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Post-translational Modifications in the Human Proteome

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Genomics and Proteomics for Clinical Discovery and Development

Part of the book series: Translational Bioinformatics ((TRBIO,volume 6))

Abstract

The Chromosome-Centric Human Proteome Project (C-HPP) is a global project aimed to identify at least one protein isoform encoded by the approximately 20, 300 human genes. In addition, protein post-translational modifications will be characterized, with the initial goal of detecting phosphorylation, acetylation, and glycosylation sites in each protein. In this chapter, we provide an overview of known post-translational modifications, their known biological functions, and present strategies to detect them on both a single protein and proteomic scales. In future proteomic studies, global characterization of post-translation modifications, splice variants, and variants caused by single nucleotide polymorphisms (SNPs) will be necessary to fully understand the role of proteins in human biology and disease.

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  1. Department of Pharmacology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, 77555, USA

    Cheryl F. Lichti, Norelle C. Wildburger, Ekaterina Mostovenko, Alexander S. Shavkunov, Shinji K. Strain & Carol L. Nilsson

  2. Department of Neuroscience and Cell Biology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, 77555, USA

    Norelle C. Wildburger

  3. Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, 77555, USA

    Mark R. Emmett

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  1. Clinical Protein Science & Imaging, Biomedical Center, Biomedical Engineering, Biomedical Center D13, Lund University, Lund, Sweden

    György Marko-Varga

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© 2014 Springer Science+Business Media Dordrecht

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Lichti, C.F. et al. (2014). Post-translational Modifications in the Human Proteome. In: Marko-Varga, G. (eds) Genomics and Proteomics for Clinical Discovery and Development. Translational Bioinformatics, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9202-8_6

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