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Dual-Modality Fluorescence Lifetime and Intravascular Ultrasound for Label-Free Intravascular Coronary Imaging

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Multimodality Imaging

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Abstract

Atherosclerosis in the coronary arteries accounts for nearly 50% of cardiovascular disease-related deaths. To characterize an atherosclerotic disease, imaging modalities that measure both the biochemical and structural properties of the lesions in the coronary arteries are necessary. To accomplish this, time-resolved fluorescence spectroscopy (TRFS) can be used to determine biochemical composition while adding diagnostic value to intravascular ultrasound (IVUS), which identifies structural features of the arterial wall. Healthy and diseased human arteries have distinct autofluorescent properties that allow specific biochemical features of atherosclerosis to be characterized with ultraviolet light excitation.

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Authors and Affiliations

  1. Department of Biomedical Engineering, University of California, Davis, Davis, CA, 95616, USA

    Jennifer E. Phipps, Julien Bec & Laura Marcu

Authors
  1. Jennifer E. Phipps
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  2. Julien Bec
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  3. Laura Marcu
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Corresponding author

Correspondence to Laura Marcu .

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Editors and Affiliations

  1. Department of Ophthalmology and Biomedical Engineering, University of Southern California , Los Angeles, CA, USA

    Qifa Zhou

  2. Department of Biomedical Engineering, University of California, Irvine, Irvine, CA, USA

    Zhongping Chen

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Phipps, J.E., Bec, J., Marcu, L. (2020). Dual-Modality Fluorescence Lifetime and Intravascular Ultrasound for Label-Free Intravascular Coronary Imaging. In: Zhou, Q., Chen, Z. (eds) Multimodality Imaging. Springer, Singapore. https://doi.org/10.1007/978-981-10-6307-7_6

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  • DOI: https://doi.org/10.1007/978-981-10-6307-7_6

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