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Epidemiologic Aspects of the Problem of Congenital Malformations

  • Chapter
Problems of Birth Defects

Abstract

Increasing interest in congenital defects raises the question of their incidence. No extensive examination of the world literature was found so an attempt was made to provide a broad conspectus of the available data. This shows great variety of procurement and recording, and underreporting appears to be probable. The need for agreement on standardized diagnostic criteria and recording methods is emphasized.

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References

  1. Abou-Daoud, K. T.: Congenital malformations observed in 12,146 births at the American Hospital of Beirut. J. méd. liban. 19:113–121, 1966.

    PubMed  CAS  Google Scholar 

  2. Aicardi, G.; Rugati, S. and Acinelli, G.: [Congenital malformations seen in the Obstetric and Gynecological Clinic of Sassari, 1936 to 1965. Note 1. Statistical considerations.] Minerva pediat. 18:73–79, 1966.

    PubMed  CAS  Google Scholar 

  3. Alison, F.: [Enquiry on embryopathies and diseases of pregnancy.] Rev. Hyg. Méd. soc. 7:97–105, 1959.

    PubMed  CAS  Google Scholar 

  4. Alpen, H. U. H. von: Congenital abnormalities. A survey of abnormalities encountered at the Q.E.M.H. from opening in 1954 to December, 1962. S. Austral. Clin. 1:167–170, 1965.

    Google Scholar 

  5. Altemus, L. A. and Ferguson, A. D.: Comparative incidence of birth defects in negro and white children. Pediatrics 36: 56–61, 1965.

    PubMed  CAS  Google Scholar 

  6. Araujo, J. de: [Congenital malformations.] Pediat. prát. (S. Paulo) 34:131–138, 1963.

    Google Scholar 

  7. Aresin, N. and Somer, K. H.: [Malformations and environmental factors.] Zbl. Gynäk. 72:1329–1336, 1950.

    CAS  Google Scholar 

  8. Avanzini, P. and Girando, G.: [Incidence of congenital malformations consequent on pandemic influenza.] Minerva pediat. 12:120, 1960.

    PubMed  CAS  Google Scholar 

  9. Avezzu, G. and Vinci, G. W.: [Fetal malformations and conditions possibly due to various teratogenic causes.] Ann. Ostet. Ginec. 88:49–72, 1960.

    Google Scholar 

  10. Azer, V.: [Contribution to the study of fetal and congenital malformations.] Thesis, Lyons 1944, quoted by Lamy et al.

    Google Scholar 

  11. Baird. Sir Dugald: Variations in fertility associated with changes in health status. J. chron. Dis. 18:1109-1124, 1965.

    Google Scholar 

  12. Baron, F.; Michiels, Y. and Rochas. J. E.: [Influenza and fetal malformations, statistical considerations.] Gynéc. et Obstét. 59:271–276, 1960.

    CAS  Google Scholar 

  13. Baucks, K. D.: [Child malformations.] Geburtsh. U Frauenheilk. 22:144–155, 1962.

    CAS  Google Scholar 

  14. Beolchini, P. E.: [Statistical and genetic research on congenital malformations. 11. The frequency of malformations seen at the Milan Maternity Hospital in 85,976 babies between 1942 and 1946.] Acta Genet. med. (Roma) 13:203–215, 1964.

    Google Scholar 

  15. Biering-Sørcnsen, K.: Congenital malformations and antihistamine drugs. Bull. Soc. roy. belge Gynéc. Obstét. 33:87–93, 1963.

    Google Scholar 

  16. Bierman, S. M.; Siegel, E.: French, F. E. and Simonian, K.: Analysis of the outcome of all pregnancies in a community. Amer. J. Obstet. Gynec. 91:37–45, 1965.

    PubMed  CAS  Google Scholar 

  17. Bjøro, K. and Iversen, S.: [Survey of congenital malformations from an obstetric point of view.] T. norske Laege-foren. 79:1308–1312, 1959.

    Google Scholar 

  18. Boldt, H. D.: Congenital malformations in Ethiopia. Ethiopian Med. J. 4:43–45, 1965.

    Google Scholar 

  19. Bologna, V.: [Congenital malformations of the fetus. Report of 299 cases.] Clin. ostet. ginec. 56:268–291, 1955.

    Google Scholar 

  20. Böök, J.A.: The incidence of congenital diseases and detects in a South Swedish population. Acta genet. (Basel) 2:289–311, 1951.

    Google Scholar 

  21. Böök, J.A. and Fraccaro, M.: Research on congenital malformations. Neo-Natal Studies. 5:39–54, 1956.

    PubMed  Google Scholar 

  22. Bovev Velichkova; Markova and Iordanav: [Incidence, types and etiology of congenital malformations in children.] Suvr. Med. 14:8-17, 1963.

    Google Scholar 

  23. Büchi, E. C.: Bull. Schweiz. Ges. Anthrop. Ethnol. 26:11, 1950, quoted by Böök and Fraccaro.

    Google Scholar 

  24. Burge, E. S.: Relationship of threatened abortion to fetal abnormalities. Amer. J. Obstet. Gynec. 61:615–621, 1951.

    PubMed  CAS  Google Scholar 

  25. Buurman, G.; Langendörfer, G.; Noack, J. and Witt, H. J. [Occurrence of congenital abnormalities in the last 55 years.] Zbl. Gynä k. 80:1432–1442, 1958.

    Google Scholar 

  26. Calvani, M.: [Statistical data on 359 cases of congenital malformations in newborn babes.] lnfanzia 11:520–524, 1961.

    Google Scholar 

  27. Campli, C. and Pedone, G.: [Review of the malformations in Foggia Maternity Hospital.] Minerva ginec. 11:99–103, 1962.

    Google Scholar 

  28. Carollo, F.; Fiorino, S. and Candela, G.: [Congenital malformations seen in the Obstetric and Gynecological Clinic of Palermo University. Clinical and statistical study.] Sicilia sanit. 11-12:1–48, 1964.

    Google Scholar 

  29. Carter, C. O.: Maternal states in relation to congenital malformations. J. Obstet. Gynaec. Brit. Emp. 57:897–911, 1950.

    Article  PubMed  CAS  Google Scholar 

  30. Charles, E.: Statistical utilization of maternity and child welfare records. Brit. J. prev. soc. Med. 5:41–61, 1951.

    CAS  Google Scholar 

  31. Cocozza, G. and Tiso, E.: [Clinico-statistical contribution on embryopathic malformations.] Pediatria (Napoli) 63: 822–844, 1955.

    CAS  Google Scholar 

  32. Coffey, V. P. and Quinn, P.: Domiciliary deliveries in Dublin. J. Irish med. Ass. 59:44–54, 1966.

    CAS  Google Scholar 

  33. Colucci, G. and Tosolini, G. C.: [Fetal malformations in the Obstetrical and Gynecological Department of the Civil Hospital of Udine.] Attual. Ostet. Ginec. 9:1–22, 1963.

    Google Scholar 

  34. Conway, H. and Wagner, K. J.: Congepital abnormalities reported on birth certificates in New York City 1952–1962. N. Y. St. J. Med. 65:1087–1090, 1965.

    CAS  Google Scholar 

  35. Corner, B. D.: Congenital anomalies, clinical considerations. Med. J. S.-W. 77:46–52, 1962.

    CAS  Google Scholar 

  36. Craig, W. S.: Care of the newly born infant. 3rd edn., Livingston, Edinburgh, 1965.

    Google Scholar 

  37. Cretius, K. and Fuchs, R.: [Report on the unusual increase in micromelia and amelia in 1961 in the Obstetric Clinic, Würzburg University.] Med. Klin. 57:923–927, 1962.

    PubMed  CAS  Google Scholar 

  38. Da Rugna, D.: [Frequency of severe congenital malformations in the Women’s Hospital, Basel.] Medikamentöse Pathogenese fetale Missbildungen. Symposium in Liestal, 29/30 March, 1963. 116–123. Karger, Basel, 1964.

    Google Scholar 

  39. Davis, M. E. and Potter, E. L.: Congenital malformations and obstetrics. Pediatrics 19:719–724, 195

    PubMed  CAS  Google Scholar 

  40. Dean, N. M. B.: in press.

    Google Scholar 

  41. Dedukh, L. G. and Lankovits, A. V.: [Some data on developmental defects in the newborn.] Vop. Okhrany Materin. Dets. 10:65–68, 1965.

    CAS  Google Scholar 

  42. Dellepiane, G. and Colla, G.: [On the etiopathogenesis of congenital dysmelias.] Minerva ginec. 14:1029–1040, 1962.

    PubMed  CAS  Google Scholar 

  43. De Porte, J. V. and Parkhurst, E.: Congenital malformations and birth injuries among children born in N.Y. State 1940–1942. N. Y. St. J. Med. 45:1097–1100, 1945.

    Google Scholar 

  44. Derom, R.: [New statistics on the frequency of certain malformations in Belgium.] Bull. Soc. roy. belge Gynéc. Obstét. 33:143–148, 1963.

    Google Scholar 

  45. Eichmann, E. and Gesenius. H.: [The increase in congenital malformations in Berlin and environs after the war.] Arch. Gymik. 181:168–184, 1952.

    CAS  Google Scholar 

  46. Elsie Inglis Hospital. Edinburgh. Annual Report 1948–1949.

    Google Scholar 

  47. Elsner-Mackay, P.: [Exogenous malformations.] Wien. klin. Wschr. 76:181–189, 1964.

    PubMed  CAS  Google Scholar 

  48. Emerson, R. G.: Obstetric practice in the tropics. Trans. roy. Soc. trop. Med. Hyg. 58:589–592, 1965.

    CAS  Google Scholar 

  49. Erhardt, C. L. and Nelson, F. G.: Reported congenital malformations in New York City 1958–1959. Amer. J. publ. Hlth 54:1489–1506, 1964.

    Article  CAS  Google Scholar 

  50. Evans, T. N. and Brown, G. C: Congenital anomalies and virus infections. Amer. J. Obstet. Gynec. 87:749–761, 1963.

    PubMed  CAS  Google Scholar 

  51. Farrer, J. F. and Mackie, I. J.: Survey of possible causes of congenital malformations. Med. J. Aust. ii:702–704, 196

    Google Scholar 

  52. Ferrario, E. and Fortuna, A.: [Clinical and statistical data on fetal malformations seen in the Novaro Commune Maternity Hospital in the last twenty years.] Minerva ginec. 2:248–257, 1950.

    PubMed  CAS  Google Scholar 

  53. Figueroa, M. J. and Manterola. A. A.: [Some considerations on malformations seen in 63,340 viable children in 10 years in the Barros Luco Hospital.] Pediatria (Santiago) 3:331–334, 1960.

    Google Scholar 

  54. Fink, A.: [Malformations and their correlation with the mother’s age.] Z. Geburtsh. Gynä k. 147:214–226, 1956.

    CAS  Google Scholar 

  55. Fiuza Perez, L.: [Genetic and hereditary factors in the development of congenital malformations. Study of 690 cases.] Acta pediá t. esp. 16:367–382, 1958.

    CAS  Google Scholar 

  56. Frazier, T. M.: A note on race specific congenital malformation rates. Amer. J. Obstet. Gynec. 80:184–185, 1960.

    PubMed  CAS  Google Scholar 

  57. Gentry, J. T.; Parkhurst, E. and Bulin, E. V., Jr.: Epidemiological study of congenital malformations in New York State. Amer. J. publ. Hlth 49:497–513, 1959.

    Article  CAS  Google Scholar 

  58. Ghosh, S. and Bali, L.: Congenital malformations in the newborn. Indian J. Child Hlth 448-452, July, 1963.

    Google Scholar 

  59. Glietenberg, H.: Congenital malformations from the obstetricians point of view. S. Afr. med. J. 161-164, February 18, 1967.

    Google Scholar 

  60. Gonzales-Coviella, L.: [Incidence of congenital malformations in 20,221 newborn babes.] Rev. esp. Pediat. 21:767–776, 1965.

    Google Scholar 

  61. Götz, G.: [The problem of malformations. Report on 645 cases.] Med. Klin. 55:577–583, 1960.

    Google Scholar 

  62. Greco, E.; Landi, E. and Rubino, S.: [The high incidence of congenital malformations in Gorgano.] Clin. pediat. (Bologna) 44:96–126, 1962.

    CAS  Google Scholar 

  63. Green, C. R.: The incidence of human maldevelopment. Amer. J. Dis. Child. 105:301–312, 1963.

    PubMed  CAS  Google Scholar 

  64. Greenberg, M.; Yankauer, A.; Krugman, S.; Osborn, J. J.; Ward, R. S. and Dancis, J.: The effect of smallpox vaccination during pregnancy on the incidence of congenital malformation. Pediatrics 3:456–467, 194

    PubMed  CAS  Google Scholar 

  65. Greenhill, J. P.: Increased incidence of fetal abnormalities in cases of placenta previa. Amer. J. Obstet. Gynec. 37:624–633, 1939.

    Google Scholar 

  66. Griffin, G. V. and Sorrie, G. S.: Congenital abnormalities in Reading 1958–1963. Med. Offr 112:197–198, 1964.

    Google Scholar 

  67. Halevi, H. S.: Congenital malformations in Israel. Brit. J. prev. soc Med. 21:66–77, 1967.

    CAS  Google Scholar 

  68. Hartman, E. E. and Kennedy, R. L. J.: Illness in the first trimester, its lack of significance in relation to congenital anomaly of prematurity and still birth. J. Pediat. 38:306–309, 1951.

    Article  PubMed  CAS  Google Scholar 

  69. Hautau, E. R.: Congenital malformations in infants born to Michigan residents in 1958. J. Mich. med. Soc: 59:1833–1836, 1960.

    Google Scholar 

  70. Hedberg, E.; Holmdahl, L. K.; Pehrson, S. and Zackrisson. U.: On the relationship between maternal conditions during pregnancy and congenital malformations. Preliminary report. Acta pacdiat. 52:353–360, 1963.

    Article  Google Scholar 

  71. Hegnauer, H.: [Frequency of malformations and age of mother.] Geburtsh. u. Frauenheilk. 11:77–92, 1951.

    Google Scholar 

  72. Hendricks, C. H.: Congenital malformations. Analysis of 1953 Ohio records. Obstet. and Gynec: 6:592–598, 1955.

    Article  CAS  Google Scholar 

  73. Hermann, F.: Inaugural Dissertation. Tübingen, 1939, quoted by Sievers.

    Google Scholar 

  74. Heyne, D.: [Initial statistical elements relative to congenital malformations in Belgium.] Arch. belges Méd. soc 21:186–198, 1963.

    CAS  Google Scholar 

  75. Hirvensalo, M. and Hjelt, L.: [Incidence of congenital malformations in a Finnish Maternity Hospital.] Duodecim (Helsinki) 79:798–803, 1963.

    CAS  Google Scholar 

  76. Hohlbein, R.: [Malformation frequency in Dresden.] Zbl. Gynä k. 81:719–731, 1959.

    CAS  Google Scholar 

  77. Horn, B., Csordas, T.; Dömötöri, J. and Kiszel, J.: [Developmental anomalies.] Zbl. Gynäk. 87:1180–1189, 1965.

    CAS  Google Scholar 

  78. Horner, R. and Lanzkowsky, P.: Incidence of congenital abnormalities in Cape Town. S. Afr. med. J. 40:171, 196

    PubMed  CAS  Google Scholar 

  79. Houstek, J.; Kucera, J. and Kotzmanova, J.: [Incidence of congenital malformations in the Stredocesky Kraj.] Cs. Pediat. 17:458–468, 1962.

    CAS  Google Scholar 

  80. Ingals, T. H. and Kleinberg, M. A.: Congenital malformations. Clinical and community considerations. Amer. J. med. Sci. 249:316–344, 1965.

    Article  Google Scholar 

  81. Ivy, R. H.: Congenital anomalies as recorded on birth certificates in the Division of Vital Statistics of the Pennsylvania Department of Health for the period 1951–1955 inclusive. Plast, reconstr. Surg. 20:400–411, 1957.

    Article  CAS  Google Scholar 

  82. Ivy, R. H.: The influence of race on the incidence of certain congenital anomalies. Plast. reconstr. Surg. 30:581–585, 1962.

    Article  CAS  Google Scholar 

  83. Ivy, R. H.: Congenital anomalies as recorded on birth certificates in the Division of Vital Statistics of the Pennsylvania Department of Health for 1956–1960. Plast. reconstr. Surg. 32:361–367, 1963.

    Article  PubMed  CAS  Google Scholar 

  84. Javert, C. T. and Stander, H. J.: Plasma vitamin C and prothrombin concentrations in pregnancy and in threatened and spontaneous abortions. Surg. Gynec. Obstet. 76:115–122, 1943.

    CAS  Google Scholar 

  85. Jaworska, M.: [Statistical analysis of congenital defects.] Pol. Tyg. lek. 17:209–212, 1962.

    PubMed  CAS  Google Scholar 

  86. John, J.: Inaugural Dissertation. Leipzig, 1942, quoted by Sievers.

    Google Scholar 

  87. Jongco, A. P.; Carlos, F. C. and Fernandez, E. V.: Congenital anomalies in Filipinos. J. Philipp. med. Ass. 41:57–60, 1965.

    PubMed  CAS  Google Scholar 

  88. Kaminura, K.: [Incidence of gross malformations at birth surveyed by the mail questionnaire method.] Jap. J. Pub. Hlth. 12:135–140, 1965.

    Google Scholar 

  89. Karim, M. et al: Congenital deformities in the U. A. R. and Iraq. J. Iraqui med. Prof. 13:57–61, 1965.

    Google Scholar 

  90. Khan, A. A.: Congenital malformations in African neonates in Nairobi. J. trop. Med. Hyg. 68:272–274, 1965.

    PubMed  CAS  Google Scholar 

  91. Kleinman, H.; Prince, J. T.; Mathey, W. E.; Rosenfeld, A. B.; Bearman, J. E. and Syverton, J. T.: Echo 9 virus infection and congenital abnormalities. A negative report. Pediatrics 29:261–269, 196

    PubMed  CAS  Google Scholar 

  92. Klebanov, D. and Hegenauer, H.: [The question of secondary germinative ovarian insufficiency.] Zbl. Gynäk. 73:50–53, 1951.

    Google Scholar 

  93. Klemetti, A.: Relationship of selected environmental factors to pregnancy outcome and congenital malformations. Academic Dissertation, pp. 70. Helsinki, 1966, (and as Supplement 26 to Ann. Paediat. Feenn 26, 1966).

    Google Scholar 

  94. Klosteikötter, W.: Inaugural Dissertation. Cologne, 1943, quoted by Sievers.

    Google Scholar 

  95. Knörr, K.: [The incidence of congenital anomalies considered in relation to their observation and recording.] Geburtsh. u. Frauenheilk. 22:1291–1293, 1962.

    Google Scholar 

  96. Kobielowa, Z.; Kucharska, A. and Ostrowski, A.: [Statistical analysis of congenital defects.] Pol. Tyg. lek. 17:213–216, 1962.

    PubMed  CAS  Google Scholar 

  97. Kohl, S. K.: Community obstetrical study. Hartford County. Connecticut 1960, quoted by Baird.

    Google Scholar 

  98. Kolah, P. J.; Master, P. A. and Sanghvi, L. D.: Congenital malformations and perinatal mortality in Bombay. Amer. J. Obstet. Gynec. 97:400–406, 1967.

    PubMed  CAS  Google Scholar 

  99. Kolbas, V.: [Congenital defects among infants in a region of Croatia.] Lijecn. Vjesn. 86:675–682, 1964.

    CAS  Google Scholar 

  100. Kovacs, I. and Makay, L.: [Problems of the etiology of abnormalities.] Zbl. Gynäk. 82:1335–1341, 1960.

    CAS  Google Scholar 

  101. Kucera, J.: Personal communication, 1967.

    Google Scholar 

  102. Kühne, D.: [Anamnestic investigation of mothers of malformed babes at Rostock University Clinic for Women, 1960–1962.] Zbl. Gynäk. 85:1475–1480, 1963.

    Google Scholar 

  103. Kühnelt, H. J. and Rotter-Pool, P.: [Malformations in the Women’s Clinic of Berlin University in the light of embryopathy.] Zbl. Gynäk. 77:893–400, 1955.

    Google Scholar 

  104. Lamy, M. and Frezal, J.: The frequency of congenital malformations. First International Conference on Congenital Malformations. 1960. 34–44. Lippincott, Philadelphia.

    Google Scholar 

  105. Landazuri Fuentes, H.: [Congenital anomalies, study of 40.000 births in Obrero Hospital, Lima.] Acad. peru. drug. 17:119–125, 1964.

    CAS  Google Scholar 

  106. Landsman, J. B.: Grist, N. R. and Ross, C. A. C: Echo 9 virus and congenital malformations. Brit. J. prev. soc. Med. 18:152–156, 1964.

    CAS  Google Scholar 

  107. Landtman, B.: On the relationship between maternal conditions during pregnancy and congenital malformations. Arch. Dis. Childh. 23:237–240, 1948.

    Article  PubMed  CAS  Google Scholar 

  108. Leck, I.: Examination of the incidence of malformations for evidence of drug teratogenesis. Brit. J. prev. soc. Med. 18:196–201, 1964.

    CAS  Google Scholar 

  109. Leck, I. and Millar, E. L. M.: Short term changes in the incidence of malformations. Brit. J. prev. soc. Med. 17:1–12, 1963.

    CAS  Google Scholar 

  110. Leone, A.: [Malnutrition of the mother as a cause of malformation of the child.] Ann. ital. Pediat. 15:143–160, 1962.

    Google Scholar 

  111. Leonski, E. F.: A consideration of the incidence of common major congenital malformations in a Winnipeg Nursery. Manitoba med. Rev. 42:602–604, 1962.

    Google Scholar 

  112. Le Vann, L. J.: Congenital abnormalities in children born in Alberta during 1961: a survey and a hypothesis. Canad. med. Ass. J. 89:120–126, 1963.

    PubMed  Google Scholar 

  113. Le Vann, L. J.: Congenital abnormalities in children born in Alberta during 1962. A further communication. Alberta med. Bull. 1-10, August, 1965.

    Google Scholar 

  114. Lewin, H. and Fischer, G.: [Report on congenital malformations.] Zbl. Gynäk. 80:413–429, 1958.

    CAS  Google Scholar 

  115. Lindemann, G.: [Incidence of malformation in Halle.] Zbl. Gynäk. 74:876, 1962.

    Google Scholar 

  116. Livadiotti, M.; Formato, R. and La Femina, R.: [Clinico-statistical reports on congenital malformations in St. Camillo de Lellis Maternity Hospital, Rome, 1949–1962.] lnfanzia 14:5–25, 1964.

    Google Scholar 

  117. Lork, E. C: [Incidence of malformations in Rostock] Zbl. Gynäk. 74:877, 1952.

    Google Scholar 

  118. Lucy, R. E.: Study of congenital malformations. J.-Lancet 69:80–81, 1949.

    PubMed  CAS  Google Scholar 

  119. McDonald, A. D.: Maternal health and congenital defect. New Engl. J. Med. 258:767–775, 1958.

    Article  PubMed  CAS  Google Scholar 

  120. Mcintosh, R.; Merritt, K. I.; Richards, M. R.; Samuels, M. H. and Bellows, M. T.: Incidence of congenital malformations, a study of 5,964 pregnancies. Pediatrics 14:505–522, 195

    PubMed  CAS  Google Scholar 

  121. McKeown, T. and Record, R. G.: Malformations in a population observed for five years after birth. Ciba Symposium on Congenital Malformations, London. 2–16, 1960.

    Google Scholar 

  122. MacMahon, B.; Pugh, T. F. and Ipsen, J.: Epidemiological methods. London, 1960.

    Google Scholar 

  123. Maggiore, L.: [Statistics of human congenital malformations in Italy 1956–1958.] Acta Genet. med. (Roma) 12: 276–290, 1960.

    Google Scholar 

  124. Malpas, P.: The incidence of human malformations and the significance of change in the maternal environment in their causation. J. Obstet. Gynaec. Brit. Emp. 44:434–454, 1937.

    Article  Google Scholar 

  125. Manzke, H. and Falck, H. R.: [Malformations in the birth record of Kiel University Obstetric Clinic 1948–1961.] Geburtsh. u. Frauenheilk. 23:1088–1098, 1963.

    CAS  Google Scholar 

  126. Marden, P. M.; Smith, D. W. and McDonald, M. L: Congenital anomalies in the newborn, including minor variaions. J. Pediat. 64:357–371, 1964.

    Article  PubMed  CAS  Google Scholar 

  127. Maurer, E.: Inaugural Dissertation, Tn, 1935, quoted by Sievers.

    Google Scholar 

  128. Mestwerdt, G.: [Frequency of malformations in Hamburg Barmbeck.] Geburtsh. u. Frauenheilk. 23:196–197, 1963.

    Google Scholar 

  129. Mey, R.: [Hyperemesis gravidarum as a possible exogenous cause for congenital malformations.] Zbl. Gynäk. 80:1785–1791, 1955.

    Google Scholar 

  130. Miller, H. C: Scope and incidence of congenital malformations. Pediatrics 5:320–324, 195

    PubMed  CAS  Google Scholar 

  131. Mischel: [Frequency of malformations in Altona Obstetric Clinic] Geburtsh. u. Frauenheilk. 23:196, 1963.

    Google Scholar 

  132. Mitani, S.: Malformations of the newborn and fetus. International Congress Gynecology and Obstetrics. S. A. Sandoz, Basel, 1954.

    Google Scholar 

  133. Miyamoto, K.: [Congenital malformations: 4 year study.] J. Jap. obstet. gynaec. Soc. 16:531–535, 1964.

    Google Scholar 

  134. Morandi, E. and Marchesoni, M.: Incidence of congenital malformations following meclizine therapy in the first three months of pregnancy. Bull. Soc. roy. belge Gxnéc. Obstét. 33:139–142, 1963.

    Google Scholar 

  135. Morra, C. and Cremona, G. F.: [Problems connected with fetal malformations. Incidence and clinical aspects of fetal malformations observed at the S. Anna Maternity Hospital in Turin.] Minerva ginec. 15:779–783, 1963.

    PubMed  CAS  Google Scholar 

  136. Mosing, K.: [An unusual case of ectromelia and developmental defects of newborn infants.] Pol. Tyg. lek. 19:227–230, 1962.

    Google Scholar 

  137. Moss, B. J. L.: Congenital abnormalities in Leicester, 1953–1962. Med. Offr 79-82, 31 July, 1964.

    Google Scholar 

  138. Murphy, D. P.: Congenital defects. Incidence among siblings of first congenially malformed children in 275 families. J. Amer. med. Ass. 106:457–458, 1936.

    Article  Google Scholar 

  139. Nagy, T.; Bazso, J. and Lampe, L.: [Frequency of malformations in the clinical records of our hospital.] Zbl. Gynäk. 83:866–880, 1961.

    CAS  Google Scholar 

  140. Nair, N. S. and Mathai, N. M.: Congenital malformations in the newborn at Calicut. A preliminary report. Antiseptic 61:823–829, 196

    Google Scholar 

  141. Naujoks, H.: [Occurrence and treatment of malformations and birth injuries in the newborn.] Arch. Gynäk. 166:445–455, 1938.

    Article  Google Scholar 

  142. Neel, J. W.: A study of major congenital defects in Japanese infants. Amer. J. hum. Genet. 10:398–445, 1958.

    PubMed  CAS  Google Scholar 

  143. Nelson, A. M.: in press.

    Google Scholar 

  144. Newton, L. and McLean, T.: Microcephaly in three successive pregnancies. Conn. med. J. 11:617–619, 1947.

    CAS  Google Scholar 

  145. Niemetz, K.: Inaugural Dissertation. Rostock, 1938, quoted by Sievers.

    Google Scholar 

  146. Nobili, F.: [External causes of congenital malformations.] Minerva ginec. 15:1137–1151, 1963.

    PubMed  CAS  Google Scholar 

  147. Nowak, J.: [Frequency of congenital malformations after the war years, 1945–1949.] Zbl. Gynäk. 72:1313–1328, 1950.

    CAS  Google Scholar 

  148. Ockel, E. and Klemm, P.G.: [Epidemiological study of the malformation problem.] Santé publ. (Buc.) 7:413–431, 1965.

    Google Scholar 

  149. Oster, H.: [Incidence of malformations and anlage disorders in newborn infants.] Kinderärztl. Prax. 27:28–32, 1959.

    PubMed  CAS  Google Scholar 

  150. Osterud, H. T. and Menashe, V. D.: The congenitally malformed. I. The problem. Northw. Med. (Seattle) 64:337–341, 1965.

    CAS  Google Scholar 

  151. Pedersen, L. M.; Tygstrup, I. and Pedersen, J.: Congenital malformations and maternal diabetes. Lancet i:1124–1126, 196

    Article  Google Scholar 

  152. Pereyma, K.: Inaugural Dissertation. Erlangen, 1950, quoted by Sievers.

    Google Scholar 

  153. Pfau, P. and Tor, F.: [Statistical observations on the increase of congenital malformations in the Obstetric Clinic, Heidelberg University, 1927–1957.] Z. Geburtsh. Gynäk. 158:229–236, 1962.

    CAS  Google Scholar 

  154. Piccioni, V.: [Deficiencies of maternal nutrition and congenital fetal malformations.] Clin. ostet. ginec. 57:24–37, 1955.

    PubMed  CAS  Google Scholar 

  155. Pitt, D. B.: Study of congenital malformations. Aust. N. Z. J. Obstet. Gynaec. 2:23–27, 1962.

    Article  Google Scholar 

  156. Pleydell, M. J.: Ancephaly and other congenital abnormalities. An epidemiological study in Northamptonshire. Brit. med. J. 1:309–314, 1960.

    Article  PubMed  CAS  Google Scholar 

  157. Pomerants, S. A. and Chukanina, L. K.: [Congenital defects in development.] Med. Zh. Uzbek. 9:53–56, 1966.

    Google Scholar 

  158. Poole, T. R.: Congenital malformations in West Virginia. W. Va. med. J. 56:16–21, 1960.

    CAS  Google Scholar 

  159. Popa, S. and Iliescu, A.: [Some factors producing congenital malformations.] Rev. med.-chir. (Jassy) 70:607–614, 1966.

    Google Scholar 

  160. Präger, E.: Inaugural Dissertation. Berlin, 1940, quoted by Sievers.

    Google Scholar 

  161. Prediger, F.: [Contribution to the question of the increase of congenital malformations.] Zbl. Gynäk. 83ii: 1053–1060, 1961.

    Google Scholar 

  162. Radanov, D.; Stojanov, S. and Sachariev, B.: [Incidence and cause of malformations in the newborn.] Dtsch. Gesundh.-Wes. 19:392–395, 1964.

    Google Scholar 

  163. Ravina, J.; Daunay, J. J. and Benamour, P.: [One hundred and fifty-two malformations: their relative frequency at certain times of the year.] Bull. Féd. Soc. Gynéc. Obstét. franç. 6:91–121, 195

    Google Scholar 

  164. Rechenberger, H. G.: Inaugural Dissertation. Leipzig, 1945, quoted by Sievers.

    Google Scholar 

  165. Reiffenstuhl, G.: [Malformations of the newborn in Graz University Maternity Clinic 1946–1961.] Zbl. Gynäk. 86: 889–895, 1964.

    CAS  Google Scholar 

  166. Roszkowski, I. and Kietlinska, Z.: Etiology of congenital malformations in the newborn. A clinical study. Obstet. and Gynec. 23:893–897, 1964.

    CAS  Google Scholar 

  167. Saxen, L. and Härö, S.: [Congenital malformations of newborn infants in Finland, 1957–1962.] Duodecim (Helsinki) 80:257–263, 1964.

    CAS  Google Scholar 

  168. Schenk, H.: [Malformations in the years 1938–1941 in the Womens Clinic of Berlin University.] Zbl. Gynäk. 46:2078, 1942.

    Google Scholar 

  169. Schlosser, G. A.: [On the problem of the frequency of malformations.] Med. Klin. 57:1616–1621, 1962.

    PubMed  CAS  Google Scholar 

  170. Schnellerova, M.; Nováková, M. and Dufková, V.: [Incidence of congenital defects in the Neonatal Department of the University Hospital in Brno in 1957–1961.] Cs. Pediat. 19:193–197, 1964.

    CAS  Google Scholar 

  171. Schubert, E. V.: [The inadequacy of malformation statistics from maternity hospitals.] Geburtsh. u. Frauenheilk. 19:475–490, 1959.

    Google Scholar 

  172. Segall, A.; MacMahon, B. and Hannigani, I.: Congenital malformations and background radiation in Northern New England. J. chron. Dis. 17:915–932, 1964.

    Article  PubMed  CAS  Google Scholar 

  173. Sesgin, M. Z. and Stark, R. B.: The incidence of congenital defects. Plast. reconstr. Surg. 27:261–267, 1961.

    Article  CAS  Google Scholar 

  174. Shapiro, R. N.; Eddy, W.; Fitzgibbon, J. and O’Brien, G.: Incidence of congenital anomalies discovered in the neonatal period. Amer. J. Surg. 96:396–400, 1958.

    Article  PubMed  CAS  Google Scholar 

  175. Shapiro, S.; Ross, L. J. and Levine, H. S.: Relationship of selected prenatal factors to pregnancy outcome and congenital anomalies. Amer. J. publ. Hlth 55:268–282, 1965.

    Article  CAS  Google Scholar 

  176. Sheldon, W. H.: Varieties of delinquent youth. Harper, N.Y. 1949.

    Google Scholar 

  177. Sievers, G.: [Problem of the frequency of congenital malformations.] Med. Klin. 60:1761–1768, 1965.

    PubMed  CAS  Google Scholar 

  178. Silberg, S. L.; Marienfield, C. J.; Wright, H. and Arnold, R. C: Surveillance of congenital anomalies in Missouri 1953–1964. Arch. environm. Hlth 13:641–644, 1966.

    Article  CAS  Google Scholar 

  179. Simpkiss, M. and Lowe, A.: Congenital abnormalities in the African newborn. Arch. Dis. Childh. 36:404–406, 1961.

    Article  PubMed  CAS  Google Scholar 

  180. Simpson Maternity Hospital, Edinburgh, Annual Reports, 1938–1948; 1955–1963.

    Google Scholar 

  181. Slater, B. C.; Watson, G. I. and McDonald, J. C: Seasonal variations in congenital abnormalities. Brit. J. prev. soc. Med. 18:1–7, 1964.

    CAS  Google Scholar 

  182. Smithells, R. W.: The Liverpool congenital abnormalities registry. Devel. Med. Child Neurol. 4:320–324, 1962.

    Article  CAS  Google Scholar 

  183. Soergel, W.: [The increase of deformities of limb and ear since 1960 with reference to exogenous factors.] Geburtsh. u. Frauenheilk. 22:1473–1481, 1962.

    CAS  Google Scholar 

  184. Spoto, P.: [Clinical and statistical data on fetal malformations.] Lattante 18:338, 1947.

    PubMed  CAS  Google Scholar 

  185. Stähler, F.: [Geographical differences in frequency of malformations in children.] Geburtsh. u. Frauenheilk. 22:1288–1291, 1962.

    Google Scholar 

  186. Stark, A. M.: A report of two cases of iniencephalus. J. Obstet. Gynaec. Brit. Emp. 58:462–464, 1951.

    Article  PubMed  CAS  Google Scholar 

  187. Stevenson, A. C. and Warcock, H. A.: Observations on the result of pregnancies in women resident in Belfast. I. Data relating to all pregnancies ending in 1957. Ann. hum. Genet. 23:382–394, 1959.

    Article  PubMed  CAS  Google Scholar 

  188. Stevenson, A. C; Johnston, H. A.; Stewart, M. I. P. and Golding, D. R.: Congenital malformations. A report of a series of consecutive births in 24 centres. Bull. Wld Hlth Org. 34:Suppl. 1–127, 196

    Google Scholar 

  189. Stevenson, S. S.; Worcester, J. and Rice, R. G.: Congenital malformed infants associated gestational characteristics. I. General considerations; II. Parental factors. Pediatrics 6: 37–50; 208-222, 1950.

    PubMed  CAS  Google Scholar 

  190. Strohofer, M.: Inaugural Dissertation. München, 1933, quoted by Sievers.

    Google Scholar 

  191. Tabuchi, A. et al. Study on epidemiological factors affecting the frequency of occurrences of congenital anomalies. Hiroshima J. med. Sci. 11:143–158, 1962.

    Google Scholar 

  192. Tholen, A.: [Congenital malformations with special reference to rubella during pregnancy.] Geneesk. Gids 24:338–340, 1946.

    Google Scholar 

  193. Thorn, J. C: [4524 babies: statistical review of all live born babies in the Karl Bremer Hospital, 1961–62. S. Afr. med. J. 38:548, 1964.

    Google Scholar 

  194. Torricelli, C., et al: Minerva nipiol. 12:2, 1962, quoted by Avezzu and Vinci.

    Google Scholar 

  195. Turpin, R.: [Etiology of malformations.] Presse méd. 3: 857–860, 1955.

    Google Scholar 

  196. Vasquez, L-A.; Pascual-Problete, E. and Jongco, A: Congenital malformations in the newborn. J. Philipp. med. Ass. 41:294–304, 1965.

    Google Scholar 

  197. Vignali, M.: [Statistical studies of the pathogenetic factors of fetal abnormalities. Clinical and statistical research on malformations 1943–1960.] Folia hered. path. (Milano) 11:257–275, 1962.

    CAS  Google Scholar 

  198. Villumsen, A. L. and Zachau-Christiansen, B.: Incidence of malformations in the newborn in a prospective child health study. Bull. Soc. roy. belge Gynec. Obstét. 33:95–105, 1963.

    Google Scholar 

  199. Wacker, M. N.: Congenital abnormalities. Amer. J. Obstet. Gynec. 86:310–320, 1963.

    PubMed  CAS  Google Scholar 

  200. Wallace, H. M.; Baumgartner, L. and Rich, H.: Congenital malformations and birth injuries in New York City. Pediatrics 12:525–534, 195

    PubMed  CAS  Google Scholar 

  201. Wallace, H. M.; Hoenig, L. and Rich, H.: Newborn infants with congenital malformations or birth injuries. Amer. J. Dis. Child. 91:529–541, 1956.

    CAS  Google Scholar 

  202. Ward, I. V. and Irvine, E. D.: Incidence of congenital abnormality in infants born in Exeter 1954–1960 inclusive. Med. Offr 106:381–383, 1961.

    Google Scholar 

  203. Ward, I. V. and Irvine, E. D.: Incidence of congenital defects in infants born to Exeter mothers. Med. Offr 108: 195–196, 196

    Google Scholar 

  204. Winter, G. F. and Pätz, A: [Malformation frequency in Berlin and environs in 1950–1956.] Arch. Gynäk. 190:404–418, 1958.

    Article  CAS  Google Scholar 

  205. Wong Hock Boon: Congenital malformations in Singapore. Bull. Kandang Kerbau Hospital Singapore 3:1–12, 1964.

    Google Scholar 

  206. Worm, M.: [Frequency of malformations at Womens Clinic, University of Greifswald from 1930–1950.] Geburtsh. u. Frauenheilk. 12:443–447, 1952.

    CAS  Google Scholar 

  207. Wulf, R.; Gibson, T. C. and Meyer, R. J.: Congenital abnormalities in a Vermont County: detection and medical care. New Engl. J. Med. 274:861–868, 1966.

    Article  PubMed  CAS  Google Scholar 

  208. Yassin, S. M. and Al-Taei, M. S.: Congenital malformations in Mosul, Iraq. Ein. Shams Med. J. (Cairo) 1:1964.

    Google Scholar 

  209. Yerushalmy, J.; Van Den Berg, B. J. and Erhard, T.: Birth weight and gestation as indices of “immaturity.” Neonatal maturity and congenital anomalies of the “immature.” Amer. J. Dis. Child. 109:43–57, 1965.

    PubMed  CAS  Google Scholar 

  210. Zuschlag, H. G.: Inaugural Dissertation. Hamburg 1950, quoted by Sievers.

    Google Scholar 

  211. Zytkiewicz, A.; Bokiniec, M. and Czarkowska, D.: [Statistical analysis of fetal malformations with consideration of certain causes.] Pol. Tyg. lek. 20:1420–1422, 1965.

    PubMed  CAS  Google Scholar 

Addendum

  1. Barret, Bock H. and Zimmerman, J. H.: Study of selected congenital anomalies in Pennsylvania. Publ. Hlth Rep. (Wash.) 82:446–450, 1967.

    Article  Google Scholar 

  2. Lilienfeld, A. M.; Parkhurst, E.; Patton, R. and Schlesinger, E. R.: Accuracy of supplemental medical information on birth certificates. Publ. Hlth Rep. (Wash.) 66:191–198, 1957.

    Article  Google Scholar 

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  1. Department of Obstetrics and Gynaecology, Edinburgh University, UK

    W. P. Kennedy Ph.D., F.R.C.P. (Glas.), F.R.S.E. (Honorary Lecturer)

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  1. W. P. Kennedy Ph.D., F.R.C.P. (Glas.), F.R.S.E.
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  1. Teratology Research Laboratory, University of Manitoba, Canada

    T. V. N. Persaud MD, PhD, DSc, MRCPath, FACOG (Professor of Anatomy and Director, Consultant in Teratology and Pathology) (Professor of Anatomy and Director, Consultant in Teratology and Pathology)

  2. Health Sciences Centre, Winnipeg, Canada

    T. V. N. Persaud MD, PhD, DSc, MRCPath, FACOG (Professor of Anatomy and Director, Consultant in Teratology and Pathology) (Professor of Anatomy and Director, Consultant in Teratology and Pathology)

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Kennedy, W.P. (1967). Epidemiologic Aspects of the Problem of Congenital Malformations. In: Persaud, T.V.N. (eds) Problems of Birth Defects. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6621-8_4

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