Abstract
The body’s defence mechanisms are specific for each aberration in its metabolism. These function to compensate the aberration in the initial stages till the body metabolism corrects itself. When the metabolic changes cannot be compensated, pathophysiology results.
Hydrogen sulphide (H2S) is the downstream by-product of homocysteine metabolism by the transsulfuration pathway. It is the body’s defence against homocysteinemia-induced pathophysiology.
H2S is a gasotransmitter which has been shown to function as an endogenous signalling molecule which regulates a variety of physiological processes including cellular oxidative stress (especially in the blood vessel walls and renal tissue), smooth muscle relaxation (blood vessel wall and intestines), collagen synthesis and neuromodulation. It helps the body to sustain mitochondrial ATP generation in the hypoxic state as well. Thus, in the initial stages, it counters homocysteinemia-induced pathophysiology by several pathways, consequently attenuating the effects on vasculature, the brain and renal tissue especially.
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References
Abe K, Kimura H. The possible role of hydrogen sulfide as an endogenous neuromodulator. J Neurosci. 1996;16:1066–71.
Chang L, Geng B, Yu F, Zhao J, Jiang H, Du J, et al. Hydrogen sulfide inhibits myocardial injury induced by homocysteine in rats. Amino Acids. 2008;34:573–85.
Hosoki R, Matsuki N, Kimura H. The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide. Biochem Biophys Res Commun. 1997;237:527–31.
Kimura H. Hydrogen sulphide as a neuromodulator. Mol Neurobiol. 2002;26(1):13–9.
Perna AF, Ingrosso D. Low hydrogen sulphide and chronic kidney disease: a dangerous liaison. Nephrol Dial Transplant. 2012;27:486–93.
Sen U, Tyagi SC. Homocysteine and hypertension in diabetes: does PPAR have a role? PPAR Res. 2010. https://doi.org/10.1155/2010/806538.
Sen U, Herrmann M, Herrmann W, Tyagi SC. Synergism between AT1 receptor and homocysteinemia during vascular remodeling. Clin Chem Lab Med. 2007;45:1771–6.
Sen U, Basu P, Abe OA, Givvimani S, Tyagi N, Metreveli N, Shah KS, Passmore JC, Tyagi SC. Hydrogen sulphide ameliorates homocysteinemia-associated chronic renal failure. Am J Physiol Renal Physiol. 2009;297:F410–9.
Sen U, Mishra PK, Tyagi N, Tyagi SC. Homocysteine to hydrogen sulphide or hypertension. Cell Biochem Biophys. 2010a;57(2–3):49–58.
Sen U, Munjal C, Qipshidze N, Abe O, Gargoum R, Tyagi SC. Hydrogen sulphide regulates homocysteine-mediated glomerulosclerosis. Am J Nephrol. 2010b;31:442–55.
Sen U, Sathnur PB, Kundu S, Givvimani S, Coley DM, Mishra PK, Qipshidze N, Tyagi N, Metreveli N, Tyagi SC. Increased endogenous H2S generation by CBS, CSE, and 3MST gene therapy improves ex vivo renovascular relaxation in homocysteinemia. Am J Phys Cell Phys. 2012;303:C41–51.
Wang R. Two’s company, three’s a crowd—can H2S be the third endogenous gaseous transmitter? FASEB J. 2002;16:1792–8.
Yang C, Wang X, Ding H. Is coronary artery disease a multifactorial inherited disorder with a sex-influenced trait? Med Hypotheses. 2008a;71(3):449–52.
Yang G, Wu L, Jiang B, Yang W, Qi J, Cao K, Meng Q, Mustafa AK, Mu W, Zhang S, Snyder SH, Wang R. H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine γ lyase. Science. 2008b;322(5901):587–90.
Zhao W, Ndisang JF, Wang R. Modulation of endogenous production of H2S in rat tissues. Can J Physiol Pharmacol. 2003;81:848–53.
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Bhargava, S. (2018). Hydrogen Sulphide: The Body’s Inherent Defence Against Homocysteinemia. In: The Clinical Application of Homocysteine. Springer, Singapore. https://doi.org/10.1007/978-981-10-7632-9_10
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DOI: https://doi.org/10.1007/978-981-10-7632-9_10
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