Abstract
The tetracyclines are broad spectrum bacteriostatic drugs, three of which are natural fermentation products and have been available since about 1950. There are also several semi-synthetic derivatives. Two of the natural tetracyclines, oxytetracycline (OTC) and chlortetracycline, have been used in aquaculture; OTC in particular has been widely used because in most markets it is not only available but also cheaper than other broad-spectrum antibacterial drugs. Of the semi-synthetic derivatives tetracycline and doxycycline have been used in aquaculture but to only a limited extent; they are more expensive than OTC and whatever their pharmacokinetic merits the long usage of OTC has meant that many bacterial pathogens are resistant to the whole group.
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Björklund, H. and Bylund, G. (1990) Temperature-related absorption and excretion of oxytetracycline in rainbow trout (Salmo gairdneri R.). Aquaculture 84, 363–372.
Elema, M.O., Hoff, K.A. and Kristensen, H.G. (1996) Bioavailability of oxytetracycline from medicated feed administered to Atlantic salmon (Salmo salar L.) in seawater. Aquaculture 143, 7–14.
Grondel, J.L., Nouws, J.F.M., Schutte, A.R. and Driessens, F. (1989) Comparative pharmacokinetics of oxytetracycline in rainbow trout (Salmo gairdneri) and African catfish (Clarias gariepinus). Journal of Veterinary Pharmacology and Therapeutics 12, 157–162.
Jacobsen, M.D. (1989) Withdrawal times of freshwater rainbow trout, Salmo gairdneri Richardson, after treatment with oxolinic acid, oxytetracycline and trimethoprim. Journal of Fish Diseases 12, 29–36.
Lunestad, B.T. and Goks¢yr, J. (1990) Reduction in the antibacterial effect of oxytetracycline in sea water by complex formation with magnesium and calcium. Diseases of Aquatic Organisms 9, 67–72.
Namdari, R., Abedini, S. and Law, F.C.P. (1996) Tissue distribution and elimination of oxytetracycline in seawater chinook and coho salmon following medicated feed treatment. Aquaculture 144, 27–38.
Pursell, L., Dineen, T., Kerry, J., Vaughan, S. and Smith, P. (1996) The biological significance of breakpoint concentrations of oxytetracycline in media for the examination of marine sediment microflora. Aquaculture 145, 21–30.
Rijkers, G.T., Teunissen, A.G., van Oosterom, R. and van Muiswinkel, W.B. (1980) The immune system of cyprinid fish. The immunosuppressive effect of the antibiotic oxytetracycline in carp (Cyprinus carpio L.). Aquaculture 19, 177–189.
Rogstad, A., Ellingsen, O.F. and Syvertsen, C. (1993) Pharmacokinetics and bioavailability of flumequine and oxolinic acid after various routes of administration to Atlantic salmon in seawater. Aquaculture 110, 207–220
Smith, P. (1996) Is sediment deposition the dominant fate of oxytetracycline used in marine salmonid farms: a review of the available evidence. Aquaculture 146, 157–169.
Smith, P. and Samuelsen, O.B. (1996) Estimates of the significance of outwashing of oxytetracycline from sediments under Atlantic salmon sea-cages. Aquaculture 144, 17–26.
Strasdine, G.A. and McBride, J.R. (1979) Serum antibiotic levels in adult sockeye salmon as a function of route of administration. Journal of Fish Biology 15, 135–140.
Vaughan, S. and Smith, P. (1996) Estimation of the influence of a river sediment on the biological activity of oxytetracycline hydrochloride. Aquaculture 141, 67–76
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© 2000 Springer Science+Business Media Dordrecht
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Treves-Brown, K.M. (2000). Tetracyclines. In: Applied Fish Pharmacology. Aquaculture, vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-0761-9_5
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DOI: https://doi.org/10.1007/978-94-017-0761-9_5
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