Abstract
The development of cell reprogramming technology will alter many clinical situations, including immunotherapy. One instance is donor lymphocyte infusion (DLI) therapy. DLI is an effective therapy for lymphoma or leukemia patient for the inhibition of relapses after bone marrow transplantation (BMT). However, DLI treatment depends on the availability of T lymphocytes isolated from a donor for the generation of lymphocytes. The application of cell reprogramming technology facilitates the generation of lymphocytes without donor apheresis, offering a sustainable and repeatable DLI therapy. In this chapter, we show an instance of this new age immunotherapy that utilizes cell reprogramming technology.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006;126(4):663–76. doi:10.1016/j.cell.2006.07.024.
Mellman I, Coukos G, Dranoff G. Cancer immunotherapy comes of age. Nature. 2011;480(7378):480–9. doi:10.1038/nature10673.
Drake CG. Combination immunotherapy approaches. Ann Oncol. 2012;23(Suppl 8):viii41-46. doi:10.1093/annonc/mds262.
Chang YJ, Huang XJ. Donor lymphocyte infusions for relapse after allogeneic transplantation: when, if and for whom? Blood Rev. 2013;27(1):55–62. doi:10.1016/j.blre.2012.11.002.
Wada H, Kojo S, Kusama C, Okamoto N, Sato Y, Ishizuka B, Seino K. Successful differentiation to T cells, but unsuccessful B-cell generation, from B-cell-derived induced pluripotent stem cells. Int Immunol. 2011;23(1):65–74. doi:10.1093/intimm/dxq458.
Yamaguchi TP, Dumont DJ, Conlon RA, Breitman ML, Rossant J. flk-1, an flt-related receptor tyrosine kinase is an early marker for endothelial cell precursors. Development. 1993;118(2):489–98.
Kabrun N, Buhring HJ, Choi K, Ullrich A, Risau W, Keller G. Flk-1 expression defines a population of early embryonic hematopoietic precursors. Development. 1997;124(10):2039–48.
Nakano T, Kodama H, Honjo T. Generation of lymphohematopoietic cells from embryonic stem cells in culture. Science. 1994;265(5175):1098–101.
Schmitt TM, Zuniga-Pflucker JC. Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro. Immunity. 2002; 17(6):749–756. doi: S1074761302004740.
Koch U, Fiorini E, Benedito R, Besseyrias V, Schuster-Gossler K, Pierres M, Manley NR, Duarte A, Macdonald HR, Radtke F. Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment. J Exp Med. 2008;205(11):2515–23. doi:10.1084/jem.20080829.
Sobin LH, Kidd JG. Alterations in protein and nucleic acid metabolism of lymphoma 6C3HED-og cells in mice given guinea pig serum. J Exp Med. 1966;123(1):55–74.
Janson PC, Marits P, Thorn M, Ohlsson R, Winqvist O. CpG methylation of the IFNG gene as a mechanism to induce immunosuppression [correction of immunosupression] in tumor-infiltrating lymphocytes. J Immunol. 2008;181(4):2878–2886. doi:10.4049/jimmunol.181.4.2878
Vizcardo R, Masuda K, Yamada D, Ikawa T, Shimizu K, Fujii S, Koseki H, Kawamoto H. Regeneration of human tumor antigen-specific T cells from iPSCs derived from mature CD8(+) T cells. Cell Stem Cell. 2013;12(1):31–6. doi:10.1016/j.stem.2012.12.006.
Nishimura T, Kaneko S, Kawana-Tachikawa A, Tajima Y, Goto H, Zhu D, Nakayama-Hosoya K, Iriguchi S, Uemura Y, Shimizu T, Takayama N, Yamada D, Nishimura K, Ohtaka M, Watanabe N, Takahashi S, Iwamoto A, Koseki H, Nakanishi M, Eto K, Nakauchi H. Generation of rejuvenated antigen-specific T cells by reprogramming to pluripotency and redifferentiation. Cell Stem Cell. 2013;12(1):114–26. doi:10.1016/j.stem.2012.11.002.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2015 The Author(s)
About this chapter
Cite this chapter
Wada, H., Baghdadi, M., Seino, Ki. (2015). Generation of T-Lineage Cells from iPS Cells and Its Application. In: Cheng, T. (eds) Hematopoietic Differentiation of Human Pluripotent Stem Cells. SpringerBriefs in Stem Cells, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-7312-6_6
Download citation
DOI: https://doi.org/10.1007/978-94-017-7312-6_6
Published:
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-017-7311-9
Online ISBN: 978-94-017-7312-6
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)