Abstract
Epidemiological studies have consistently demonstrated that the plasma high density lipoproteins (HDL) are inversely correlated with the risk of coronary artery disease (CAD)1,2. HDL are highly heterogeneous with respect to the hydrated density, size and composition of the particles. The major apolipoprotein (apo) in HDL, apoA-I, has been shown to have a strong inverse correlation with risk of CAD3–5, whereas an inverse correlation with apoA-II levels has not been consistently demonstrated3. It has been shown by several laboratories that there are several subclasses of apoA-I containing particles. The two major subclasses include particles that contain both apoA-I and apoA-II (termed LpA-I, A-II) and those that contain apoA-I but not apoA-II (termed LpA-I). Apo-specific particles can be isolated by use of immunoaffinity columns with anti-apoA-I or anti-apoA-II antibody6,7.
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© 1995 Kluwer Academic Publishers
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Fruchart, J.C., De Geteire, C., Delfy, B., Castro, G.R. (1995). Connection between cholesterol efflux and atherosclerosis. In: Assmann, G. (eds) HDL Deficiency and Atherosclerosis. Developments in Cardiovascular Medicine, vol 174. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6585-3_3
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DOI: https://doi.org/10.1007/978-94-011-6585-3_3
Publisher Name: Springer, Dordrecht
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