Abstract
Epidemiologic studies, retrospective and prospective, were done on 1500 abortions collected from 1966–1972. No secular or seasonal variations were observed. From the analysis of the relative frequencies of the different types of chromosome anomalies it is estimated that 1 out of every 2 conceptions has a chromosome anomaly. Maternal-age influence was found only for the autosomal trisomy group, mainly D and G trisomies. No effect of oral contraceptives was discovered. An increased frequency of chromosome anomalies occurred after ovulation-inducing therapy and after occupational exposure of the father to irradiation. No variations in the fertility rate and in the frequency of congenital malformations in births following abortions was noted. The incidence of recurring abortion was mainly influenced by the reproductive history of the couple before the karyotyped abortion.
Presented as part of the symposium on methods of testing for teratogenicity and possibilities for the future, at The 14th Annual Meeting of the Teratology Society, July 7–10, 1974, University of British Columbia, Vancouver, B.C., Canada.
Address for reprints: Dr. J. Boué, C.E.B.I.O.P., Château de Longchamp, 75016 Paris, France.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
Literature Cited
Alberman, E. 1973 Epidemiology of spontaneous abortions and their chromosome constitution. In: Chromosomal Errors in Relation to Reproductive Failure. A. Boué and C. Thibault, eds. INSERM, Paris, pp. 305–316.
Alberman, E., P. E. Polani, J. A. F. Roberts, C. C. Spicer, M. Elliot, E. Armstrong, and R. K. Dhadial 1972 Parental X-irradiation and chromosome constitution in their spontaneously aborted foetuses. Ann. Hum. Genet, 36: 185–194.
Arakaki, D. T., and S. H. Waxman 1970 Effect of gestational and maternal age in early abortion. Obst. Gyn., 35: 264–269.
Boué, A., and J. G. Boué 1973a Etudes chromosomiques et anatomiques des grossesses suivant l’arrêt des contraceptifs. J. Gyn. Obst. Biol. Reprod.,2: 141–154.
Boué, A. 1974 Chromosome abnormalities and abortion. In: Physiology and Genetics of Reproduction. Vol. 2. F. M. Coutinho and F. Fuchs, eds. Plenum, New York, pp. 317–339.
Boué, J. G., and A. Boué 1973b Increased frequency of chromosomal anomalies in abortions after induced ovulation. Lancet, 1: 679–680.
Boué, J. G. 1973c Chromosomal analysis of two consecutive abortuses in 43 women. Humangenetik, 19: 275–280.
Boué, A., J. G. Boué, S. Cure, C. Deluchat and N. Perraudin 1975 In vitro cultivation of cells from aneuploid human embryos, initiation of cell lines and longevity of the cultures. In Vitro, in press.
Boué, J. G., A. Boué, and P. Lazar 1967 Les aberrations chromosomiques dans les avortements. Ann. Genet., 10: 179–187.
Boué, J. G. 1974 The epidemiology of human spontaneous abortions with chromosomal anomalies. In: Biology and Pathology of Aging Gametes. R. J. Blandau, ed. Karger, Basel, pp. 330–348.
Boué, J. G., A. Boué, P. Lazar, and S. Gueguen 1973 Outcome of pregnancies following a spontaneous abortion with chromosomal anomalies. Am. J. Obst. Gyn., 116: 806–842.
Carr, D. H. 1967 Chromosome anomalies as a cause of spontaneous abortion. Am. J. Obst. Gyn., 97: 283–293.
Carr, D. H. 1970 Chromosome studies in selected spontaneous abortions. 1. Conception after oral contraceptives. Can. Med. Ass. J., 103: 343–348.
Ford, C. E. 1960 Chromosomal abnormality and congenital malformation. In: CIBA Foundation Symposium on Congenital Malformations. G. E. W. Wolstenholme and C. M. O’Connor, eds. Churchill, London, pp. 32–47.
Fraser, G. R. 1963 Parental origin of the sex chromosomes in the XO and XXY karyotypes in man. Ann. Hum. Genet., 26: 297.
Gropp, A. 1974 Fetal mortality due to aneuploidy and irregular meiotic segregation in the mouse. In: Chromosomal Errors in Relation to Reproductive Failure. A. Boué and C. Thibault, eds. INSERM, Paris, pp. 255–269.
Hertig, A. T., and J. Rock 1973 Searching for early fertilized human ova. Gyn. Inv., 4: 121–139.
James, W. H. 1963 Note towards an epidemiology of spontaneous abortion. Am. J. Hum. Genet., 15: 223–240.
Kajii, T., K. Ohama, N. Nükawa, A. Ferrier, and S. Avirachan 1973 Banding analysis of chromosomal karyotypes in spontaneous abortion. Am. J. Hum. Genet., 25: 539–547.
Klinger, H. P., H. W. Kava, M. Glasser, and A. Kallenberg 1973 Cytogenetic, anthropometric and developmental studies of postcontraceptive reproduction in man. An interim report In: Chromosomal Errors in Relation to Reproductive Failure. A. Boué and C. Thibault, eds. INSERM, Paris, pp. 371–389.
Lilienfeld, A. M. 1969 Epidemiology of Mongolism. Johns Hopkins Press, Baltimore.
Pearson, P. L., J. P. M. Geraldts, and I. H. Pawlowitzki 1974 Chromosomal studies on human male gametes. In: Chromosomal Errors in Relation to Reproductive Failure. A. Boué and C. Thibault, eds. INSERM, Paris, pp. 219–229.
Penrose, L. S., and G. F. Smith 1966 Down’s Anomaly. Churchill, London.
Russel, S. C, R. Taylor, and R. N. Madison 1966 Some effects of smoking on pregnancy. J. Obst. Gyn. Br. Comm., 73
Schwartz, D., J. Goujard, M. Kaminski, and C. Rumeau = Rouquette 1972 Smoking and pregnancy. Results of a prospective study of 6989 women. Rev. Eur. Etud., 17: 867-874.
Stenchever, M. A., J. M. Hempel, and M. N. Macintyre 1967 Cytogenetics of spontaneously aborted human fetuses. Obst. Gyn., 30: 683–691.
Szulman, A. E. 1965 Chromosomal aberrations in spontaneous human abortions. New Eng. J. Med., 272. 811–818.
Therkelsen, A. J., N. Grunnet, T. Hjort, O. Myhre Jensen, J. Jonasson, J. G. Lauritsen, J. Lindsten, and B. Petersen 1974 Studies on spontaneous abortions. In: Chromosomal Errors in Relation to Reproductive Failure. A. Boué and C. Thibault, eds. INSERM, Paris, pp. 81–93.
Warburton, D., and F. C. Fraser 1964 Spontaneous abortion risks in man: data from reproduction histories collected in a medical genetic unit. Am. J. Hum. Genet., 16: 1–25.
Witschi, E. 1970 Teratogenetic effects from overripeness of the egg. In: Congenital Malformations. Excerpta Med. Int. Cong. Ser. No. 204, Amsterdam, pp. 157-169.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1975 Wistar Institute Press
About this chapter
Cite this chapter
Boué, J., Boué, A., Lazar, P. (1975). Retrospective and Prospective Epidemiological Studies of 1500 Karyotyped Spontaneous Human Abortions. In: Persaud, T.V.N. (eds) Problems of Birth Defects. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6621-8_14
Download citation
DOI: https://doi.org/10.1007/978-94-011-6621-8_14
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-011-6623-2
Online ISBN: 978-94-011-6621-8
eBook Packages: Springer Book Archive