Skip to main content

Digestion and Absorption of Other Dietary Lipids

  • Chapter
  • First Online:
The Gastrointestinal System

Abstract

The small intestine absorbs a variety of important lipids present in the diet or secreted in the bile using pathways similar to those for dietary triglycerides (Chap. 7). In this chapter, the mechanisms for absorption of cholesterol, phospholipid, bile acids, and the four fat-soluble vitamins will be reviewed. Absorption of these lipids will be considered with respect to intraluminal events, mechanisms for uptake across the brush-border membrane, metabolism within the enterocyte, and intracellular transport and secretion; the emphasis will be on the unique features of each lipid compound. In addition, the hepatic uptake and metabolism of the fat-soluble vitamins will be discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 54.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Further Reading

  1. Abumrad NA, Davidson NO (2012) Role of the gut in lipid homeostasis. Physiol Rev 92:1061–1085

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  2. Brown JM, Yu L (2010) Protein mediators of sterol transport across intestinal brush border membrane. Subcell Biochem 51:337–380

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  3. Cohn JS, Wat E, Kamili A, Tandy S (2008) Dietary phospholipids, hepatic lipid metabolism and cardiovascular disease. Curr Opin Lipidol 19:257–262

    Article  CAS  PubMed  Google Scholar 

  4. D’Ambrosio D, Clugston RD, Blaner WS (2011) Vitamin A metabolism: an uptake. Nutrients 3:62–103

    Google Scholar 

  5. Harrison E (2012) Mechanisms involved in the intestinal absorption of dietary vitamin A and provitamin A carotenoids. Biochim Biophys Acta 182:70–77

    Article  Google Scholar 

  6. Henry HL (2011) Regulation of vitamin D metabolism. Best Pract Res Clin Endocrinol Metab 25:531–541

    Article  CAS  PubMed  Google Scholar 

  7. Hofmann A (1994) Intestinal absorption of bile acid and biliary constituents. In: Johnson LR (ed) Physiology of the gastrointestinal tract, 3rd edn. Raven Press, New York, pp 1845–1865

    Google Scholar 

  8. Iqbal J, Hussain MM (2008) Intestinal lipid absorption. Am J Physiol Endocrinol Metab 296:E1183–E1194

    Article  Google Scholar 

  9. Lemair-Ewing S, Desrumaux C, Neel D, Lagrost L (2010) Vitamin E transport, membrane incorporation and cell metabolism: is α-tocopherol in lipid rafts an oar in the lifeboat? Mol Nutr Food Res 54:631–640

    Article  Google Scholar 

  10. Ong DE (1994) Absorption of vitamin A. In: Blomhoff R (ed) Vitamin A in health and disease. Marcel Dekker, New York, pp 37–72

    Google Scholar 

  11. Reboul E, Borel P (2011) Proteins involved in uptake, intracellular transport and basolateral secretion of fat-soluble vitamins and carotenoids by mammalian enterocytes. Prog Lipid Res 50:388–401

    Article  CAS  PubMed  Google Scholar 

  12. Reboul E, Goncalves A, Comera C, Bott R, Nowicki M, Landrier JF, Jourdheuil-Rahmani D, Dufour C, Collet X, Borel P (2011) Vitamin D intestinal absorption is not a simple passive diffusion: evidences for involvement of cholesterol transporters. Mol Nutr Food Res 55:691–702

    Article  CAS  PubMed  Google Scholar 

  13. Shearer MJ, Fu X, Booth SL (2012) Vitamin K nutrition, metabolism, and requirements: current concepts and future research. Adv Nutr 3:182–185

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  14. Takada T, Suzuki H (2010) Molecular mechanisms of membrane transport of vitamin E. Mol Nutr Food Res 54:616–622

    Article  CAS  PubMed  Google Scholar 

  15. Wang DQH (2007) Regulation of intestinal cholesterol absorption. Annu Rev Physiol 69:221–248

    Article  CAS  PubMed  Google Scholar 

  16. Wang LJ, Song BL (2012) Niemann-Pick C1-Like 1 and cholesterol uptake. Biochim Biophys Acta 1821:964–972

    Article  CAS  PubMed  Google Scholar 

  17. Wolf G (1991) The intracellular vitamin A-binding proteins: an overview of their functions. Nutr Rev 49:1–12

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Michael D. Sitrin M.D. .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Sitrin, M.D. (2014). Digestion and Absorption of Other Dietary Lipids. In: Leung, P. (eds) The Gastrointestinal System. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-8771-0_8

Download citation

Publish with us

Policies and ethics