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Modeling the Metal Binding Sites in Core Histones: Interactions of Carcinogenic Ni(II) with the -CAIH- Motif of Histone H3

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Cytotoxic, Mutagenic and Carcinogenic Potential of Heavy Metals Related to Human Environment

Part of the book series: NATO ASI Series ((ASEN2,volume 26))

Abstract

This paper presents results of studies on interactions of carcinogenic nickel with -CAIH-, a potential metal binding motif in nuclear chromatin. Structural and mechanistic results are discussed in the perspective of various concepts in nickel carcinogenesis. Evidence is presented for a major role of oxidative mechanism of damage caused by Ni(II) binding and reactivity on both genotoxic (DNA) and epigenetic (core histones) levels. Preliminary results of a study of (H3-H4)2 histone tetramer supporting the validity of CAIH model are also shown.

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Authors and Affiliations

  1. Laboratory of Comparative Carcinogenesis, National Cancer Institute, FCRDC, Building 538, Room 205, Frederick, Maryland, 21702-1201, USA

    W. Bal & K. S. Kasprzak

  2. Faculty of Chemistry, University of Wroclaw, Wroclaw, Poland

    W. Bal

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  1. W. Bal
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  2. K. S. Kasprzak
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  1. Laboratory of Inorganic and General Chemistry, Department of Chemistry, University of Ioannina, Ioannina, Greece

    Nick D. Hadjiliadis

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Bal, W., Kasprzak, K.S. (1997). Modeling the Metal Binding Sites in Core Histones: Interactions of Carcinogenic Ni(II) with the -CAIH- Motif of Histone H3. In: Hadjiliadis, N.D. (eds) Cytotoxic, Mutagenic and Carcinogenic Potential of Heavy Metals Related to Human Environment. NATO ASI Series, vol 26. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5780-3_7

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  • DOI: https://doi.org/10.1007/978-94-011-5780-3_7

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