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Microcapsule Formulation and Formation

  • Chapter
Fundamentals of Cell Immobilisation Biotechnology

Part of the book series: Focus on Biotechnology ((FOBI,volume 8A))

Abstract

Microcapsules are referred to capsules of spherical shape with a diameter of about 100 to 1000 pm. Besides traditional capsules with a well defined shell and core structure, encapsulation in microbeads without a distinct membrane has also been successful in certain applications. For immobilisation of living cells such as bacteria, yeast or mammalian cells, the encapsulation needs to be performed under relative mild conditions, depending on the cell type. The capsules or beads should be semipermeable to allow diffusion of oxygen and nutrients into the cells inside the capsules and waste products out of the capsules. For immunoisolation purposes, the capsule must be impermeable to host cells and soluble components of the immune system.

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Authors and Affiliations

  1. Department of Biotechnology, Norwegian University of Science and Technology, Trondheim, Norway

    Berit L. Strand & Gudmund Skjåk-Bræk

  2. FMC Biopolymer, P.O. Box 494, Brakerøya, N-3002, Drammen, Norway

    Olav Gåserød

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  1. Berit L. Strand
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  2. Gudmund Skjåk-Bræk
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  1. University of Belgrade, Belgrade, Serbia and Montenegro

    Viktor Nedović

  2. Free University of Brussels, Brussels, Belgium

    Ronnie Willaert

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Strand, B.L., Skjåk-Bræk, G., Gåserød, O. (2004). Microcapsule Formulation and Formation. In: Nedović, V., Willaert, R. (eds) Fundamentals of Cell Immobilisation Biotechnology. Focus on Biotechnology, vol 8A. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-1638-3_9

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