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Perinatal Effects of Metals and Cancer in Offspring

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Cytotoxic, Mutagenic and Carcinogenic Potential of Heavy Metals Related to Human Environment

Part of the book series: NATO ASI Series ((ASEN2,volume 26))

Abstract

Human exposure to metals, environmentally or occupationally, continues to increase in many areas [1]. Such exposures of both men and women may adversely affect their reproductive capability, and impact on fertility and on pregnancy outcomes. Recent reviews are available, covering studies of effects on fertility, spontaneous abortions, premature delivery, low birth weight, and teratogenesis in humans [2, 3], and developmental toxicity in laboratory animals [4]. An even more insidious concern is the possibility of causation of persistent subtle deleterious effects in the offspring, as a result of preconception, transplacental, or neonatal exposure. Neurological effects have been documented, especially for transplacental and neonatal exposure to lead [5] and methylmercury [6]. In addition, over the last several years, evidence has been accumulating from both epidemiological and experimental investigations that perinatal exposure to metals may result in a later increase in risk for cancer. This evidence is reviewed here.

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Authors and Affiliations

  1. Laboratory of Comparative Carcinogenesis, Division of Basic Sciences, National Cancer Institute, USA

    M. A. Sipowicz, B. A. Diwan, D. Ramljak, G. S. Buzard, W. Yu, M. P. Waalkes, J. M. Rice, K. S. Kasprzak & L. M. Anderson

  2. Intramural Research Support Program, SAIC Frederick, Frederick Cancer Research and Development Center, Frederick, MD, USA

    B. A. Diwan

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  1. M. A. Sipowicz
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  2. B. A. Diwan
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  3. D. Ramljak
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  4. G. S. Buzard
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  6. M. P. Waalkes
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  8. K. S. Kasprzak
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  9. L. M. Anderson
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  1. Laboratory of Inorganic and General Chemistry, Department of Chemistry, University of Ioannina, Ioannina, Greece

    Nick D. Hadjiliadis

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Sipowicz, M.A. et al. (1997). Perinatal Effects of Metals and Cancer in Offspring. In: Hadjiliadis, N.D. (eds) Cytotoxic, Mutagenic and Carcinogenic Potential of Heavy Metals Related to Human Environment. NATO ASI Series, vol 26. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5780-3_8

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