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Chromosome Abnormality and Perinatal Death

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Problems of Birth Defects

Summary

A survey of the chromosome constitution of unselected necropsied infants dying in hospital in the perinatal period was carried out in South and East London over a period of two years and nine months. Chromosome results were obtained from 700 of the 726 infants examined. There were 28 infants with chromosome abnormalities, accounting for 9% of macerated stillbirths, 4% of fresh stillbirths, and 6% of early neonatal deaths for which results were obtained. Chromosome abnormalities were found in 13% of infants with lethal malformations and 2–5% of infants dying from other causes. The incidence of El8-trisomy in this survey indicates that this abnormality is more common at birth than is generally accepted. It is suggested that a chromosome analysis should be an integral part of the perinatal necropsy.

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Author information

Author notes

  1. G. A. Machin

    Present address: Department of Pathology, Royal Hospital for Sick Children, Edinburgh, EH9 1LF, UK

Authors and Affiliations

  1. Pædiatric Research Unit, Guy’s Hospital Medical School, London, SE1, UK

    G. A. Machin

Authors
  1. G. A. Machin
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Editor information

Editors and Affiliations

  1. Teratology Research Laboratory, University of Manitoba, Canada

    T. V. N. Persaud MD, PhD, DSc, MRCPath, FACOG (Professor of Anatomy and Director, Consultant in Teratology and Pathology) (Professor of Anatomy and Director, Consultant in Teratology and Pathology)

  2. Health Sciences Centre, Winnipeg, Canada

    T. V. N. Persaud MD, PhD, DSc, MRCPath, FACOG (Professor of Anatomy and Director, Consultant in Teratology and Pathology) (Professor of Anatomy and Director, Consultant in Teratology and Pathology)

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© 1974 The Lancet Ltd

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Machin, G.A. (1974). Chromosome Abnormality and Perinatal Death. In: Persaud, T.V.N. (eds) Problems of Birth Defects. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6621-8_15

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  • DOI: https://doi.org/10.1007/978-94-011-6621-8_15

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-011-6623-2

  • Online ISBN: 978-94-011-6621-8

  • eBook Packages: Springer Book Archive

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