

  • Maldonado C, Soni CV, Todnem ND, Pushpakumar S, Rosenberger D, Givvimani S, Villafane J, Tyagi SC. Homocysteinemia and sudden cardiac death: potential arrhythmogenic mechanisms. Curr Vasc Pharmacol. 2010;8(1):64–74.

    Article  CAS  Google Scholar 

  • Malik NM, Syrris P, Schwartzman R, et al. Methylenetetrahydrofolate reductase polymorphism (C677T) and coronary artery disease. Clin Sci. 1998;95:311–5.

    Article  CAS  Google Scholar 

  • Malinow MR, Kang SS, Taylor LM, Wong PW, Coull B, Inahara T, Mukerjee D, Sexton G, Upson B. Prevalence of homocysteinemia in patients with peripheral arterial occlusive disease. Circulation. 1989;79(6):1180–8.

    Article  CAS  Google Scholar 

  • Malinow MR, Ducimetiere P, Luc G, Evans AE, Arveiler D, Cambien F, Upson BM. Plasma homocysteine levels and graded risk for myocardial infarction: findings in two populations at contrasting risk for coronary heart disease. Atherosclerosis. 1996;126:27–34.

    Article  CAS  Google Scholar 

  • Marcucci R, Brunelli T, Giusti B, Fedi S, Pepe G, Poli D, Prisco D, Abbate R, Gensini GF. The role of cysteine and homocysteine in venous and arterial thrombotic disease. Am J Clin Pathol. 2001;116(1):56–60.

    Article  CAS  Google Scholar 

  • McCully KS, Ragsdale BD. Production of arteriosclerosis by homocysteinemia. Amer J Path. 1970;61:1–11.

    CAS  PubMed  PubMed Central  Google Scholar 

  • McCully KS, Wilson RB. Homocysteine theory of arteriosclerosis. Atherosclerosis. 1975;22(2):215–27.

    Article  CAS  Google Scholar 

  • McDonald L, Bray C, Field C, Love F, Davies B. Homocysteinuria, thrombosis and blood platelets. Lancet. 1964;1:745.

    Article  CAS  Google Scholar 

  • Moller J, Rasmussen K. Homocysteine in plasma: stabilization of blood samples with fluoride. Clin Chem. 1995;41(5):758–9.

    CAS  PubMed  Google Scholar 

  • Mudd SH, Levy HL, Abeles RH. A derangement in the metabolism of vitamin B12 leading to homocystinuria, cystathioninuria and methyl malonic aciduria. Biochem Biophys Res Commun. 1969;35:121–6.

    Article  CAS  Google Scholar 

  • Mujumdar VS, Aru GM, Tyagi SC. Induction of oxidative stress by homocysteine impairs endothelial function. J Cell Biochem. 2001;82:491–500.

    Article  CAS  Google Scholar 

  • Nappo F, De Rosa N, Marfella R, De Lucia D, Ingrosso D, Perna AF, Farzati B, Giugliano D. Impairment of endothelial functions by acute homocysteinemia and reversal by antioxidant vitamins. JAMA. 1999;281(22):2113–8.

    Article  CAS  Google Scholar 

  • Nishinaga M, Ozawa T, Shimada K. Homocysteine, a thrombogenic agent, suppresses anticoagulant heparin sulfate expression in cultured porcine aortic endothelial cells. J Clin Invest. 1993;92:1381–6.

    Article  CAS  Google Scholar 

  • Nygard O, Nordrehaug JE, Refsum H, Ueland PM, Farstad M, Vollset SE. Plasma omocysteine levels and mortality in patients with coronary artery disease. N Engl J Med. 1997;337:230–7.

    Article  CAS  Google Scholar 

  • Osganian SK, Stampfer MJ, Spiegelman D, Rimm E, Cutler JA, Feldman HA, Montgomery DH, Webber LS, Lytle LA, Bausserman L, Nader PR. Distribution of and factors associated with serum homocysteine levels in children: child and adolescent trial for cardiovascular health. JAMA. 1999;281(13):1189–96.

    Article  CAS  Google Scholar 

  • Perry IJ, Refsum H, Morris RW, Ebrahim SB, Ueland PM, Shaper AG. Prospective study of serum homocysteine concentration and risk of stroke in middle-aged British men. Lancet. 1995;346:1395–8.

    Article  CAS  Google Scholar 

  • Pfanzaql B, Tribl F, Koller E, Moslinger T. Homocysteine strongly enhances metal-catalysed LDL oxidation in the presence of cysteine and cysteine. Atherosclerosis. 2003;168(1):39–48.

    Article  Google Scholar 

  • Rahbani-Nobar M, Bahrami A, Norazarian M, Dolatkhah H. Correlation between serum levels of cholesterol and homocysteine with oxidative stress in hypothyroid patients. Int J Endocrinol Metab. 2004;2:103–9.

    Google Scholar 

  • Rasouli ML, Nasir K, Blumenthal RS, Park R, Aziz DC, Budoff MJ. Plasma homocysteine predicts progression of atherosclerosis. Atherosclerosis. 2005;181(1):159–65.

    Article  CAS  Google Scholar 

  • Ratnoff OD. Activation of Hageman factor by L-homocysteine. Science. 1968;162:1007.

    Article  CAS  Google Scholar 

  • Robinson K, Mayer EL, Miller DP, Green R, van Lente F, Gupta A, Kottke-Marchant K, Savon SR, Selhub J, Nissen SE, Kutner M, Topol EJ, Jacobsen DW. Homocysteinemia and low pyridoxal phosphate. Common and independent reversible risk factors for coronary artery disease. Circulation. 1995;92:2825–30.

    Article  CAS  Google Scholar 

  • Ross R. The pathogenesis of atherosclerosis: an update. N Engl J Med. 1986;314:488–500.

    Article  CAS  Google Scholar 

  • Sadewa AH, Sutomo R, Hayashi C, Lee MJ, Ayaki H, Sofro ASM, Matsuo M, Nishio H. The C677T mutation in the methylenetetrahydrofolate reductase gene among the Indonesian Javanese population. Kobe J Med Sci. 2002;48:137–44.

    CAS  PubMed  Google Scholar 

  • Sastry BK, Indira N, Anand B, Kedarnath, Prabha BS, Raju BS. A case-control study of plasma homocysteine levels in South Indians with and without coronary artery disease. Indian Heart J. 2000; 53(6):749-53.

    Google Scholar 

  • Schimke RN, McKusick VA, Huang T, Pollack AD. Homocysteinuria: studies of 20 families and 38 affected members. JAMA. 1965;193:711–9.

    Article  CAS  Google Scholar 

  • Selhub J, Jacques PF, Bostom AG, D’Agostino RB, Wilson PWF, Belanger AJ, O’Leary DH, Wolf PA, Rush D, Schaefer EJ, Rosenberg IH. Relation between plasma homocysteine, vitamin status and extracranial carotid artery stenosis in the Framingham study population. J Nutr. 1996;126(S):1258S–65S.

    Article  CAS  Google Scholar 

  • Sen U, Moshal K, Tyagi N, Kartha GK, Tyagi SC. Homocysteine-induced myofibroblast differentiation in mouse aortic endothelial cells. J Cell Physiol. 2006;209(3):767–74.

    Article  CAS  Google Scholar 

  • Steed MM, Tyagi SC. Mechanisms of cardiovascular remodeling in homocysteinemia. Antioxid Redox Signal. 2011;15(7):1927–43.

    Article  CAS  Google Scholar 

  • Tanriverdi H, Evrengul H, Tanriverdi S, Kuru O, Seleci D, Enli Y, Kaftan A, Kilic M. Carotid intima-media thickness in coronary slow flow: relationship with plasma homocysteine levels. Cor Art Dis. 2006a;17(4):331–7.

    Article  Google Scholar 

  • Tanriverdi H, Evrengul H, Tanriverdi S, Kuru O, Seleci D, Enli Y, Kaftan A, Kilic M. Carotid intima-media thickness in coronary slow flow: relationship with plasma homocysteine levels. Coron Artery Dis. 2006b;17(4):331–7.

    Article  Google Scholar 

  • Tripathi R, Tewari S, Singh PK, Agarwal S. Association of homocysteine and methylenetetrahydrofolate reductase (MTHFR C677T) gene polymorphism with coronary artery disease (CAD) in the population of North India. Genet Mol Biol. 2010;33:224–8.

    Article  CAS  Google Scholar 

  • Tsai JC, Perrella MA, Yoshizumi M, Hsieh CM, Haber E, Schlegel R, Lee ME. Promotion of vascular smooth muscle growth by homocysteine: a link to atherosclerosis. Proc Natl Acad Sci U S A. 1994;91(14):6369–73.

    Article  CAS  Google Scholar 

  • Ubbink JB. Vitamin nutrition status and homocysteine: an atherogenic risk factor. Nutr Rev. 1994;52(11):383–7.

    Article  CAS  Google Scholar 

  • Ueland PM, Refsum H. Plasma homocysteine, a risk factor for vascular disease: plasma levels in health, disease, and drug therapy. J Lab Clin Med. 1989;114:473–501.

    CAS  PubMed  Google Scholar 

  • Veeranki S, Tyagi SC. Defective homocysteine metabolism: potential implications for skeletal muscle malfunction. Int J Mol Sci. 2013;14:15074–91.

    Article  Google Scholar 

  • Veeranki S, Gandhapudi SK, Tyagi SC. Interaction of homocysteinemia and T cell immunity in causation of hypertension. Can J Physiol Pharmacol. 2016;38:1–8.

    Google Scholar 

  • Verhoef P, Hennekens CH, Malinow MR, Kok FJ, Willet WC, Stampfer MJ. A prospective study of plasma homocysteine and risk of ischemic stroke. Stroke. 1994;25:1924–30.

    Article  CAS  Google Scholar 

  • Voutilainen S, Morrow JD, Roberts IILJ, Alfthan G, Alho H, Nyyssönen K, Salonen JT. Enhanced in vivo lipid peroxidation at elevated plasma total homocysteine levels. Arteriosclerosis Thromb Vasc Biol. 1999;19:1263–6.

    Article  CAS  Google Scholar 

  • Wald DS, Law M, Morris JK. Homocysteine and cerebrovascular disease: evidence on causality from a meta-analysis. BMJ. 2002;325(7374):1202.

    Article  Google Scholar 

  • Wald NJ, Watt HC, Law MR, Weir DG, McPartlin J, Scott JM. Homocysteine and ischaemic heart disease: results of a prospective study with implications regarding prevention. Arch Intern Med. 1998;158:862–7.

    Article  CAS  Google Scholar 

  • Wilcken B, Bamforth F, Li Z, Zhu H, Ritvanen A, Redlund M, Stoll C, Alembik Y, Dott B, Czeizel AE, Gelman-Kohan Z, Scarano G, Bianca S, Ettore G, Tenconi R, Bellato S, Scala I, Mutchinick OM, Lopez MA, de Walle H, Hofstra R, Joutchenko L, Kavteladze L, Bermejo E, Martinez-Frias ML, Gallagher M, Erickson JD, Vollset SE, Mastroiacovo P, Andria G, Botto LD. Geographic and ethnic variation of the 677C>T allele of 5,10 methylenetetrahydrofolate reductase (MTHFR): findings from over 7000 newborns from 16 areas worldwide. J Med Genet. 2003;40:619–25.

    Article  CAS  Google Scholar 

  • Wilcken DEL, Dudman NPB, Tyrell PA, Robertson MR. Folic acid lowers plasma homocysteine in chronic renal insufficiency: possible implication for prevention of vascular disease. Metabolism. 1988;37(7):697–701.

    Article  CAS  Google Scholar 

  • Wilcken DEL, Wang XL, Adachi T, Hara H, Duarte N, Green K, Wilcken B. Relationship between superoxide dismutase and homocystinuria. Arterioscler Throm Vasc Biol. 2000;20:1199–202.

    Article  CAS  Google Scholar 

  • Yang Q, Botto LD, Erickson JD, Berry RJ, Sambell C, Johansen H, Friedman JM. Improvement in stroke mortality in Canada and the United States, 1990–2002. Circulation. 2006;113(10):1335–43.

    Article  Google Scholar 

  • Yoon HJ, Jeong MH, Cho SH, Kim KH, Lee MG, Park KH, Sim DS, Yoon NS, Hong YJ, Kim JH, Ahn Y, Cho JG, Park JC, Kang JC. Endothelial dysfunction and increased carotid intima-media thickness in the patients with slow coronary flow. J Korean Med Sci. 2012;27(6):614–8.

    Article  CAS  Google Scholar 

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    Seema Bhargava (Chairperson)

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Bhargava, S. (2018). Homocysteine in Occlusive Vascular Disease. In: The Clinical Application of Homocysteine. Springer, Singapore. https://doi.org/10.1007/978-981-10-7632-9_3

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-7631-2

  • Online ISBN: 978-981-10-7632-9

  • eBook Packages: MedicineMedicine (R0)

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